Microbial genomics and drug discovery / edited by Thomas J. Dougherty, Steven J. Projan.

Format:

Book

Contributor:

Dougherty, Thomas J.

Projan, Steve.

Language:

English

Subjects (All):

Microbial genetics.

Gene mapping.

Genomics.

Pharmacogenomics.

Drug development.

Genetics, Microbial.

Pharmacogenetics.

Drug Design.

Medical Subjects:

Genetics, Microbial.

Genomics.

Pharmacogenetics.

Drug Design.

Physical Description:

xi, 243 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2003]

Summary:

Exploring innovative routes of drug discovery in the postgenomic era, this reference examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates -- exploring potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process. Clearly illustrates the use of pathway tools in a genomics-based drug discovery project. Microbial Genomics and Drug Discovery describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics...develop novel antibacterial compounds to combat drug resistance...detect side effects at earlier stages in the drug discovery process...evaluate drug candidates before the initiation of clinical trials...and perform broad-based and comprehensive cell testing in efficient and high-throughput formats using phenotype arrays.

Contents:

1. Global Aspects of Antibiotic Resistance / Julian Davies 1

2. Genomics of Bacterial Pathogens / Steven R. Gill, Karen E. Nelson, Claire M. Fraser 9

3. Bioinformatics, Genomics, and Antimicrobial Drug Discovery / Brian A. Dougherty, Daniel B. Davison 27

4. The Pathway Tools Software and Its Role in Antimicrobial Drug Discovery / Peter D. Karp 43

5. Genomic Strategies in Antibacterial Drug Discovery / Christopher P. Gray, Wolfgang Keck 55

6. Genomics-Based Approaches to Novel Antimicrobial Target Discovery / Thomas J. Dougherty, John F. Barrett, Michael J. Pucci 71

7. Pathogenesis Genes as Novel Targets / Andrea Marra 97

8. Application of Genomics to the Discovery of New Drugs Against Tuberculosis / Richard A. Slayden, Dean C. Crick, Michael R. McNeil, Patrick J. Brennan 111

9. Phenotype MicroArrays: Their Use in Antibiotic Discovery / Barry R. Bochner 135

10. Microbial Proteomics: New Approaches for Therapeutic Vaccines and Drug Discovery / C. Patrick McAtee 147

11. Surrogate Ligand-Based Assay Systems for Discovery of Antibacterial Agents for Genomic Targets / Dale J. Christensen, Paul T. Hamilton 173

12. Expression Profiling Uses in Antibacterial Chemotherapy Development / Paul M. Dunman, Steven J. Projan 187

13. Using Fungal Genomes for the Discovery, Development, and Clinical Application of Novel and Current Antifungal Therapeutics / Todd A. Black, Joan K. Brieland, Jonathan Greene, Catherine Hardalo, Scott S. Walker, Guillaume Cottarel 201

14. Genomics in Novel Natural Products Generation / Zhiqiang An, William R. Strohl 221.

Notes:

Includes bibliographical references and index.

ISBN:

0824740416

OCLC:

52513079