Cardiac markers / edited by Alan H. B. Wu ; foreword by William E. Boden.

Format:

Book

Contributor:

Wu, Alan H. B.

Series:

Pathology and laboratory medicine (Unnumbered)

Pathology and laboratory medicine

Language:

English

Subjects (All):

Coronary heart disease--Serodiagnosis.

Coronary heart disease.

Biochemical markers.

Myocardial Infarction--diagnosis.

Angina, Unstable--physiopathology.

Biomarkers.

Heart Failure--diagnosis.

Myocardial Ischemia--diagnosis.

Troponin--diagnostic use.

Serodiagnosis.

Medical Subjects:

Myocardial Infarction--diagnosis.

Angina, Unstable--physiopathology.

Biomarkers.

Heart Failure--diagnosis.

Myocardial Ischemia--diagnosis.

Troponin--diagnostic use.

Physical Description:

xvii, 467 pages : illustrations ; 27 cm.

Edition:

Second edition.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

In this greatly enlarged and thoroughly updated edition of his much praised Cardiac Markers, Alan Wu and his contributors focus on the use of markers in the practice of cardiology and -- for the first time -- on the use of natriuretic peptides for congestive heart failure. Here, leading international authorities in clinical chemistry and laboratory medicine, cardiology, emergency medicine, and the in vitro diagnostics industry describe the state-of-the-art uses of cardiac markers when treating coronary artery disease, and discuss in detail how they may be optimally used in a clinical setting. The many new and updated chapters introduce new ischemic markers such as CRP, fatty acid binding protein, ischemia modified albumin, oxidized LDL, whole blood choline, and genetic polymorphisms that portend high risk for cardiovascular disease. The authors address analytical issues, assay development, cutoff concentrations, antibody selection schemes, point-of-care testing, in situ degradation of cardiac troponin, and updated clinical trials. They also discuss the emerging infectious disease etiology of heart disease, as well as the role of troponin in such non-ischemic diseases as renal failure, cardiac surgery, sepsis, myocarditis, and chemotherapeutic drug monitoring. Comprehensive and cutting-edge, Cardiac Markers, Second Edition not only offers physicians a complete guide to the use of cardiac markers in clinical practice, but also provides clinical laboratorians a close-up view of the new markers now becoming standard.

Contents:

Part I. Cardiac Markers in Clinical Practice

1 Early Detection of Myocardial Necrosis in the Emergency Setting and Utility of Serum Biomarkers in Chest Pain Unit Protocols / Andra L. Blomkalns, W. Brian Gibler 3

2 Management of Acute Coronary Syndromes / Constantine N. Aroney, James A. de Lemos 15

3 Evolution of Cardiac Markers in Clinical Trials / Alexander S. Ro, Christopher R. deFilippi 37

4 Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers: Practice and Promise / Robert H. Christenson, Hassan M. E. Azzazy 59

5 The Use of Cardiac Biomarkers to Detect Myocardial Damage Induced by Chemotherapeutic Agents / Eugene H. Herman, Steven E. Lipshultz, Victor J. Ferrans 87

6 The Use of Biomarkers to Provide Diagnostic and Prognostic Information Following Cardiac Surgery / Jesse E. Adams, III 111

Part II. Clinical Use for Cardiac Troponins

7 Cardiac Troponins: Exploiting the Diagnostic Potential of Disease-Induced Protein Modifications / Ralf Labugger, D. Kent Arrell, Jennifer E. Van Eyk 125

8 Cardiac Troponin Testing in Renal Failure and Skeletal Muscle Disease Patients / Fred S. Apple 139

9 Cardiac-Specific Troponins Beyond Ischemic Heart Disease / David Morrow 149

Part III. Analytical Issues for Cardiac Markers

10 Antibody Selection Strategies in Cardiac Troponin Assays / Alexei Katrukha 173

11 Interferences in Immunoassays for Cardiac Troponin / Kiang-Teck J. Yeo, Daniel M. Hoefner 187

12 Cardiac Marker Measurement by Point-of-Care Testing / Paul O. Collinson 199

13 Standardization of Cardiac Markers / Mauro Panteghini 213

14 Analytical Issues and the Evolution of Cutoff Concentrations for Cardiac Markers / Alan H. B. Wu 231

Part IV. Early Cardiac Markers of Myocardial Ischemia and Risk Stratification

15 Rationale for the Early Clinical Application of Markers of Ischemia in Patients with Suspected Acute Coronary Syndromes / Robert L. Jesse 245

16 Ischemia-Modified Albumin, Free Fatty Acids, Whole Blood Choline, B-Type Natriuretic Peptide, Glycogen Phosphorylase BB, and Cardiac Troponin / Alan H. B. Wu, Peter Crosby, Gary Fagan, Oliver Danne, Ulrich Frei, Martin Mockel, Joseph Keffer 259

17 C-Reactive Protein for Primary Risk Assessment / Gavin J. Blake, Paul M. Ridker 279

18 Prognostic Role of Plasma High-Sensitivity C-Reactive Protein Levels in Acute Coronary Syndromes / Luigi M. Biasucci, Antonio Abbate, Giovanna Liuzzo 291

19 Preanalytic and Analytic Sources of Variations in C-Reactive Protein Measurement / Thomas B. Ledue, Nader Rifai 305

20 Fatty Acid Binding Protein as an Early Plasma Marker of Myocardial Ischemia and Risk Stratification / Jan F. C. Glatz, Roy F. M. van der Putten, Wim T. Hermens 319

21 Oxidized Low-Density Lipoprotein and Malondialdehyde-Modified Low-Density Lipoprotein in Patients with Coronary Artery Disease / Paul Holvoet 339

Part V. Cardiac Markers of Congestive Heart Failure

22 Pathophysiology of Heart Failure / Johannes Mair 351

23 B-Type Natriuretic Peptide: Biochemistry and Measurement / Jeffrey R. Dahlen 369

24 B-Type Natriuretic Peptide in the Diagnoses and Management of Congestive Heart Failure / Ramin Tabbibizar, Alan Maisel 379

25 Monitoring Efficacy of Treatment with Brain Natriuretic Peptide / Emil D. Missov, Leslie W. Miller 397

26 N-Terminal Pro-B-Type Natriuretic Peptide / Torbjorn Omland, Christian Hall 411

Part VI. Role of Infectious Diseases and Genetics in Heart Disease

27 Infectious Diseases in the Etiology of Atherosclerosis and Acute Coronary Syndromes: Focus on Chlamydia pneumoniae / Martin Mockel 427

28 Polymorphisms Related to Acute Coronary Syndromes and Heart Failure: Potential Targets for Pharmacogenomics / Alan H. B. Wu 439.

Notes:

Includes bibliographical references and index.

ISBN:

1588290360

1592593852

OCLC:

50769550