The role of aging in atherosclerosis : the sequestration hypothesis / by Richard E. Tracy.

Format:

Book

Author/Creator:

Tracy, Richard E., 1934-

Language:

English

Subjects (All):

Atherosclerosis--Etiology.

Atherosclerosis.

Blood-vessels--Aging.

Blood-vessels.

Atherosclerosis--Age factors.

Arteriosclerosis--etiology.

Arteriosclerosis.

Aged.

Blood Vessels--pathology.

Aging.

Medical Subjects:

Arteriosclerosis--etiology.

Arteriosclerosis.

Aged.

Blood Vessels--pathology.

Physical Description:

x, 273 pages : illustrations ; 25 cm

Place of Publication:

Dordrecht ; Boston : Kluwer Academic Publishers, [2003]

Summary:

Age is the dominant risk factor for atherosclerosis and its complications including heart attack, congestive heart failure, and stroke. Yet little is known about the way that aging acts to prepare arteries for atheroma. This book is the first in many decades to address aging as a risk factor, and claims a broad range of success, giving previously unsuspected explanations. Most of the material here is outside of the usual range pursued in this active field during recent decades, and serves to open new avenues of inquiry into neglected topics. The mathematical treatment of the subject matter is daunting but rarely goes beyond the level of high school algebra. Furthermore, it is not necessary to master the mathematics in order to grasp the biological principles. This book provides observations and insights that originate with this author, and much of this is new material not previously published. The target audience is exclusively research scientists. The topics addressed are chiefly the biology of aging, atherosclerosis, hypertension, and diabetes, including the microvascular features of these disorders. Anyone studying these topics will find the book compelling.

Contents:

Chapter 2 The sampling theory of fibrotic arteriosclerosis 11

Chapter 3 Intrusion of atheroma into the most fibrotically thickened intimal sites 19

Chapter 4 Conditions for the intrusion of atheroma in coronary artery 29

Chapter 5 The size of the SMC realm assessed with the help of sampling theory 37

Chapter 6 Biased censoring of low SMC sites by atheroma in coronary artery 51

Chapter 7 Biased sampling of low SMC sites by atheroma in thoracic aorta 67

Chapter 8 SMC numbers at varying depths in intima of thoracic aorta 81

Chapter 9 Histologic appearances of SMC clusters and realms 97

Chapter 10 Direct imaging of the hypothetical quantity, sequestered lipid 103

Chapter 11 Local sequestration of lipid from place to place within an artery 119

Chapter 12 Fibroplasia in microscopic renal arteries 131

Chapter 13 Parameters of fibroplasia in renal microvasculature 141

Chapter 14 The course of arterial intimal fibroplasia in aging arteries 149

Chapter 15 The course of fibroplasia per SMC over time in aging arteries 159

Chapter 16 Fibroplasia per SMC in the media of coronary arteries 165

Chapter 17 Influence of arteriolar hyalinization on renovascular fibroplasia 183

Chapter 18 The Hy effect on R[subscript a] in widely variable circumstances 197

Chapter 19 Hyalinized renal arterioles and the maleness coronary risk factor 211

Chapter 20 Two pathways to atheroma variably linked to renovasculopathies 223

Chapter 21 Age of onset of the sex difference in coronary fibroplasia 233

Chapter 22 Adrenocortical nodularity in relation to coronary fibroplasia 237

Chapter 23 Atheroma and intimal fibroplasia in periodontal disease 247

Chapter 24 Atheroma and intimal fibroplasia in relation to obesity 255

Chapter 25 Paucity of literature relevant to SMC numbers and the aging risk factor 265.

Notes:

Includes bibliographical references (pages [269]-273).

ISBN:

1402012233

OCLC:

51779834