Experimental therapeutics / edited by Martin R. Wilkins.

Format:

Book

Contributor:

Wilkins, Martin R., 1956-

Series:

Postgraduate medical science

Postgraduate medical sciences series

Language:

English

Subjects (All):

Therapeutics, Experimental.

Drug Design.

Pharmacogenetics.

Therapies, Investigational.

Medical Subjects:

Drug Design.

Pharmacogenetics.

Therapies, Investigational.

Physical Description:

xii, 236 pages : illustrations ; 26 vm.

Place of Publication:

London ; New York : Martin Dunitz ; Independence, KY : Distributed in the USA by Fulfilment Center, Taylor & Francis, [2003]

Summary:

The Postgraduate Medical Sciences series is designed to appeal to: physicians at the specialist registrar level who are undergoing specialist training in the relevant medical disciplines, scientists or doctors who are embarking on clinical or laboratory-based research and health professionals who wish to keep up to date with the scientific developments in their field.

Contents:

Section 1 Drug Discovery and Development

1. The clinical pharmacologist's view: drug discovery and early development / Sir Colin Dollery 3

2. The toxicologist's view: non-clinical safety assessment / Anthony Lynch, John Connelly 25

3. The regulator's view: regulatory requirements for marketing authorizations for new medicinal products in the European Union / Rashmi R Shah, Sarah K Branch, Christopher Steele 51

Section 2 Clinical Pharmacology

4. Principles of pharmacokinetics / Andrew G Renwick 79

5. The use of pharmacogenetics to maximize therapeutic benefit / Christian Meisel, Matthias Schwab 107

6. Drug chirality: pharmacology in three dimensions / Andrew J Hutt 125

7. Surrogate endpoints / James J Oliver, David J Webb 145

8. Positron emission tomography as a tool in pharmacology: lessons from neuroscience / Eugenii A Rabiner, Paul M Grasby 167

Section 3 Novel Therapies

9. Targeting nuclear receptors: PPARs as targets for drug design / Colin NA Palmer, Martin R Wilkins 179

10. The use of antisense oligonucleotides as therapeutic agents / Punit Ramrakha 195

11. Gene therapy: theoretical and practical aspects / Rebecca Kristeleit, Martin R Wilkins 211.

Notes:

Includes bibliographical references and index.

ISBN:

1841842907

OCLC:

52639379