Fluorescence diagnosis and photodynamic therapy of skin diseases : atlas and handbook / Clemens Fritsch, Thomas Ruzicka.

Format:

Book

Author/Creator:

Fritsch, Clemens.

Contributor:

Růžička, T.

Language:

English

Subjects (All):

Skin--Diseases--Photochemotherapy.

Skin.

Skin--Diseases--Diagnosis.

Phototherapy.

Skin Diseases--therapy.

Photochemotherapy.

Skin--Diseases.

Medical Subjects:

Phototherapy.

Skin Diseases--therapy.

Photochemotherapy.

Physical Description:

vi, 124 pages : illustrations (chiefly color) ; 29 cm

Other Title:

Fluorescence diagnosis and PDT

Place of Publication:

Wien ; New York : Springer, [2003]

Summary:

This book is the most up-to-date publication on fluorescence diagnostic (FDAP) and photodynamic therapy (PDT) methods used in dermatology. Both techniques are presently world wide introduced as standards for the delineation and the treatment of cutaneous precancerous stages and tumors, which show steadily increasing numbers due to e.g. more frequent sun exposure. Summarizing experiences on more than 5.000 treated patients, it offers a comprehensive information on every aspect of skin tumor detection and treatment. The main part of the book focuses on the clinical aspects giving detailed descriptions on skin tumor detection as well as photodynamic treatment of selected diseases (solar keratoses, basal cell carcinomas, squamous cell carcinomas, Bowen's disease, psoriasis lesions, etc.). The clinically oriented chapters are supplemented by practical guidelines for PDT and FDAP. The included atlas is comprised of 270 high quality color figures allowing daily use as a handbook.

Contents:

A Introduction and Historical Landmarks 1

A.1 Definition of the Photodynamic Action 1

A.2 Optimum Photosensitizing Agent for Photodynamic Action 1

A.2.1 Hematoporphyrin Derivative (HpD) and Porfimer Sodium (Photofrin) 1

A.2.2 Porphines 2

A.2.3 Phthalocyanines 2

A.2.4 Chlorine Derivatives 2

A.2.5 Lutetium texaphyrin (Lu-Tex) 3

A.2.6 Porphycenes 3

A.2.7 Other Photosensitizers 3

A.2.8 Endogenous Porphyrins 3

A.3 Definition of Fluorescence Detection with ALA-Induced Porphyrins (FDAP) 4

A.3.1 Physical Background of the Fluorescence in FDAP 6

A.4 Mechanisms of Action in PDT 7

B [delta]-Aminolevulinic Acid (ALA) 9

B.1 Chemistry of ALA and ALA Methylester (ALA) 9

B.2 Metabolism of ALA 10

B.3 Pharmacodynamics of ALA 12

B.3.1 Systemic Administration of ALA 12

B.3.2 Topical Application of ALA 16

C Light Used in FDAP and PDT 19

D Unresolved Issues in FDAP and PDT 21

E Fluorescence Detection of ALA-induced Porphyrins (FDAP) 23

E.1 FDAP: Evaluation of the ALA-Induced Fluorescence in Skin Diseases 23

F Ex vivo

Investigations on ALA-induced Porphyrins 33

F.1 Porphyrin Accumulation in Cells (in vitro) 33

F.2 Porphyrin Accumulation in Skin Tumors, Colon and Bronchial Carcinomas after Administration of ALA (ex vivo) 34

G In vivo

Investigations on ALA-Induced Porphyrin/FDAP 37

G.1 FDAP: Kinetics of ALA-Induced Porphyrins in Human Cutaneous Tumors, Psoriasis Lesions and Normal Skin 37

G.2 FDAP: Kinetics of Porphyrin Accumulation in Solar Keratoses: ALA versus ALA Methylester 39

G.3 FDAP: Use of the in vivo

Fluorescence for Surgical Planning 43

G.4 FDAP: Evaluation of the Optimum Photosensitizing Substance or its Prodrug 44

G.5 FDAP: Evaluation of the Optimum Exciting Light Source 46

G.6 FDAP: Correlation of in vivo

Tumor Fluorescence and Histopathology 46

G.7 FDAP: Course of FDAP in Relation to the Number of PDT-Sessions 50

H The Clinical Use of FDAP 55

H.1 FDAP in Clinically Well-defined Tumors 55

H.2 FDAP in Clinically Ill-defined Lesions 56

H.3 FDAP in Pretreated or Damaged Skin 59

H.4 Limitations of FDAP 61

H.5 Usefulness of FDAP in Guiding Tumor Therapies 62

I Photodynamic Therapy in Cutaneous Diseases 65

I.1 PDT: Evaluation of the Efficacy in Solar Keratoses 65

I.2 PDT: Evaluation of the Efficacy in Bowen's Disease 71

I.3 PDT: Evaluation of the Efficacy in Basal Cell Carcinoma 72

I.4 PDT: Evaluation of the Efficacy in Squamous Cell Carcinoma 76

I.5 PDT: Evaluation of the Efficacy in Psoriatic Lesions 78

I.6 PDT: Evaluation of the Efficacy in Selected Cutaneous Diseases 84

I.6.1 PDT in Skin Cancers and Precanceroses Others than Discussed Above 85

I.6.2 PDT in Tumors of the Oral Mucosa 86

I.6.3 PDT in Non-neoplastic Skin Diseases 86

I.6.4 PDT in Non-dermatological Indications 89

I.7 PDT: Evaluation of the Optimum Photosensitizing Substance or its Prodrug 89

I.8 PDT: Evaluation of the Optimum Exciting Light Source 91

J.1 FDAP: Indications and Limits 97

J.2 PDT: Indications and Limits 101

J.3 Safety and Tolerability of ALA-PDT 107

J.4 Regulatory Affairs Concerning Aminolevulinic Acid 108

J.5 Regulatory Affairs Concerning Aminolevulinic Acid Methylester 108.

Notes:

Includes bibliographical references (pages [115]-124).

ISBN:

3211838279

OCLC:

53286108