Parkinson's disease : the life cycle of the dopamine neuron / edited by Howard J. Federoff ... [and others].

Format:

Book

Contributor:

Federoff, Howard.

Series:

Annals of the New York Academy of Sciences ; v. 991.

Annals of the New York Academy of Sciences ; v. 991

Language:

English

Subjects (All):

Parkinson's disease--Pathophysiology--Congresses.

Parkinson's disease.

Parkinson's disease--Molecular aspects--Congresses.

Dopaminergic neurons--Congresses.

Dopaminergic neurons.

Dopaminergic mechanisms--Congresses.

Dopaminergic mechanisms.

Parkinson Disease.

Parkinson's disease--Pathophysiology.

Dopamine--biosynthesis.

Medical Subjects:

Parkinson Disease.

Dopamine--biosynthesis.

Genre:

Conference papers and proceedings.

Physical Description:

360 pages : illustrations ; 24 cm.

Place of Publication:

New York : The New York Academy of Sciences, 2003.

Contents:

Part I. Clinical Syndrome

Description of Parkinson's Disease as a Clinical Syndrome / Stanley Fahn 1

Physiology and Pathophysiology of Parkinson's Disease / Clement Hamani, Andres M. Lozano 15

PET Studies on the Function of Dopamine in Health and Parkinson's Disease / David J. Brooks 22

Part II. Development

Midbrain Dopaminergic Neurons: Determination of Their Developmental Fate by Transcription Factors / Horst H. Simon, Lavinia Bhatt, Daniel Gherbassi, Paola Sgado, Lavinia Alberi 36

Transcriptional Control of Dopamine Neuron Development / Asa Wallen, Thomas Perlmann 48

Transcription Factors in the Development of Midbrain Dopamine Neurons / J. Peter, H. Burbach, Simone Smits, Marten P. Smidt 61

Postnatal Developmental Programmed Cell Death in Dopamine Neurons / Robert E. Burke 69

Part III. From Molecules to Organism: The Molecules

The Cast of Molecular Characters in Parkinson's Disease: Felons, Conspirators, and Suspects / Kah Leong Lim, Valina L. Dawson, Ted M. Dawson 80

Oxidative Modifications of [alpha]-Synuclein / Harry Ischiropoulos 93

Parkin and Endoplasmic Reticulum Stress / Ryosuke Takahashi, Yuzuru Imai, Nobutaka Hattori, Yoshikuni Mizuno 101

Parkinson's Disease and Related [alpha]-Synucleinopathies Are Brain Amyloidoses / John Q. Trojanowski, Virginia M-Y. Lee 107

Part IV. From Molecules to Organism: The Cells

Mitochondrial Mechanisms of Neural Cell Death and Neuroprotective Interventions in Parkinson's Disease / Gary Fiskum, Anatoly Starkov, Brian M. Polster, Christos Chinopoulos 111

Mitochondria, Oxidative Damage, and Inflammation in Parkinson's Disease / M. Flint Beal 120

Apoptosis Inducing Factor and PARP-Mediated Injury in the MPTP Mouse Model of Parkinson's Disease / Hongmin Wang, Mika Shimoji, Seong-Woon Yu, Ted M. Dawson, Valina L. Dawson 132

Cellular Models to Study Dopaminergic Injury Responses / Timothy J. Collier, Kathy Steece-Collier, Susan McGuire, Caryl E. Sortwell 140

Convergent Pathobiologic Model of Parkinson's Disease / Kathleen A. Maguire-Zeiss, Howard J. Federoff 152

The Relationship between Lewy Body Disease, Parkinson's Disease, and Alzheimer's Disease / John Hardy 167

Part V. From Molecules to Organism: The Organism

Transgenic Models of [alpha]-Synuclein Pathology: Past, Present, and Future / Makoto Hashimoto, Edward Rockenstein, Eliezer Masliah 171

The 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model: A Tool to Explore the Pathogenesis of Parkinson's Disease / Serge Przedborski, Miquel Vila 189

Pathophysiology of Parkinson's Disease: The MPTP Primate Model of the Human Disorder / Thomas Wichmann, Mahlon R. DeLong 199

The Role of Glial Reaction and Inflammation in Parkinson's Disease / E. C. Hirsch, T. Breidert, E. Rousselet, S. Hunot, A. Hartmann, P. P. Michel 214

Part VI. Convergence of Cell Genesis and Cell Transfer

Induction of Adult Neurogenesis: Molecular Manipulation of Neural Precursors in Situ / Paola Arlotta, Sanjay S. Magavi, Jeffrey D. Macklis 229

Molecular Mechanisms of Neuronal Cell Death / Kim A. Heidenreich 237

Redox State as a Central Modulator of Precursor Cell Function / Mark Noble, Joel Smith, Jennifer Power, Margot Mayer-Proschel 251

COX-2 and Neurodegeneration in Parkinson's Disease / P. Teismann, M. Vila, D.-K. Choi, K. Tieu, D. C. Wu, V. Jackson-Lewis, S. Przedborski 272

