Tissue engineering of cartilage and bone / [editors, Gregory Bock, Jamie Goode].

Format:

Book

Contributor:

Bock, Gregory.

Goode, Jamie.

Series:

Novartis Foundation symposium ; 249.

Novartis Foundation symposium ; 249

Language:

English

Subjects (All):

Bone regeneration.

Joints--Diseases.

Joints.

Cartilage--Diseases.

Cartilage.

Animal cell biotechnology.

Tissue culture.

Bone Regeneration.

Joint Diseases.

Cartilage Diseases.

Biotechnology.

Models, Animal.

Tissue Culture.

Tissue Engineering.

Medical Subjects:

Bone Regeneration.

Joint Diseases.

Cartilage Diseases.

Biotechnology.

Models, Animal.

Tissue Culture.

Tissue Engineering.

Genre:

Conference papers and proceedings.

Physical Description:

ix, 251 pages : illustrations ; 24 cm.

Place of Publication:

New York : J. Wiley, 2003.

Summary:

Tissue engineering takes advantages of the combined use of cultured living cells and three-dimensional scaffolds to reconstruct adult tissues that are absent or malfunctioning. This book brings together scientists and clinicians working on a variety of approaches for regenerating of damaged or lost cartilage and bone to assess the progress of this dynamic field. In its early days, tissue engineering was driven by material scientists who designed novel bio-resorbable scaffolds on which to seed cells and grow tissues. This ground-breaking work generated high expectations, but there have been significant stumbling blocks holding back the widespread use of these techniques in the clinic. These challenges, and potential ways of overcoming them, are given thorough coverage in the discussions that follow each chapter. The key questions addressed in this book include the following. How good must cartilage repair be for it to be worthwhile? What is the best source of cells for tissue engineering of both bone and cartilage? Which are the most effective cell scaffolds? What are the best preclinical models for these technologies? And when it comes to clinical trials, what sort of outcome measures should be used? With contributions from some of the leading experts in this field, this timely publication will prove essential reading for anyone with an interest in the field of tissue engineering.

Contents:

Tissue engineering of cartilage: do we need it, can we do it, is it good and can we prove it? / L. Stefan Lohmander 2

Embryonic development and the principles of tissue engineering / Arnold I. Caplan 17

The fundamentals of tissue engineering: scaffolds and bioreactors / Gordana Vunjak-Novakovic 34

Tissue-engineered versus native cartilage: linkage between cellular mechano-transduction and biomechanical properties / Jennifer H. Lee, John Kisiday, Alan J. Grodzinsky 52

From the preclinical model to the patient / Ernst B. Hunziker 70

Mesenchymal stem cell therapy in joint disease / Frank P. Barry 86

Differentiated chondrocytes for cartilage tissue engineering / J. Huckle, G. Dootson, N. Medcalf, S. McTaggart, E. Wright, A. Carter, R. Schreiber, B. Kirby, N. Dunkelman, S. Stevenson, S. Riley, T. Davisson, A. Ratcliffe 103

Mesenchymal stem cells and bioceramics: strategies to regenerate the skeleton / Hajime Ohgushi, Jun Miyake, Tetsuya Tateishi 118

Bone marrow stromal cells and their use in regenerating bone / Ranieri Cancedda, Maddalena Mastrogiacomo, Giordano Bianchi, Anna Derubeis, Anita Muraglia, Rodolfo Quarto 133

Studying the effect of different macrostructures on in vitro cell behaviour and in vivo bone formation using a tissue engineering approach / R. J. Dekker, C. A. van Blitterswijk, I. Hofland, P. J. Engelberts, J. Li, J. D. de Bruijn 148

Cartilage repair with chondrocytes: clinical and cellular aspects / Anders Lindahl, Mats Brittberg, Lars Peterson 175

Qualitative and quantitative in vivo assessment of articular cartilage using magnetic resonance imaging / Elizabeth O'Byrne, Theodore Pellas, Didier Laurent 190

Hyaluronan-based scaffolds (Hyalograft C) in the treatment of knee cartilage defects: preliminary clinical findings / Alessandra Pavesio, Giovanni Abatangelo, Anna Borrione, Domenico Brocchetta, Anthony P. Hollander, Elizaveta Kon, Francesca Torasso, Stefano Zanasi, Maurilio Marcacci 203

Quantitative analysis of repair tissue biopsies following chondrocyte implantation / Anthony P. Hollander, Sally C. Dickinson, Trevor J. Sims, Carlo Soranzo, Alessandra Pavesio 218

General discussion II Tissue engineering using recombinant human BMP2 234.

Notes:

"Symposium on tissue engineering of cartilage and bone, held at the Novartis Foundation, London, 9-11 April 2002"--Contents p.

Includes bibliographical references and index.

ISBN:

0470844817

OCLC:

51446154