DNA topoisomerases in cancer therapy : present and future / edited by Toshiwo Andoh.

Format:

Book

Contributor:

Andoh, Toshiwo.

Language:

English

Subjects (All):

DNA topoisomerases--Inhibitors--Therapeutic use.

DNA topoisomerases.

Cancer--Chemotherapy.

Cancer.

Topoisomerase Inhibitors.

Drug Delivery Systems.

Neoplasms--drug therapy.

Medical Subjects:

Topoisomerase Inhibitors.

Drug Delivery Systems.

Neoplasms--drug therapy.

Physical Description:

xii, 202 pages : illustrations (some color) ; 24 cm

Place of Publication:

New York : Kluwer Academic/Plenum Publishers, [2003]

Contents:

Chapter 1 Reflections on an accidental discovery / James C. Wang 1

Chapter 2 Mechanisms of topoisomerase I inhibition by anticancer drugs / Yves Pommier, Juana Barcelo, Takahisa Furuta, Haruyuki Takemura, Olivier Sordet 15

Chapter 3 Mechanism of action of topoisomerase II-targeted anticancer drugs / Kenneth D. Bromberg, Neil Osheroff 53

Chapter 4 Degradation of topoisomerase cleavable complexes / Leroy F. Liu 79

Chapter 5 Yeast as a model system in the analysis of DNA topoisomerase I poisons / Herve R. Jacquiau, Mary-Ann Bjornsti 89

Chapter 6 Understanding the action of drugs targeting TOP2: Yeast based systems for unraveling drug mechanisms / Mobeen Malik, John L. Nitiss 109

Chapter 7 Cellular resistance to DNA topoisomerase I-targeting drugs / Kae Yanase, Toshiwo Andoh 129

Chapter 8 Development of new topoisomerase I-targeting compounds as candidate anticancer drugs / Yves Pommier, ZhiYong Liao, LingHua Meng 145

Chapter 9 Development of new topoisomerase II-targeting compounds as candidate anticancer drugs / Toshiwo Andoh, Ken Umemura, Kae Yanase, Takao Yamori 167.

Notes:

Includes bibliographical references and index.

ISBN:

0306477440

OCLC:

51892843