Nathan and Oski's hematology of infancy and childhood / [edited by] David G. Nathan ... [and others].

Format:

Book

Contributor:

Nathan, David G., 1929-

Oski, Frank A.

Language:

English

Subjects (All):

Pediatric hematology.

Neonatal hematology.

Hematologic Diseases.

Child.

Infant.

Medical Subjects:

Hematologic Diseases.

Child.

Infant.

Physical Description:

2 volumes (xiv, 1864, xli pages, 8 unnumbered pages of plates) : illustrations (some color) ; 29 cm

Edition:

Sixth edition.

Other Title:

Hematology of infancy and childhood

Place of Publication:

Philadelphia, Pa. : Saunders, [2003]

Summary:

Presenting the New Edition of the classic reference on pediatric hematology and oncology. Comprehensively revised and updated, it continues to integrate lucid reviews of the pathophysiology of disease with detailed clinical guidance on its diagnosis and management. Drs. Nathan and Orkin joined by two new co-editors and an outstanding team of authors worked tirelessly to ensure that all the latest scientific advances appear in the 6th Edition. Nearly 50% of the chapters have been rewritten for the 6th Edition; the remaining chapters have been thoroughly revised and updated. Two new co-editors, Dr. Thomas Look and Dr. David Ginsburg, who contribute their expertise to the neoplastic diseases and coagulation sections. Important new coverage of transfusion medicine, stem cell transplantation protocols, the hematologic manifestations of pediatric AIDS/HIV, and more. The recently codified WHO classification for all lymphomas and leukemias.

Contents:

I. History 1

1. Pediatric Hematology in Historical Perspective / Wolf W. Zuelzer 3

II. Neonatal Hematology 17

2. The Neonatal Erythrocyte and Its Disorders / Carlo Brugnara, Orah S. Platt 19

3. Immune Hemolytic Disease / Helen G. Liley 56

4. Disorders of Bilirubin Metabolism / Peter F. Whitington, Estella M. Alonso 86

5. Developmental Hemostasis: Relevance to Newborns and Infants / Paul Monagle, Maureen Andrew 121

III. Bone Marrow Failure 169

6. The Anatomy and Physiology of Hematopoiesis / Steven C. Clark, Colin A. Sieff 171

7. Acquired Aplastic Anemia / Akiko Shimamura, Eva C. Guinan 256

8. Inherited Bone Marrow Failure Syndromes / Blanche P. Alter 280

9. Principles of Bone Marrow and Stem Cell Transplantation / Leslie Lehmann, W. Nicholas Haining, Eva C. Guinan 366

IV. Disorders of Erythrocyte Production 407

10. A Diagnostic Approach to the Anemic Patient / Frank A. Oski, Carlo Brugnara, David G. Nathan 409

11. Megaloblastic Anemia / V. Michael Whitehead, David S. Rosenblatt, Bernard A. Cooper 419

12. Disorders of Iron Metabolism and Sideroblastic Anemia / Nancy C. Andrews 456

13. The Porphyrias / Shigeru Sassa, Atallah Kappas 498

V. Hemolytic Anemias 519

14. Autoimmune Hemolytic Anemia / Russell E. Ware 521

15. Disorders of the Erythrocyte Membrane / Patrick G. Gallagher, Samuel E. Lux 560

16. Pyruvate Kinase Deficiency and Disorders of Glycolysis / William C. Mentzer, Jr. 685

17. Glucose-6-Phosphate Dehydrogenase Deficiency and Hemolytic Anemia / Lucio Luzzatto 721

VI. Disorders of Hemoglobin 743

18. Hemoglobins: Normal and Abnormal / Ronald L. Nagel 745

19. Sickle Cell Disease / George J. Dover, Orah S. Platt 790

20. The Thalassemias / Stuart H. Orkin, David G. Nathan 842

VII. The Phagocyte System 921

21. The Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function / Mary C. Dinauer 923

VIII. The Immune System 1011

22. Cell-Mediated and Humoral Immunity and the Regulation of Immune Responses / Barbara E. Bierer 1013

23. Primary Immunodeficiency Diseases / Francisco A. Bonilla, Raif S. Geha 1043

IX. Oncology 1079

24. Epidemiology of Leukemia in Childhood / Smita Bhatia, Leslie L. Robinson 1081

25. Chromosomal Abnormalities in Childhood Hematologic Malignant Disease / Harold J. Olney, Alessandro Gozzetti, Janet D. Rowley 1101

26. Acute Lymphoblastic Leukemia / Lewis B. Silverman, Stephen E. Sallan 1135

27. Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease in Children / Carolyn Bennett, Karl Hsu, A. Thomas Look 1167

28. Acute Leukemia in Infants / Gregory H. Reaman 1210

29. The Molecular Basis of Hematologic Malignancy / Todd R. Golub 1219

30. Minimal Residual Leukemia / John G. Gribben 1259

31. Pharmacology of Antineoplastic Agents and Multidrug Resistance / Stacey L. Berg, David G. Poplack 1274

32. Cell, Cytokine, Monoclonal Antibody, and Gene Therapy / Paul M. Sondel, Kenneth B. DeSantes 1307

33. The Lymphomas and Lymphadenopathy / Michael P. Link, Sarah S. Donaldson 1333

34. Lymphohistiocytic Disorders / John L. Sullivan, Bruce A. Woda 1375

X. Storage Diseases 1397

35. Storage Diseases of the Reticuloendothelial System / Edwin H. Kolodny, Gustavo Charria-Ortiz 1399

XI. Hemostasis 1455

36. Blood Platelets and the Vessel Wall / Robert I. Handin 1457

37. Blood Coagulation / Charles T. Esmon 1475

38. The Molecular Basis of Fibrinolysis / Katherine Amberson Hajjar 1497

39. Clinical and Laboratory Approach to the Patient with Bleeding / Jeanne M. Lusher 1515

40. Inherited Platelet Disorders / Mortimer Poncz 1527

41. Hemophilia and von Willebrand Disease / Robert R. Montgomery, Joan Cox Gill, J. Paul Scott 1547

42. Rare Hereditary Coagulation Factor Abnormalities / Kenneth A. Bauer 1577

43. Inherited Disorders of Thrombosis and Fibrinolysis / Kenneth A. Bauer 1583

44. Acquired Platelet Defects / David B. Wilson 1597

45. Acquired Disorders of Hemostasis / Paul Monagle, Maureen Andrew 1631

XII. Supportive Therapy 1669

46. Psychologic Aspects of Leukemia and Hematologic Disorders / Elissa Jelalian, Julie Boergers, Anthony Spirito, Barbara Sourkes 1671

47. Infectious Complications in Children with Hematologic Disorders / Andrew Y. Koh, Philip A. Pizzo 1684

48. Transfusion Medicine / Steven R. Sloan, Richard J. Benjamin, David F. Friedman, Iain J. Webb, Leslie Silberstein 1709

XIII. Hematologic Manifestations of Systemic Diseases 1757

49. Hematologic Manifestations of Systemic Diseases / R. Alan, B. Ezekowitz, James A. Stockman III 1759

50. Hematologic Manifestations of Systemic Diseases in Children of the Developing World / David Weatherall, Dominic Kwiatkowski 1810

Reference Values in Early Childhood / Carlo Brugnara 1835.

Notes:

Includes bibliographical references and index.

ISBN:

0721693172

OCLC:

50155290