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50 years of DNA / edited by Julie Clayton and Carina Dennis ; foreword by Philip Campbell.
Veterinary: Atwood Library (Campus) QP624 .A15 2003
Available
- Format:
- Book
- Language:
- English
- Subjects (All):
- DNA--History--Popular works.
- DNA.
- History.
- Genre:
- Popular works.
- Physical Description:
- 144 pages : illustrations (some color) ; 29 cm
- Other Title:
- Fifty years of DNA
- 50 years of D.N.A.
- Place of Publication:
- Houndmills, Basingstoke, Hampshire ; New York : Palgrave Macmillan, 2003.
- Summary:
- Published in association with Nature--the authoritative book on the landmark discovery of the double helix. Crick and Watson's discovery of the structure of DNA fifty years ago marked one of the great turning points in the history of science. Biology, immunology, medicine, and genetics have all been radically transformed in the succeeding half-century, and the double helix has become an icon of our times. Published in association with Nature, this fascinating exploration of a scientific phenomenon provides an engaging account of the background and context for the discovery, its significance, and its enduring afterlife. A series of essays by leading scientists, historians, and commentators offers unique perspectives on DNA and its impact on modern science and society.
- Contents:
- 1 On the shoulders of giants 7
- Here's looking at you 7
- The struggle for life 7
- Blending out, genes in 8
- The chromosome trail 9
- Recipe for DNA 10
- Proteins versus DNA 10
- The ascent of DNA 11
- 2 The triumph of 1953 12
- The players 12
- The crucial steps 16
- 1951 16
- Seeing is believing 17
- 1952 19
- 1953 20
- The aftermath 24
- Mad hatters at the DNA tea party 25
- 3 The golden years of molecular biology 26
- Timeline: Life begins in the 1950s 26
- Interview with Walter Gilbert 28
- Timeline: Code breakers of the 1960s 28
- Timeline: The cut and paste of the 1970s 30
- A matter of life and death: Interview with Kary Mullis 31
- Timeline: Machines of the 1980s 32
- Craig Venter 34
- Timeline: Genomes of the 1990s 34
- 4 Where are they now? 36
- Max Perutz 36
- James Watson 37
- Interview with James Watson 39
- Francis Crick 42
- Rosalind Franklin 44
- Maurice Wilkins 44
- Aaron Klug 45
- Interview with Maurice Wilkins 46
- Linus Pauling 47
- 5 Crystal gazing 49
- Crude preparations 49
- How to grow a crystal 49
- X-ray vision 50
- Drug design 52
- 6 Genomes galore 54
- Celebration time 54
- What makes humans so complex? 54
- Ancient relics 56
- Sea of data 56
- Our family and other animals 56
- More than just trophies 57
- 7 Tracing human origins 58
- Out of Africa 58
- Story makers 58
- Male and female lines of inquiry 58
- Closer to home 60
- What happened to the menfolk? 62
- Danger of misinterpretation 62
- 8 Gene detectives 64
- Family ties 64
- Choosing babies 64
- The 'fat' epidemic 65
- Fat mice, thin kids 66
- War on cancer 67
- Smart weapons 68
- Bug busters 68
- 9 DNA in culture 69
- DNA in popular fiction / Christopher Surridge 70
- DNA as an art form / Steve Nadis 72
- DNA in education 74
- 10 The genie is out 75
- Year of the clone? 75
- Fear of discrimination 77
- Control freaks 78
- Nature essays
- Introduction: The eternal molecule / Carina Dennis, Philip Campbell 82
- Facsimile papers from Nature, 25 April 1953
- A structure for deoxyribose nucleic acid (Nature, 171: 737-8, 1953) / J. D. Watson, F. H. C. Crick 83
- Molecular structure of deoxypentose nucleic acids (Nature, 171: 738-40, 1953) / M. H. F. Wilkins, A. R. Stokes, H. R. Wilson 84
- Molecular configuration in sodium thymonucleate (Nature, 171: 740-1, 1953) / Rosalind E. Franklin, R. G. Gosling 86
- Historical perspectives
- Quiet debut for the double helix / Robert Olby 88
- Discovering genes are made of DNA / Maclyn McCarty 92
- The double helix and the 'wronged heroine' / Brenda Maddox 93
- DNA in medicine and society
- The mosaic that is our genome / Svante Paabo 95
- Nature, nurture and human disease / Aravinda Chakravarti, Peter Little 98
- The double helix in clinical practice / John I. Bell 100
- The Mona Lisa of modern science / Martin Kemp 102
- DNA: the biological molecule
- Portrait of a molecule / Philip Ball 107
- Ten years of tension: single-molecule DNA mechanics / Carlos Bustamante, Zev Bryant, Steven B. Smith 109
- DNA in a material world / Nadrian C. Seeman 113
- DNA replication and recombination / Bruce Alberts 117
- DNA damage and repair / Errol C. Friedberg 122
- The double helix and immunology / Gustav J. V. Nossal 126
- The digital code of DNA / Leroy Hood, David Galas 130
- Controlling the double helix / Gary Felsenfeld, Mark Groudine 134
- Gene speak 140.
- Notes:
- "Nature."
- Includes bibliographical references (page 141) and index.
- Local Notes:
- Acquired for the Penn Libraries with assistance from the Edward Potts Cheyney Memorial Fund.
- ISBN:
- 1403914796
- OCLC:
- 51623877
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