Striatopallidal Changes in a Preclinical Rat Model of Parkinson's Disease / A. E. Grissell, T. M. Buchanan, M. A. Ariano 278

Neurotoxicity-Induced Changes in Striatal Dopamine Receptor Function / Anna-Liisa Brownell, Iris Y. Chen, Xukui Wang, Meixiang Yu, Bruce G. Jenkins 281

The Developmental Time Course of Glial Cell Line-Derived Neurotrophic Factor (GDNF) and GDNF Receptor [alpha]-1 mRNA Expression in the Striatum and Substantia Nigra / JinWhan Cho, Nikolai G. Kholodilov, Robert E. Burke 284

Subcellular Compartmentalization of P-ERKs in the Lewy Body Disease Substantia Nigra / Charleen T. Chu, Jian-Hui Zhu 288

Altered Striatal Neuronal Morphology Is Associated with Astrogliosis in a Chronic Mouse Model of Parkinson's Disease / A. G. Dervan, S. Totterdell, Y.-S. Lau, G. E. Meredith 291

Is the Initial Insult in Parkinson's Disease and Dementia with Lewy Bodies a Neuritic Dystrophy? / John E. Duda, Benoit I. Giasson, Virginia M-Y. Lee, John Q. Trojanowski 295

Neuroplasticity in the MPTP-Lesioned Mouse and Nonhuman Primate / Michael W. Jakowec, Beth Fisher, Kerry Nixon, Elizabeth Hogg, Charles Meshul, Samuel Bremmer, Tom McNeill, Giselle M. Petzinger 298

An Experimental Infection by Filterable Forms of Nocardia asteroides and Late-Onset Movement Disorder in Mice / S. Kohbata, C. Kadoya 302

A Characterization of Dopaminergic Neurodegeneration in Organotypic Cultures / Geraldine J. Kress, Ian J. Reynolds 304

Developmental Cell Death and Oxidative Stress: Lessons from Nigral Dopamine Neurons / Laurent Groc, Tangella Jackson Hunter, Hao Jiang, Laurent Bezin, Robert A. Levine 307

Identification of a Novel Gene Linked to Parkin via a Bidirectional Promoter / Paul J. Lockhart, Andrew B. West, Casey A. O'Farrell, Matthew J. Farrer 311

Gene Expression Analysis of the MPTP-Lesioned Substantia Nigra in Mice / R. M. Miller, C. Casaceli, L. Chen, H. J. Federoff 315

Neuroimaging and Proteomic Tracking of Neurodegeneration in MPTP-Treated Mice / Howard E. Gendelman, Christopher J. Destache, Marina L. Zelivyanskaya, Jay A. Nelson, Michael D. Boska, Toni M. Biskup, Michael K. McCarthy, Kimberly A. Carlson, Craig Nemechek, Eric J. Benner, R. Lee Mosley 319

PCBs and Dopamine Function: Neurological Effects of Polychlorinated Biphenyls: Does Occupational Exposure Alter Dopamine-Mediated Function? / Richard F. Seegal 322

A Murine Model of ALS-PDC with Behavioral and Neuropathological Features of Parkinsonism / J. D. Schulz, J. M. B. Wilson, C. A. Shaw 326

Neuroprotective Ganglioside Derivatives / K. Conn, S. Doherty, P. Eisenhauer, R. Fine, J. Wells, M. D. Ullman 330

Redox- and Metalloregulated RNA Bioaptamer Targets of Proteins Associated with Parkinson's and Other Neurodegenerative Diseases: Factors of Relevance in the Life Cycle of Cells / Josef H. Wissler 333

Dopaminergic Stimulatory Polypeptides from Immortalized Striatal Cells / Alfred Heller, Martin Gross, Suzanne Hessefort, Nancy Bubula, Lisa Won 339

Glutathione and Ascorbate: Their Role in Protein Glutathione Mixed Disulfide Formation during Oxidative Stress and Potential Relevance to Parkinson's Disease / Gail D. Zeevalk, Laura P. Bernard, Julie Ehrhart 342

Dopaminergic Neurons in Human Striatum and Neurogenesis in Adult Monkey Striatum / Martine Cossette, Andreanne Bedard, Andre Parent 346

Secreted Factors from Primary Midbrain Glia Regulate Nurr 1 Activity / Y. Luo, H. J. Federoff 350

Development of Nurr 1 Stable Cell Lines for the Identification of Downstream Targets / Yu Luo, Leigh A. Henricksen, Kathleen A. Maguire-Zeiss, Howard J. Federoff 354.

Notes:

"This volume is the result of a conference entitled Parkinson's disease: the life cycle of the dopamine neuron, sponsored by the New York Academy of Sciences held on September 18-20, 2002 in Princeton, New Jersey"--Contents p.

Includes bibliographical references and index.

ISBN:

157331448X

1573314498

OCLC:

52128265