The practice of medicinal chemistry / edited by Camille G. Wermuth.

Format:

Book

Contributor:

Wermuth, C. G.

Rosengarten Family Fund.

Language:

English

Subjects (All):

Pharmaceutical chemistry.

Drugs--Design.

Drugs.

Chemistry, Pharmaceutical.

Medical Subjects:

Chemistry, Pharmaceutical.

Physical Description:

xiv, 768 pages : illustrations (some color) ; 29 cm

Edition:

Second edition.

Place of Publication:

San Diego, Calif. ; London : Academic Press, 2003.

Summary:

The Practice of Medicinal Chemistry, 2E, collects in one single volume the practical aspects of medicinal chemistry. The first edition was nicknamed 'The Bible' by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for, and design of, new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists with little or no background in medicinal chemistry. These chemists must acquire a good knowledge of medicinal chemistry during their first years in the pharmaceutical/drug discovery industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.

Contents:

Part I General Aspects of Medicinal Chemistry

1 A brief history of drugs: from plant extracts to DNA technology / Francois Chast 1

2 Medicinal chemistry: definition and objectives, the three main phases of drug activity, drug and disease classifications / Camille G. Wermuth 29

3 Measurement and expression of drug effects / Jean-Paul Kan 41

4 Drug targets: molecular mechanisms of drug action / Jean-Pierre Gies, Yves Landry 51

Part II Lead Compound Discovery Strategies

5 Strategies in the search for new lead compounds or original working hypotheses / Camille G. Wermuth 67

6 Natural products as pharmaceuticals and sources for lead structures / David Newman, Gordon Cragg, David Kingston 91

7 Basics of combinatorial chemistry / Cecile Vanier, Alain Wagner 111

8 The contribution of molecular biology to drug discovery / Kenton H. Zavitz, Adrian N. Hobden 121

9 Electronic screening: lead finding from database mining / Lothar Terfloth, Johann Gasteiger 131

10 High-speed chemistry libraries: assessment of drug-likeness / Alexander Polinsky 147

11 Web alert

using the internet for medicinal chemistry / David Cavalla 159

Part III Primary Exploration of Structure-Activity Relationships

12 Molecular variations in homologous series: vinylogues and benzologues / Camille G. Wermuth 173

13 Molecular variations based on isosteric replacements / Camille G. Wermuth 189

14 Conformational restrictions and/or steric hindrance in medical chemistry / Camille G. Wermuth 215

15 Conformational restriction and/or steric hindrance in medicinal chemistry / Andre Mann 233

16 Identical and non-identical twin drugs / Jean-Marie Contreras, Jean-Jacques Bourguignon 251

17 Optical isomerism in drugs / Camille G. Wermuth 275

18 Application strategies for the primary structure-activity relationship exploration / Camille G. Wermuth 289

Part IV Substituents and Functions: Qualitative and Quantitative Aspects of Structure-Activity Relationships

19 Specific substituent groups / Camille G. Wermuth 301

20 The role of functional groups in drug-receptor interactions / Peter Andrews 327

21 Compound properties and drug quality / Christopher A. Lipinki 341

22 Quantitative approaches to structure-activity relationships / Han van de Waterbeemd, Sally Rose 351

Part V Spatial Organization, Receptor Mapping and Molecular Modeling

23 Stereochemical aspects of drug action I: conformational restriction, steric hindrance and hydrophobic collapse / Daniel H. Rich 371

24 Pharmacophore identification and receptor mapping / Hans-Dieter Holtje 387

25 Three-dimensional quantitative structure-property relationships / Gabriele Cruciani 405

26 Protein crystallography and drug discovery / Jean-Michel Rondeau, Herman Schreuder 417

27 Protein homology modelling and drug discovery / Tom Blundell, Charlotte Deane 445

28 The transition from agonist to antagonist activity: symmetry and other considerations / David J. Triggle 459

29 Design of peptidomimetics / Hiroshi Nakanishi, Michael Kahn 477

Part VI Chemical Modifications Influencing the Pharmacokinetic Properties

30 The fate of xenobiotics in living organisms / Franz Belpaire, Marc G. Bogaert 501

31 Biotransformation reactions / Jacques Magdalou, Sylvie Fournel-Gigleux, Bernard Testa, Mohamed Ouzzine 517

32 Chemical mechanisms of toxicity: basic knowledge for designing safer drugs / Anne-Christine Macherey, Patrick M. Dansette 545

33 Designing prodrugs and bioprecursors / Camille G. Wermuth 561

34 Macromolecular carriers for drug targeting / Etienne H. Schacht, Katleen De Winne, Katty Hoste, Stefan vansteenkiste 587

Part VII Pharmaceutical and Chemical Formulation Problems

35 Preparation of water-soluble compounds through salt formation / P. Heinrich Stahl 601

36 Preparation of water-soluble compounds by covalent attachment of solubilizing moieties / Camille G. Wermuth 617

37 Drug solubilization with organic solvents, or using micellar solutions or other colloidal dispersed systems / P. Heinrich Stahl 631

38 Improvement of drug properties by cyclodextrins / Kaneto Uekama, Fumitoshi Hirayama 649

39 Chemical and physicochemical solutions to formulation problems / Camille G. Wermuth 675

Part VIII Development of New Drugs: Legal and Economic Aspects

40 Discover a drug substance, formulate and develop it to a product / Bruno Galli, Bernard Faller 687

41 Drug nomenclature / Sabine Kopp-Kubel 697

42 Legal aspects of product protection

what a medicinal chemist should know about patent protection / Maria Souleau 707

43 The consumption and production of pharmaceuticals / Bryan G. Reuben 723.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

0127444815 :

OCLC:

49741346