Thermodynamics of biochemical reactions / Robert A. Alberty.

Format:

Book

Author/Creator:

Alberty, Robert A.

Contributor:

Anne and Joseph Trachtman Memorial Book Fund.

Language:

English

Subjects (All):

Thermodynamics.

Physical biochemistry.

Bioenergetics.

Physical Description:

ix, 397 pages : illustrations ; 29 cm

Place of Publication:

Hoboken, N.J. : Wiley-Interscience, [2003]

Summary:

An excellent teaching text and resource with modern examples and references to the primary literature, Thermodynamics of Biochemical Reactions emphasizes the fundamental equations of thermodynamics and their application to systems of biochemical reactions. This emphasis leads to new thermodynamic potentials that provide criteria for measuring spontaneous change and equilibrium under the conditions that exist in a living cell. The theme of the book is that Legendre transforms make the application of thermodynamics more convenient for the users. In Chapter 4, "Thermodynamics of Biochemical Reactions at Specified pH," for example, a Legendre transform is used to introduce pH and pMg as independent intensive variables. In Chapter 6, "Systems of Biochemical Reactions," the steady-state concentrations of various coenzymes are introduced as independent intensive variables in discussing systems of enzyme-catalyzed reactions. In Chapter 8, "Phase Equilibrium in Aqueous Systems," a Legendre transform is used to introduce the electric potential of a phase as an independent intensive variable. Each instance illustrates the author's belief that the choice of variables, while often regarded as an innocuous step, often plays a critical role in formulating a solution. Practicing researchers in pharmaceutical and biotechnical corporations, as well as graduate and upper-level undergraduate students in biophysical chemistry or biochemistry, will find Thermodynamics of Biochemical Reactions to be a peerless resource.

Contents:

Introduction to apparent equilibrium constants

Structure of thermodynamics

Chemical equilibrium in aqueous solutions

Thermodynamics of biochemical reactions at specified pH

Matrices in chemical and biochemical thermodynamics

Systems of biochemical reactions

Thermodynamics of binding of the ligands by proteins

Phase equilibrium in aqueous systems

Oxidation-reduction reactions

Calorimetry of biochemical reactions

Use of semigrand partition functions.

Notes:

Includes bibliographical references and index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Anne and Joseph Trachtman Memorial Book Fund.

ISBN:

0471228516

OCLC:

51242181