Neuroprotective agents : sixth international conference / edited by William Slikker, Jr., Russell J. Andrews, and Bruce Trembly.

Format:

Book

Conference/Event

Contributor:

Slikker, William, Jr.

Andrews, Russell J.

Trembly, Bruce.

Conference Name:

International Conference on Neuroprotective Agents: Clinical and Experimental Aspects (6th : 2002 : Hilton Head, S.C.)

Series:

Annals of the New York Academy of Sciences ; v. 993.

Annals of the New York Academy of Sciences ; v. 993

Language:

English

Subjects (All):

Nervous system--Degeneration--Chemoprevention--Congresses.

Nervous system.

Neuropharmacology--Congresses.

Neuropharmacology.

Neurotoxicology--Congresses.

Neurotoxicology.

Nerve Degeneration--prevention & control.

Nervous system--Degeneration--Chemoprevention.

Nervous system--Degeneration.

Neuroprotective Agents--therapeutic use.

Neurotoxicity Syndromes--therapy.

Medical Subjects:

Nerve Degeneration--prevention & control.

Neuroprotective Agents--therapeutic use.

Neurotoxicity Syndromes--therapy.

Genre:

Conference papers and proceedings.

Physical Description:

396 pages : illustrations ; 24 cm.

Place of Publication:

New York : New York Academy of Sciences, 2003.

Contents:

Session I Clinical Trials and Beyond

Neuroprotection Trek

The Next Generation: Neuromodulation I. Techniques

Deep Brain Stimulation, Vagus Nerve Stimulation, and Transcranial Magnetic Stimulation / Russell J. Andrews 1

The Next Generation: Neuromodulation II. Applications

Epilepsy, Nerve Regeneration, Neurotrophins / Russell J. Andrews 14

Evaluation of Topiramate Neuroprotective Effect in Severe TBI Using Microdialysis / Oscar L. Alves, Aiden J. Doyle, Tobias Clausen, Charlotte Gilman, Ross Bullock 25

Melatonin Ameliorates Neurologic Damage and Neurophysiologic Deficits in Experimental Models of Stroke / Russel J. Reiter, Rosa M. Sainz, Silvia Lopez-Burillo, Juan C. Mayo, Lucien C. Manchester, Dun Xian Tan 35

Session II Clinical Application of Neuroprotective Approaches

Gene Therapy and Hypothermia for Stroke Treatment / Midori A. Yenari, Heng Zhao, Rona G. Giffard, Raymond A. Sobel, Robert M. Sapolsky, Gary K. Steinberg 54

Why Have So Many Drugs with Stellar Results in Laboratory Stroke Models Failed in Clinical Trials? A Theory Based on Allometric Relationships / Stephen H. Curry 69

EEG Deficits in Chronic Marijuana Abusers during Monitored Abstinence: Preliminary Findings / Ronald I. Herning, Warren Better, Kimberly Tate, Jean L. Cadet 75

Session III NMDA Receptors as Mediators of Neurotoxicity/Protection

The Molecular Effects of Alcohol: Clues to the Enigmatic Action of Alcohol / Meena Kumari, Antje Anji, Henri Woods, Jr., Maharaj K. Ticku 82

Effect of Ethanol on Lipid-Mediated Transfection of Primary Cortical Neurons / Antje Anji, Kamran A. Shaik, Meena Kumari 95

Antiepileptic Drugs and Apoptosis in the Developing Brain / Petra Bittigau, Marco Sifringer, Chrysanthy Ikonomidou 103

Neurotoxicity of Nitrous Oxide and Ketamine Is More Severe in Aged than in Young Rat Brain / J.K. Beals, L.B. Carter, V. Jevtovic-Todorovic 115

Chronic Exposure to NMDA Receptor and Sodium Channel Blockers during Development in Monkeys and Rats: Long-Term Effects on Cognitive Function / Merle G. Paule, C. Matthew Fogle, Richard R. Allen, Edwin C. Pearson, Timothy G. Hammond, E. Jon Popke 116

Session IV Models of Neurotoxicity and Neuroprotection

Estrogen as a Neuroprotective Agent in the Treatment of Spinal Cord Injury / Eric Anthony Sribnick, James Michael Wingrave, Deborah Denise Matzelle, Swapan Kumar Ray, Naren Lal Banik 125

N-Methyl-d-aspartate and TrkB Receptor Activation in Cerebellar Granule Cells: An In Vitro Model of Preconditioning to Stimulate Intrinsic Survival Pathways in Neurons / Xueying Jiang, Daming Zhu, Peter Okagaki, Robert Lipsky, Xuan Wu, Krishna Banaudha, Karen Mearow, Kenneth I. Strauss, Ann M. Marini 134

Prediction of Experimental Data for an Independent Variable Using the Experimental Data Collected for Other Independent Variables in a Study of Skin Cancer Caused by Exposure to UV Radiation / Ray R. Hashemi, Mahmood Bahar, Nan Tang, Alexander A. Tyler, William Hinson 146

