Functional tissue engineering / Farshid Guilak ... [and others], editors.

Format:

Book

Contributor:

Guilak, Farshid.

Language:

English

Subjects (All):

Tissue engineering.

Biomechanics.

Animal cell biotechnology.

Biomedical Engineering.

Tissue Culture.

Biocompatible Materials.

Medical Subjects:

Biomedical Engineering.

Tissue Culture.

Biocompatible Materials.

Physical Description:

xvi, 426 pages : illustrations ; 27 cm

Place of Publication:

New York : Springer, [2003]

Summary:

Tissue engineering is an exciting new field at the interface of engineering and biology that uses implanted cells, scaffolds, DNA, proteins, protein fragments, and inductive molecules to repair or replace injured or diseased tissues and organs. Functional Tissue Engineering marks the tremendous progress in biological and biomaterials aspects of this field that have been accomplished to date. Functional tissue engineering represents a relevant and exciting new discipline in the field of tissue engineering. Readers will get an overview designed to increase awareness among tissue engineers about the importance of restoring biomechanical function in the development of living tissue substitutes. Further, the chapter authors identify the critical structural and mechanical requirements needed for each construct and provide a framework for the development of functional criteria in the design, manufacture, and optimization of tissue-engineered constructs. Garnering the expertise of a select group of biomedical engineers, biologists, and clinicians, Functional Tissue Engineering is a necessary resource for students, investigators, and clinicians engaged in this dynamic and exciting area.

Contents:

Part I The Functional Properties of Native Tissues 1

1. How Does Nature Build a Tissue? / Stephen C. Cowin 3

2. Ligament Healing: Present Status and the Future of Functional Tissue Engineering / Savio L.-Y. Woo, Steven D. Abramovich, John C. Loh, Volker Musahl, James H.-C. Wang 17

3. Native Properties of Cardiovascular Tissues: Guidelines for Functional Tissue Engineering / Jay D. Hamphrey 35

4. Functional Properties of Native Articular Cartilage / Gerard A. Ateshian, Clark T. Hung 46

5. Excitability and Contractility of Skeletal Muscle: Measurements and Interpretations / John A. Faulkner, Robert G. Dennis 69

Part II Functional Requirements of Engineered Tissues 85

6. Functional Requirements for the Engineering of a Blood Vessel Substitute / Robert M. Nerem, Jan P. Stegemann 87

7. In Vivo Force and Strain of Tendon, Ligament, and Capsule / Kai-Nan An 96

8. Requirements for Biological Replacement of the Articular Cartilage at the Knee Joint / Thomas Andriacchi 106

9. Functional Requirements: Cartilage / Jack L. Lewis 117

Part III Design Parameters for Tissue Engineering 127

10. Design Parameters for Functional Tissue Engineering / Arnold I. Caplan 129

11. Tissue Engineering a Heart: Critical Issues / Michael V. Sefton, Robert Akins 139

12. Design Parameters for Engineering Bone Regeneration / Robert E. Guldberg, Angel O. Duty 146

13. Tissue Engineering of Bone: The Potential Uses of Gene Therapy for Difficult Bone Loss Problems / Brett Peterson, Jay R. Lieberman 162

14. Engineered Skeletal Muscle: Functional Tissues, Organs, and Interfaces / Robert G. Dennis 178

15. Bioengineering the Growth of Articular Cartilage / Stephen M. Klisch, Michael A. DiMicco, Anne Hoger, Robert L. Sah 194

Part IV Assessment of Function in Engineered Tissues 211

16. Functional Tissue Engineering: Assessment of Function in Tendon and Ligament Repair / David L. Butler, Matthew Dressler, Hani Awad 213

17. The Role of Mechanical Forces in Tissue Engineering of Articular Cartilage / J.C.Y. Hu, K.A. Athanasiou 227

18. Biomechanics of Native and Engineered Heart Valves Tissues / Michael S. Sacks 243

19. Assessment of Function in Tissue-Engineered Vascular Grafts / David N. Ka, Hai-Chao Han 258

20. Assessment of the Performance of Engineered Tissues in Humans Requires the Development of Highly Sensitive and Quantitative Noninvasive Outcome Measures / R.J. O'Keefe, S. Jotterman, E.M. Schwarz, J.M. Looney, G.S. Seo, J. Tamez-Pena, A. Boyd, S. Bukata, J. Monu, K. Parker 268

Part V Cell-Matrix Interactions in Functional Tissue Engineering 275

21. Functional Tissue Engineering and the Role of Biomechanical Signaling in articular Cartilage Repair / Farshid Guilak, Lori A. Seton 277

22. Regulation of Cellular Response to Mechanical Signals by Matrix Design / Craig A. Simmons, David J. Mooney 291

23. Artificial Soft Tissue Fabrication from Cell-Contracted Biopolymers / Robert T. Tranquillo, Brett C. Isenberg 305

24. Cytomechanics: Signaling to Mechanical Load in Connective Tissue Cells and Role in Tissue Engineering / Albert J. Banes, Michelle Wall, Joanne Gravin, Joanne Archambault 318

Part VI Bioreactors and the Role of Biophysical Stimuli in Tissue Engineering 335

25. The Role of Biomechanics in Analysis of Cardiovascular Diseases: Regulation of the Fluid Shear Response by Inflammatory Mediators / Geert W. Schmid-Schonbein, Shunichi Fukuda 337

26. A Full Spectrum of Functional Tissue-engineered Blood Vessels: From Macroscopic to Microscopic / F.A. Auger, G. Grenier, M. Remy-Zolghadri, L. Germain 347

27. Engineering Functional Cartilage and Cardiac Tissue: In Vitro Culture Parameters / Lisa A. Freed, Maria A. Rupnick, Dirk Schaefer, Gordana Vunjak-Novakovic 360

28. Tissue Engineering Skeletal Muscle / Paul E. Kosnik, Robert G. Dennis, Herman H. Vandenburgh 377

Part VII Regulatory and Clinical Issues in Tissue Engineering 393

29. From Concept Toward the Clinic: Preclinical Evaluation of Tissue-Engineered Constructs / Steven A. Goldstein 395

30. Trends in the FDA / Edith Richmond Schwartz 400.

Notes:

"With 133 figures."

Includes bibliographical references and index.

ISBN:

0387955534

OCLC:

50090184