Dendritic cells and virus infection / A. Steinkasserer (ed.)

Format:

Book

Contributor:

Steinkasserer, A. (Alexander)

Series:

Current topics in microbiology and immunology 0070-217X ; 276.

Current topics in microbiology and immunology, 0070-217X ; 276

Language:

English

Subjects (All):

Dendrites.

Viruses.

Dendritic Cells--virology.

Dendritic Cells--immunology.

Immunity, Cellular.

Immunotherapy.

Medical Subjects:

Dendritic Cells--virology.

Dendritic Cells--immunology.

Immunity, Cellular.

Immunotherapy.

Physical Description:

x, 296 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Berlin ; New York : Springer, [2003]

Summary:

Dendritic cells (DC) are vital to induce potent anti-viral immune responses. However, viruses have developed a large number of different escape mechanisms in order to overcome the host immune system. A prime target in this respect are DC, since they are the only antigen presenting cell able to induce also naive T cells. In the present CTMI-volume the interaction between several viruses, including HIV-1, SIV, EBV, measles virus, LCMV and HSV-1, with DC will be described and discussed. It will become clear to the reader that DC often play a dual role during viral infections. On the one hand they are able to mount potent antiviral immune responses, and the other hand several viruses, including HIV-1, use DC as a vector to be transferred from the periphery to the lymph nodes where they infect their prime target cells. In the second part of this volume several DC specific immune intervention strategies will be presented. This includes topics such as DC vaccination strategies in immunotherapy, viral vectors for the genetic modification of DC and cross presentation of virus-infected cells by DC.

Contents:

Part 1 Interaction of Dendritic Cells and Viruses

The Interaction of Immunodeficiency Viruses with Dendritic Cells / R. Steinman, A. Granelli-Piperno, M. Pope, C. Trumpfheller, R. Ignatius, G. Arrode, P. Racz, K. Tenner-Racz 1

DC-SIGN: A Novel HIV Receptor on DC that Mediates HIV-1 Transmission / T.B.H. Geijtenbeek, Y. van Kooyk 31

Contrasting Roles of Dendritic Cells and B Cells in the Immune Control of Epstein-Barr Virus / K. Bickham, C. Munz 55

Dendritic Cells and Measles Virus Infection / S. Schneider-Schaulies, I.M. Klagge, V. ter Meulen 77

Measles Virus and Dendritic Cell Functions: How Specific Response Cohabites with Immunosuppression? / C. Servet-Delprat, P.-O. Vidalain, H. Valentin, C. Rabourdin-Combe 103

Infection of Dendritic Cells by Lymphocytic Choriomeningitis Virus (LCMV) / N. Sevilla, S. Kunz, D. McGavern, M.B.A. Oldstone 125

The Interaction between Dendritic Cells and Herpes Simplex Virus-1 / D. Kobelt, M. Lechmann, A. Steinkasserer 145

Part 2 Dendritic Cells and Immune-Intervention Strategies

Dendritic Cell-Based Immunotherapy / T.G. Berger, E.S. Schultz 163

Dendritic Cell Vaccination and Viral Infection

Animal Models / B. Ludewig 199

Interplay Between Human Papilloma Viruses and Dendritic Cells / R. Offringa, A. de Jong, R.E.M. Toes, S.H. van der Burg, C.J.M. Melief 215

Viral Vectors for Dendritic Cell-Based Immunotherapy / J. Humrich, L. Jenne 241

Cross Presentation of Cell-Associated Antigens by Dendritic Cells / M. Larsson, J.F. Fonteneau, N. Bhardwaj 261

Dendritic Cells and HCMV Cross Presentation / G. Arrode, C. Davrinche 277.

Notes:

Includes bibliographical references and index.

ISBN:

3540442901

OCLC:

51481662