Neuroprotection or Neurotoxicity: Impact of Discontinuous Dose-Response Curves on Risk Assessment / William Slikker, Jr., Helen Duhart, David Gaylor, Syed Imam 158

Session V Modulators of Neurotoxicity and Neuroprotection

Mating Attenuates Aging-Associated Increase of Lipid Peroxidation Activity in C57BL/6J Mice / Gregory F. Oxenkrug, Pura J. Requintina 161

Hypoxic Preconditioning Prevents Cortical Infarction by Transient Focal Ischemia-Reperfusion / Anya M.Y. Lin, Shiang-Wen Dung, Chau-Fong Chen, Wen-Han Chen, Low-Tone Ho 168

Environmental Conditions Unexpectedly Affect the Long-Term Extent of Cell Death Following an Hypoxic Episode / Robert L. Isaacson, Jeanne M. Fahey, Fadwa Al Mughairbi 179

Session VI Mechanisms of Neuroprotection

Possible Mechanism for the Neuroprotective Effects of l-Carnitine on Methamphetamine-Evoked Neurotoxicity / Ashraf Virmani, Franco Gaetani, Syed Imam, Zbigniew Binienda, Syed Ali 197

Prostaglandins of J Series Control Heme Oxygenase Expression: Potential Significance in Modulating Neuroinflammation / Hean Zhuang, Yun-Sook Kim, Khodadad Namiranian, Sylvain Dore 208

Poly(ADP-Ribose) Polymerase-1 in Acute Neuronal Death and Inflammation: A Strategy for Neuroprotection / Stephen D. Skaper 217

Multiple Sclerosis and Glutamate / Anthony J. Groom, Terence Smith, Lechoslaw Turski 229

Potential Mechanism by Which Resveratrol, a Red Wine Constituent, Protects Neurons / Hean Zhuang, Yun-Sook Kim, Raymond C. Koehler, Sylvain Dore 276

Session VII Oxidative Stress, Mitochondria, and Approaches to Neuroprotection

Neuroprotective Effects of l-Carnitine in Induced Mitochondrial Dysfunction / Zbigniew K. Binienda 289

The Acute Effects of Acrylamide on Astrocyte Functions / Michael Aschner, Cheng-Chen Cao, Qi Wu, Marvin A. Friedman 296

3-Nitropropionic Acid Inhibition of Succinate Dehydrogenase (Complex II) Activity in Cultured Chinese Hamster Ovary Cells: Antagonism by l-Carnitine / Andrew C. Scallet, Raney L. Haley, Dori M. Scallet, Helen M. Duhart, Zbigniew K. Binienda 305

Systemic Vitamin D3 Attenuated Oxidative Injuries in the Locus Coeruleus of Rat Brain / Kuen-Bor Chen, Anya Maan-Yuh Lin, Tsai-Hsien Chiu 313

Differential Effects of Lipopolysaccharide on Lipid Peroxidation in F344N, SHR Rats and BALB/c Mice, and Protection of Melatonin and NAS against Its Toxicity / Pura J. Requintina, Gregory F. Oxenkrug 325

Mitochondria as a Target for Neurotoxins and Neuroprotective Agents / Sergey O. Bachurin, Elena P. Shevtsova, Elena G. Kireeva, Gregory F. Oxenkrug, Sergey O. Sablin 334

Session VIII Genomic Approaches to Understanding Neurotoxicity and Neuroprotection

The Role of Caspase III Inhibition in Methamphetamine-Induced Alterations in p53 and bcl-2 Expression: Correlation with Dopaminergic Neurotoxicity / Syed Z. Imam, Michelle Oetinger, John T. Skinner, W. Slikker, Jr., Syed F. Ali 350

Gene and Protein Expression Profiles of Anti- and Pro-apoptotic Actions of Dopamine, R-Apomorphine, Green Tea Polyphenol (-)-Epigallocatechine-3-gallate, and Melatonin / Orly Weinreb, Silvia Mandel, Moussa B.H. Youdim 351

Cocaine Induces a Dose-Dependent Alteration in the Expression of Immediate Early Genes c-fos and SP-1 and in Nuclear Factor NF-[kappa beta] in PC12 Cells / Syed Z. Imam, Helen M. Duhart, John T. Skinner, Syed F. Ali 362

A Statistical Approach in Using cDNA Array Analysis to Determine Modest Changes in Gene Expression in Several Brain Regions after Neurotoxic Insult / Robert R. Delongchamp, Angela J. Harris, John F. Bowyer 363

Molecular Mechanisms of Dopaminergic Neurodegeneration: Genetic and Environmental Basis / Syed Z. Imam 377

Amyloid Processing and Signal Transduction Properties of Antiparkinson-Antialzheimer Neuroprotective Drugs Rasagiline and TV3326 / Moussa B.H. Youdim, Tamar Amit, Orit Bar-Am, Marta Weinstock, Merav Yogev-Falach 378.

Notes:

Includes bibliographical references and index.

ISBN:

1573314684

1573314692

OCLC:

52039221