Regulation of alternative splicing / Philippe Jeanteur, ed.

Format:

Book

Contributor:

Jeanteur, Ph. (Philippe)

Rosengarten Family Fund.

Series:

Progress in molecular and subcellular biology ; 31.

Progress in molecular and subcellular biology ; 31

Language:

English

Subjects (All):

Genetic recombination.

Exons (Genetics).

Split genes.

Exons.

Alternative Splicing.

Medical Subjects:

Exons.

Alternative Splicing.

Physical Description:

xiii, 245 pages : 26 fig. ; 25 cm.

Place of Publication:

Berlin ; New York : Springer, 2003.

Summary:

The generality and quantitative extent of alternative splicing have only now begun to be fully appreciated. The first draft of the complete human genome led to the surprisingly low figure of about 32,000 genes. The extensive use of alternative splicing and its consequences in terms of coding capacity could account for this discrepancy and help fill the complexity gap between the genome and the proteome. After a computer-based assessment of the frequency of alternative splicing, this book addresses mechanistic aspects followed by examples of its involvement in important cellular processes. Finally, it raises the possibility of artificial modulation of alternative splicing by antisense nucleotides.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

3540438335

OCLC:

55666124