Vascular cognitive impairment : preventable dementia / edited by John V. Bowler and Vladimir Hachinski.

Format:

Book

Contributor:

Bowler, John V.

Hachinski, Vladimir.

Language:

English

Subjects (All):

Cerebrovascular disease--Complications.

Cerebrovascular disease.

Dementia.

Dementia, Vascular.

Medical Subjects:

Dementia, Vascular.

Physical Description:

xii, 350 pages : illustrations ; 25 cm

Place of Publication:

Oxford ; New York : Oxford University Press, 2003.

Summary:

Vascular dementia, caused by multiple small strokes, is the second most common cause of dementia after Alzheimer's disease. In recent years there has been a radical reappraisal of the concept of vascular dementia and a move away from an Alzheimer-based diagnostic paradigm towards one more appropriately tailored for vascular disease. Vascular Cognitive Impairment presents a new definition for this class of cerebrovascular process with an emphasis on early detection, prompt treatment, and the prevention of disease progression. Vascular Cognitive Impairment: preventable dementia presents an overview of the current state of our knowledge in this field. It reviews the historical background, prevalence, risk factors, and economic consequences of the condition. In addition, the book summarizes our knowledge of the pathological process, describing insight derived from genetic and imaging studies, before examining opportunities for early diagnosis, prevention and the options for management, both now, and as a result of ongoing clinical trials. With contributions from an expert team of international contributors, this book provides a comprehensive summary of the state-of-the-art in this field, providing a framework for a new understanding of a complex, disabling, but preventable condition.

Contents:

1 Current criteria for vascular dementia

a critical appraisal / J. V. Bowler, V. Hachinski 1

2 Historical evolution of the concept of vascular dementia / G. C. Roman 12

3 Prevalence and incidence patterns of vascular dementia / W. A. Rocca, D. S. Knopman 21

4 Evidence-based prognosis of vascular dementia: survival and rate of cognitive decline / H. C. Chui, W. Mack, A. Varpetian, D. Mungas 33

5 The cost of vascular cognitive impairment / K. Rockwood, M. Brown, J. D. Fisk 51

6 Histopathology / D. G. Munoz 57

7 Experimental models of vascular dementia: a focus on white matter disease and incomplete infarction / C. Sarti, L. Pantoni 76

8 Genetics of vascular dementia / H. S. Markus 93

9 Behavioral and psychological symptoms in vascular cognitive impairment / K. Rockwood, C. Shea 110

10 Cognitive patterns / D. W. Desmond 126

11 Measurement of cognition / S. H. Ferris 139

12 Neuropsychological differentiation of Alzheimer's disease and vascular dementia / P. S. Sachdev, J. C. L. Looi 153

13 Anatomical imaging / T. Erkinjuntti, T. Pohjasvaara 176

14 Cerebral blood flow and metabolism in vascular dementia / N. S. Ward, M. M. Brown 193

15 Neurochemical markers / M. Sjogren, K. Blennow, A. Wallin 208

16 Subtypes of vascular dementia and their pathogenesis: a critical overview / L. Pantoni 217

17 White matter changes in vascular dementia / P. Scheltens 230

18 Post-stroke dementia / H. Henon, F. Pasquier, D. Leys 239

19 Vasculitis, collagen vascular disease, and vascular dementia / N. Futrell 251

20 Vascular disorders and Alzheimer's disease / I. Skoog, D. Gustafson 260

21 Treatment of vascular dementias / D. Inzitari, M. Lamassa, L. Pantoni 277

22 Clinical trials in vascular dementia / J. Marler 293

23 Prevention / P. B. Gorelick 308

24 Vascular cognitive impairment

a new concept / J. V. Bowler, V. Hachinski 321.

Notes:

Includes bibliographical references and index.

ISBN:

0192632671

OCLC:

51315555