Modification of radiation response : cytokines, growth factors, and other biological targets / C. Nieder, L. Milas, K.K. Ang, eds. ; with contributions by N. Andratschke ... [and others] ; foreword by L.W. Brady, H.-P. Heilmann, and M. Molls.

Format:

Book

Contributor:

Nieder, C. (Carsten), 1964-

Milas, Luka.

Ang, K. K. (K. Kian)

Series:

Medical radiology (Series)

Medical radiology

Language:

English

Subjects (All):

Cancer--Radiotherapy.

Cancer.

Cancer--Adjuvant treatment.

Radiation--Physiological effect.

Radiation.

Neoplasms--radiotherapy.

Cytokines.

Growth Substances.

Radiation-Sensitizing Agents--therapeutic use.

Medical Subjects:

Neoplasms--radiotherapy.

Cytokines.

Growth Substances.

Radiation-Sensitizing Agents--therapeutic use.

Physical Description:

281 pages : illustrations (some color) ; 28 cm.

Place of Publication:

Berlin ; New York : Springer, 2003.

Summary:

This book describes and summarizes the radiation responses of both normal and neoplastic tissues with a focus on rational strategies for the modification of these responses. Emerging data from molecular oncology and radiobiology that form the basis for a better understanding of radiation-induced reactions and key features of malignant growth are reviewed. Special emphasis is placed on the role of cytokines and growth factors as well as signal transduction pathways. A unique feature of the book is that it has been written in close collaboration by basic scientists, radiobiologists, and radiation oncologists. Therefore it covers not only general principles of radiation-induced reactions but also a large number of preclinical and clinical data that will guide the reader through this complex and dynamic field and will provide valuable information for the development of further research projects. Many of the data reviewed in this book form a sound basis for further improvement of state-of-the art radiation therapy by integrating biological concepts into the process of treatment planning and delivery.

Contents:

Part I Normal Tissues 1

1 The Potentional Role of Signaling Proteins in the Acceleration of Repopulating Normal and Malignant Tissues / Klaus-Rudiger Trott 3

2 Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues / Hans-Peter Rodemann 15

3 Pathogenetic Mechanisms of Lung Fibrosis / Wolfgang Dorr, Thomas Herrmann 29

4 Strategies for Modification of the Radiation Response of the Lung / C. Nieder 37

5 Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs / Martin Hauer-Jensen, Junru Wang, James W. Denham 49

6 Mechanisms and Modification of the Radiation Response of the Central Nervous System / Carsten Nieder, Nicolaus Andratschke, K. Kian Ang 73

7 Hematopoietic Tissue I: Response Modification by Erythropoietin / Jurgen Dunst 89

8 Hematopoietic Tissue II: Role of Colony-Stimulating Factors / Carsten Nieder, Branislav Jeremic, Thomas Light, Frank B. Zimmermann 103

9 Oral Mucosa: Response Modification by Keratinocyte Growth Factor / Wolfgang Dorr 113

Part II Malignancies 123

10 Role of Growth Factors in Tumor Growth and Progression of Gynecological Tumors / Jennifer F. De Los Santos, James M. Bonner, Shannon Goddard, Anthony W. Fyles 125

11 Growth Factor Expression in Central Nervous System Tumours / Carsten Nieder, Nicolaus Andratschke, Juergen Schlegel 139

12 Role of Growth Factors and Biological Response Modifiers in Lung, Head and Neck and Gastrointestinal Tumors / G. Stuben, Martin Stuschke 147

13 Role of Signaling Pathway Modification / Oliver Riesterer, Martin Pruschy, Stephan Bodis 157

14 Anti-VEGF Strategies in Combination with Radiotherapy / Daniel Zips, Michael Baumann 179

15 Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy / Luka Milas, Z. Fan, Kathy A. Mason, K. Kian Ang 189

16 Enhancement of the Radiation Response with Interleukins and Interferons / Frank Lohr, Carsten Herskind, Jens Lohr, Frederik Wenz, Chuan-Yuan Li 205

17 Enhancement of Radiation Response with TNF/TRAIL / Anupama Munshi, Raymond E. Meyn 227

18 Role of Cyclooxygenase-2 (COX-2) and its Inhibition in Tumor Biology and Radiotherapy / Luka Milas, Kathy Mason, Zhongxing Liao, Uma Raju, Mira Milas, Amir Husain, K. Kian Ang 241

19 Ras Signaling and Its Inhibition with Farnesyltransferase Inhibitors: Effects on Radiation Resistance and the Tumor Microenvironment / Eric J. Bernhard, Anjali K. Gupta, Stephen M. Hahn, Ruth J. Muschel, W. Gillies McKenna 259.

Notes:

Includes bibliographical references and index.

ISBN:

3540422315

OCLC:

50560781