Ocular neuroprotection / edited by Leonard A. Levin, Adriana Di Polo.

Format:

Book

Contributor:

Levin, Leonard A.

Di Polo, Adriana.

Language:

English

Subjects (All):

Eye--Diseases--Chemotherapy.

Eye.

Eye--Diseases.

Nervous system--Degeneration--Prevention.

Nervous system.

Eye Diseases--therapy.

Nervous System--physiopathology.

Nervous system--Degeneration.

Medical Subjects:

Eye Diseases--therapy.

Nervous System--physiopathology.

Physical Description:

xi, 322 pages : illustrations ; 24 cm

Place of Publication:

New York : Marcel Dekker, [2003]

Contents:

I. In Vitro Models

1. Culture of Retinal Neurons / James D. Lindsey 1

II. In Vivo Models of Optic Nerve Damage

2. Crush Injury of the Optic Nerve / Michal Schwartz, Eti Yoles 13

3. Intraocular Pressure Elevation: Vein Cauterization / Sansar C. Sharma 23

4. Intraocular Pressure Elevation: Injecting Hypertonic Saline into Episcleral Veins / John C. Morrison, Elaine C. Johnson, Lijun Jia, William O. Cepurna 31

5. Intraocular Pressure Elevation: Laser Photocoagulation of the Trabecular Meshwork / B'Ann T. Gabelt, James N. Ver Hoeve, Paul L. Kaufman 47

III. In Vivo Models of Retinal Damage

6. Light-Induced Retinal Degeneration / Daniel T. Organisciak, R. M. Darrow, L. S. Barsalou 85

7. Retinal Detachment / Ward M. Peterson 109

8. Retinal Ischemia / Manuel Vidal-Sanz, Maria P. Lafuente, Inmaculada Selles-Navarro, Maria E. Rodriguez, Sergio Mayor-Torroglosa, Maria P. Villegas-Perez 129

IV. Neuroprotective Strategies

9. Drug Delivery / Robert W. Nickells, Cassandra L. Schlamp 153

10. Recombinant Viral Vectors / Przemyslaw Sapieha, Adriana Di Polo 167

V. Analysis of Neuronal Survival and Function

11. Quantification of Retinal Cells / Christine A. Curcio, Kenneth R. Sloan 189

12. Ex Vivo and Whole-Mount Retinal Preparations / Arthur J. Weber 205

13. Detection of Single-Cell Apoptosis / William G. Tatton, Ruth M. E. Chalmers-Redman, Nadine A. Tatton 225

14. Imaging of Retinal Ganglion Cells / Joshua P. Vrabec, Leonard A. Levin 241

15. Evaluation of Retinal Function: Electroretinography / Marc Hebert, Pierre Lachapelle 249

VI. Clinical Trials

16. Evaluation of Visual Outcome / Pamela A. Sample 273

17. Clinical Trials in Neuroprotection / Scott M. Whitcup 291

18. Regulatory Issues in Clinical Trials / Anthony C. Arnold 303.

Notes:

Includes bibliographical references and index.

ISBN:

082474070X

OCLC:

52995866