Stroke genetics / edited by Hugh S. Markus.

Format:

Book

Contributor:

Markus, Hugh S.

Rosengarten Family Fund.

Series:

Oxford medical publications

Language:

English

Subjects (All):

Cerebrovascular disease--Genetic aspects.

Cerebrovascular disease.

Stroke--genetics.

Genetic Diseases, Inborn.

Intracranial Hemorrhages--genetics.

Risk Factors.

Medical Subjects:

Stroke--genetics.

Genetic Diseases, Inborn.

Intracranial Hemorrhages--genetics.

Risk Factors.

Physical Description:

xii, 346 pages, 4 unnumbered pages of plates : illustrations (some color) ; 25 cm.

Place of Publication:

Oxford ; New York : Oxford University Press, 2003.

Summary:

Stroke is a major cause of death and the major cause of adult neurological disability in most of the world. Despite its importance on a population basis, research into the genetics of stroke has lagged behind that of many other disorders. However, the situation is now changing. An increasing number of single gene disorders causing stroke are being described, and there is growing evidence that polygenic factors are important in the risk of apparently "sporadic" stroke. Stroke Genetics provides an up to date review of the area, suitable for clinicians treating stroke patients, and both clinical and non-clinical researchers in the field of cerebrovascular disease. The full range of monogenic stroke disorders causing cerebrovascular disease, including ischaemic stroke, intracerebral haemorrhage, aneurysms and arteriovenous malformations, are covered. For each, clinical features, diagnosis, and genetics are described. Increasing evidence suggests that genetic factors are also important for the much more common multifactorial stroke; this evidence is reviewed along with the results of genetic studies in this area. Optimal and novel strategies for investigating multifactorial stroke, including the use of intermediate phenotypes such as intima-media thickness and MRI detected small vessel disease are reviewed. The book concludes by describing a practical approach to investigating patients with stroke for underlying genetic disorders. Also provided is a list of useful websites.

Contents:

2 Genetic principles and techniques / Andrew J. Catto, Angela M. Carter 31

3 Genetic epidemiology of stroke / James F. Meschia, Robert D. Brown, Jr. 53

4 Genetics of conventional stroke risk factors / Giuseppe A. Sagnella 69

5 Animal models of stroke: implications for genetic studies of human stroke / Speranza Rubattu, Bruna Gigante, Rosita Stanzione, Massimo Volpe 115

6 Monogenic causes of ischaemic stroke / Martin Dichgans 127

7 Polygenic ischaemic stroke including new genetic and statistical approaches / Ahamad Hassan, Hugh S. Markus 165

8 Investigating the genetics of polygenic ischaemic stroke using intermediate phenotypes / Paula Jerrard-Dunne, Ahamad Hassan, Hugh S. Markus 197

9 Genetics of intracerebral haemorrhage / Joost Haan 223

10 Genetics of subarachnoid haemorrhage and intracranial aneurysms / Wouter I. Schievink 243

11 Familial cerebral arteriovenous malformations / Pierre Labauge 267

12 The genetics of paediatric stroke / Fenella Kirkham, Mara Prengler 283

13 Investigating a patient with stroke for genetic causes / Hugh S. Markus 307

14 Useful web sites for stroke genetics / Hugh S. Markus 339.

Notes:

Includes bibliographical references.

Local Notes:

Acquired for the Penn Libraries with assistance from the Rosengarten Family Fund.

ISBN:

0198515863

OCLC:

51543789