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Epigenetics in cancer prevention : early detection and risk assessment / edited by Mukesh Verma, Barbara K. Dunn, and Asad Umar.

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Format:
Book
Conference/Event
Contributor:
Verma, Mukesh.
Dunn, Barbara K.
Umar, Asad.
National Cancer Institute (U.S.). Division of Cancer Prevention.
Conference Name:
Epigenetics in Cancer Prevention: Early Detection and Risk Assessment Workshop (2001 : Bethesda, Md.)
Series:
Annals of the New York Academy of Sciences ; v. 983.
Annals of the New York Academy of Sciences ; v. 983
Language:
English
Subjects (All):
Cancer--Genetic aspects--Congresses.
Cancer.
Cancer--Genetic aspects.
Cancer--Prevention--Congresses.
Cancer--Prevention.
Cancer--Risk factors--Congresses.
Cell Transformation, Neoplastic--genetics.
Cancer--Risk factors.
Neoplasms--genetics.
Neoplasms--prevention & control.
Medical Subjects:
Cell Transformation, Neoplastic--genetics.
Neoplasms--genetics.
Neoplasms--prevention & control.
Genre:
Conference papers and proceedings.
Physical Description:
x, 330 pages : illustrations ; 24 cm.
Place of Publication:
New York : New York Academy of Sciences, [2003]
Contents:
Preface: Epigenetics in Cancer Prevention, with Emphasis on Early Detection and Risk Assessment / Peter Greenwald, Mukesh Verma ix
Epigenetics in Cancer Prevention: Early Detection and Risk Assessment: Introduction / Barbara K. Dunn, Mukesh Verma, Asad Umar 1
Part I. The Basic Mechanism of Epigenetics-Mediated Regulation
Chromatin as a Tool for the Study of Genome Function in Cancer / Fyodor D. Urnov 5
Unanswered Questions about the Role of Promoter Methylation in Carcinogenesis / Timothy H. Bestor 22
Hypomethylation: One Side of a Larger Picture / Barbara K. Dunn 28
Genetic and Epigenetic Mosaicism in Cancer Precursor Tissues / Benjamin Tycko 43
Epigenetic Control during Lymphoid Development and Immune Responses: Aberrant Regulation, Viruses, and Cancer / Kathrin Muegge, Howard Young, Francis Ruscetti, Judy Mikovits 55
Epigenetics: The Role of Methylation in the Mechanism of Action of Tumor Suppressor Genes / Pawan K. Jain 71
Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code / Sam Thiagalingam, Kuang-Hung Cheng, Hyunjoo J. Lee, Nora Mineva, Arunthathi Thiagalingam, Jose F. Ponte 84
Genome-Wide Analysis of Epigenetics in Cancer / Maxwell P. Lee 101
Part II. Technical Approaches for Analysis
The Development of CpG Island Methylation Biomarkers Using Restriction Landmark Genomic Scanning / Dominic J. Smiraglia, Christoph Plass 110
Sensitive Detection of DNA Methylation / Susan E. Cottrell, Peter W. Laird 120
Methylation-Sensitive Representational Difference Analysis and Its Application to Cancer Research / Atsushi Kaneda, Daiya Takai, Michio Kaminishi, Eriko Okochi, Toshikazu Ushijima 131
Cancer Biomarker Validation: Standards and Process: Roles for the National Institute of Standards and Technology (NIST) / Peter E. Barker 142
Part III. Exogenous Factors Affecting Epigenetic Regulation
Epigenetics and the Environment / Jessica E. Sutherland, Max Costa 151
Environmental Exposure, DNA Methylation, and Gene Regulation: Lessons from Diethylstilbesterol-Induced Cancers / Shuanfang Li, Stephen D. Hursting, Barbara J. Davis, John A. McLachlan, J. Carl Barrett 161
Viral Genes and Methylation / Mukesh Verma 170
Epidemiologic Considerations to Assess Altered DNA Methylation from Environmental Exposures in Cancer / Lee E. Moore, Wen-Yi Huang, Joyce Chung, Richard B. Hayes 181
Diet and DNA Methylation Interactions in Cancer Prevention / Sharon A. Ross 197
Part IV. Epigenetics, Cancer, and Cancer Prevention
Promoter Hypermethylation as an Epigenetic Component in Type I and Type II Endometrial Cancers / John I. Risinger, G. Larry Maxwell, Andrew Berchuck, J. Carl Barrett 208
Epigenetics in Carcinogenesis and Cancer Prevention / Peter A. Jones 213
Histone Acetylation and Gastrointestinal Carcinogenesis / Wataru Yasui, Naohide Oue, Shigehiro Ono, Yoshitsugu Mitani, Reiko Ito, Hirofumi Nakayama 220
Epigenetics in High-Grade Astrocytomas: Opportunities for Prevention and Detection of Brain Tumors / Waldemar Debinski, Denise Gibo, Akiva Mintz 232
Aberrant DNA Methylation in Ovarian Cancer: Is There an Epigenetic Predisposition to Drug Response? / Susan H. Wei, Robert Brown, Tim H.-M. Huang 243
DNA Methylation, a Biomarker for Colorectal Cancer: Implications for Screening and Pathological Utility / Adrian M. Jubb, Phil Quirke, Adam J. Oates 251
Epigenetic Regulation of ARHI in Breast and Ovarian Cancer Cells / Yinhua Yu, Satoshi Fujii, Jiuhong Yuan, Robert Z. Luo, Lin Wang, Jiaju Bao, Mitsutaka Kadota, Mitsuo Oshimura, Sharon R. Dent, Jean-Pierre Issa, Robert C. Bast, Jr 268
Epigenetic Changes: Potential Therapeutic Targets / Thea Kalebic 278
DNA Methylation as a Cancer-Specific Biomarker: From Molecules to Populations / Arti Patel, John D. Groopman, Asad Umar 286
Early Detection and Risk Assessment: Proceedings and Recommendations from the Workshop on Epigenetics in Cancer Prevention / Mukesh Verma, Barbara K. Dunn, Sharon Ross, Pawan Jain, Wendy Wang, Richard Hayes, Asad Umar 298.
Notes:
Includes bibliographical references and index.
ISBN:
1573314307
1573314315
OCLC:
51511656

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