Membrane lipid signaling in aging and age-related disease / volume editor, Mark P. Mattson.

Format:

Book

Contributor:

Mattson, Mark P.

Series:

Advances in cell aging and gerontology 1566-3124 ; v. 12.

Advances in cell aging and gerontology, 1566-3124 ; v. 12

Language:

English

Subjects (All):

Membrane lipids--Physiological effect.

Membrane lipids.

Membrane lipids--Pathophysiology.

Cellular signal transduction.

Aging--Molecular aspects.

Aging.

Nervous system--Degeneration--Molecular aspects.

Nervous system.

Membrane Lipids--physiology.

Signal Transduction.

Aging--physiology.

Nervous system--Degeneration.

Physiology, Pathological.

Medical Subjects:

Membrane Lipids--physiology.

Signal Transduction.

Aging--physiology.

Physical Description:

ix, 225 pages : illustrations (some color) ; 25 cm.

Edition:

First edition.

Place of Publication:

Amsterdam ; Boston : Elsevier, 2003.

Summary:

The plasma membrane of cells throughout the body lies at the interface between the inner workings of the cell and the extracellular environment. In response to stimulation by various growth factors, cytokines and neurotransmitters as well as in response to stressors, such as oxygen radicals, different membrane lipids are modified either enzymatically or non-enzymatically. The products of membrane phospholipids, sphingolipids and other lipids are released within the cell and mediate physiological responses to the stimuli. In this volume of Advances in Cell Aging and Gerontology leading experts in the field of membrane lipid signalling in relation to aging and age-related disease provide a comprehensive overview of the impact of aging on membrane lipid signalling and the role of such alterations in the aging process and age-related dysfunction and disease in various cell types throughout the body. It is increasingly recognized that alterations in membrane lipid metabolism contribute to the pathogenesis of diseases such as atherosclerosis, cancers and neurodegenerative disorders. This book presents cutting-edge information on specific membrane lipids including cholesterol, inositol phospholipids, sphingolipids, ceramides and eicosanoids and their roles in cellular dysfunction and degeneration in aging and diseases of aging. Particularly interesting is the fact that membrane lipid composition can be modified by dietary lipid intake and other dietary modifications suggesting a role for membrane lipid responses in dietary modification of aging and age-related disease. This book will be of great interest to graduate students, postdoctoral scientists, and senior investigators in academic, government and industry labs who study aging and age-related diseases. Experts on membrane lipid signalling who also may have an emerging interest in aging and diseases of aging will find this book full of valuable information to be used in developing their research programs.

Contents:

Chapter 1 Overview: Spatial Control of Signal Transduction by Caveolae and Lipid Rafts / Christopher J. Fielding 1

Chapter 2 Overview: Membrane Lipid Peroxidation / Kathleen S. Montine, Joseph F. Quinn, Thomas J. Montine 11

Chapter 3 Regulation of Invertebrate Longevity by Inositol Phosphate Signaling / Catherine A. Wolkow 27

Chapter 4 Ceramide-Driven Stress Signals in Cancer and Aging / Peter P. Ruvolo, Charlene R. Johnson, W. David Jarvis 47

Chapter 5 Sphingolipid Metabolism and Signaling in Atherosclerosis / Subroto Chatterjee, Sergio F. Martin 71

Chapter 6 Sphingomyelin and Ceramide in Brain Aging, Neuronal Plasticity and Neurodegenerative Disorders / Mark P. Mattson, Roy G. Cutler 97

Chapter 7 The Eicosanoid Pathway and Brain Aging / Hari Manev, Tolga Uz 117

Chapter 8 Cellular Cholesterol, Membrane Signaling, and Disease / John P. Incardona 137

Chapter 9 Cholesterol, [beta]-amylod, and Alzheimer's Disease / Miguel A. Pappolla, Suzana Petanceska, Lawrence Refolo, Nicolas G. Bazan 163

Chapter 10 Phospholipase A[subscript 2] in the Pathogenesis of Cardiovascular Disease / Eva Hurt-Camejo, Peter Sartipy, Helena Peilot, Birgitta Rosengren, Olov Wiklund, German Camejo 177

Chapter 11 Retinal Docosahexaenoic Acid, Age-Related Diseases, and Glaucoma / Nicolas G. Bazan, Elena B. Rodriguez de Turco 205.

Notes:

Includes bibliographical references.

ISBN:

0444512977

OCLC:

51553184