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Essential cell biology : an introduction to the molecular biology of the cell / Bruce Alberts ... [and others].

Chemistry Library - Books QH581.2 .E78 2004 1 v. + CD-ROM
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Format:
Book
Contributor:
Alberts, Bruce.
Classes of 1883 and 1884 Fund.
Alumni and Friends Memorial Book Fund.
Language:
English
Subjects (All):
Cytology.
Molecular biology.
Biochemistry.
Cell Biology.
Molecular Biology.
Medical Subjects:
Cell Biology.
Molecular Biology.
Biochemistry.
Physical Description:
1 volume (various pagings) : illustrations (some color) ; 29 cm + 1 CD-ROM (4 3/4 in.)
Edition:
Second edition.
Place of Publication:
New York : Garland Science Pub., [2004]
Summary:
"Essential Cell Biology," Second Edition contains basic, core knowledge about how cells work. It has a proven track record in providing students with a conceptual and accessible grounding in cell biology. The text and figures have been prepared to be easy-to-follow, accurate, clear and engaging for the introductory student. Each section follows logically from the previous one, telling a story, rather than being a collection of facts. Questions integrated throughout each chapter encourage the reader to pause, think about what they have read, and attempt to apply the new knowledge in ways that test their understanding. Based on user feedback, the Second Edition now offers increased coverage of genetics and more experimental background. It is completely up-to-date.
Contents:
Panel 1-1 Light and electron microscopy 8
Panel 1-2 Cells: the principal features of animal, plant, and bacterial cells 25
How We Know: Life's common mechanisms 30
Chapter 2 Chemical Components of Cells 39
How We Know: What are macromolecules? 60
Panel 2-1 Chemical bonds and groups 66
Panel 2-2 The chemical properties of water 68
Panel 2-3 An outline of some of the types of sugars 70
Panel 2-4 Fatty acids and other lipids 72
Panel 2-5 The 20 amino acids found in proteins 74
Panel 2-6 A survey of the nucleotides 76
Panel 2-7 The principal types of weak noncovalent bonds 78
Chapter 3 Energy, Catalysis, and Biosynthesis 83
Panel 3-1 Free energy and biological reactions 96
How We Know: Using kinetics to model and manipulate metabolic pathways 103
Chapter 4 Protein Structure and Function 119
Panel 4-1 A few examples of some general protein functions 120
How We Know: Probing protein structure 129
Panel 4-2 Four different ways of depicting a small protein 132
Panel 4-3 Cell breakage and initial fractionation of cell extracts 160
Panel 4-4 Protein separation by chromatography 162
Panel 4-5 Protein separation by electrophoresis 163
Panel 4-6 Making and using antibodies 164
Chapter 5 DNA and Chromosomes 169
How We Know: Genes are made of DNA 172
Chapter 6 DNA Replication, Repair, and Recombination 195
How We Know: Finding replication origins 198
Chapter 7 From DNA to Protein: How Cells Read the Genome 229
How We Know: Cracking the genetic code 246
Chapter 8 Control of Gene Expression 267
How We Know: Gene regulation
the story of eve 282
Chapter 9 How Genes and Genomes Evolve 293
How We Know: Counting genes 314
Chapter 10 Manipulating Genes and Cells 323
How We Know: Sequencing the human genome 334
Chapter 11 Membrane Structure 365
How We Know: Measuring membrane flow 384
Chapter 12 Membrane Transport 389
How We Know: Squid reveal secrets of membrane excitability 414
Chapter 13 How Cells Obtain Energy from Food 427
Panel 13-1 Details of the 10 steps of glycolysis 432
How We Know: Unraveling the citric acid cycle 442
Panel 13-2 The complete citric acid cycle 450
Chapter 14 Energy Generation in Mitochondria and Chloroplasts 453
How We Know: How chemiosmotic coupling drives ATP synthesis 460
Panel 14-1 Redox potentials 471
Chapter 15 Intracellular Compartments and Transport 497
How We Know: Tracking protein and vesicle transport 520
Chapter 16 Cell Communication 533
How We Know: Untangling cell signaling pathways 561
Chapter 17 Cytoskeleton 573
How We Know: Pursuing motor proteins 586
Chapter 18 Cell-Cycle Control and Cell Death 611
How We Know: Discovery of cyclins and Cdks 618
Chapter 19 Cell Division 637
Panel 19-1 The principal stages of M phase in an animal cell 642
How We Know: Building the mitotic spindle 646
Chapter 20 Genetics, Meiosis, and the Molecular Basis of Heredity 659
How We Know: Reading genetic linkage maps 682
Panel 20-1 Some essentials of classical genetics 685
Chapter 21 Tissues and Cancer 697
Panel 21-1 The cell types and tissues from which higher plants are constructed 700
How We Know: Making sense of the genes that are critical for cancer 734.
Notes:
Includes bibliographical references, glossary and index.
Local Notes:
Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.
Acquired for the Penn Libraries with assistance from the Classes of 1883 and 1884 Fund.
ISBN:
081533480X
OCLC:
52312215

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