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Signal transduction in cancer / edited by David A. Frank.
Holman Biotech Commons RC268.5 .S546 2003
Available
- Format:
- Book
- Series:
- Cancer treatment and research ; v. 115.
- Cancer treatment and research ; v. 115
- Language:
- English
- Subjects (All):
- Carcinogenesis.
- Cancer--Molecular aspects.
- Cancer.
- Cellular signal transduction.
- Neoplasms--therapy.
- Neoplasms--physiopathology.
- Signal Transduction--physiology.
- Medical Subjects:
- Neoplasms--therapy.
- Neoplasms--physiopathology.
- Signal Transduction--physiology.
- Physical Description:
- 354 pages : illustrations ; 24 cm.
- Place of Publication:
- Boston : Kluwer Academic Publishers, 2003.
- Summary:
- One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
- Contents:
- Receptors
- 1. Growth, Survival and Migration: The Trk to Cancer / Joshua B. Rubin, Rosalind A. Segal 1
- 2. The role of growth factor signaling in malignancy / Roy S. Herbst, Amir Onn, John Mendelsohn 19
- 3. TGF-[beta] Signaling Alterations in Cancer / Yansong Bian, Virginia Kaklamani, Jennifer Reich, Boris Pasche 73
- 4. Notch in Malignancy / Douglas W. Ball, Steven D. Leach 95
- Intracellular Pathways
- 5. cAMP Signaling in Cancer Genesis and Treatment / