Inosine monophosphate dehydrogenase : a major therapeutic target / Krzysztof W. Pankiewicz, editor, Barry M. Goldstein, editor.

Format:

Book

Contributor:

Pankiewicz, Krzysztof W., 1942-

Goldstein, Barry M., 1952-

Series:

ACS symposium series ; 839.

ACS symposium series ; 839

Language:

English

Subjects (All):

IMP dehydrogenase--Congresses.

IMP dehydrogenase.

IMP dehydrogenase--Inhibitors--Congresses.

Genre:

Conference papers and proceedings.

Physical Description:

xiv, 352 pages, 8 unnumbered pages of plates : illustrations (some color) ; 24 cm.

Place of Publication:

Washington, DC : American Chemical Society ; [Cary, N.C.] : Distributed by Oxford University Press, [2003]

Summary:

Inosine Monophosphate Dehydrogenase: A Major Therpeutic Target provides a comphrensive look at the chemotherapeutic inosine monophosphate deydrogenase. In addition to an overview of the field, this volume examines the molecular biology and gentics, the structure and mechanisms of IMPDH, inhibitor design, clinical applications, and new trends for the future. Human IMPDH exists as two isoforms, type I and type II. Type I is expresses constitutively in normal cells, while type II is expressed predominantly in cancer cells and activated lymphocytes. Thus, the type II is a major target for the development of anticancer and immunosuppressive drugs. Inosine Monophosphate Dehydrogenase: A Major Therapeutic Target provides a comprehensive look at the chemotherapeutic target inosine monophosphate dehydrogenase. This volume includes sections on molecular biology and genetics, structure and mechanism, and inhibitor design and clinical applications.

Notes:

"... no atetmpts had been made to integrate results from the medicinal chemists, biochemists, biologists, clinicians, and members of the pharmaceutical industry interested in the role of this enzyme as a drug target. To fill this gap, we organized the first national symposium on this topic, titled Inosine Monophosphate Dehydrogenase (IMPDH): Perspectives on a Major Therapeutic Target, held August 20-21 , 2000 at the American Chemical Society (ACS) Annual Meeting in Washington D.C."--Preface.

Includes bibliographical references and indexes.

ISBN:

0841237808

OCLC:

50773579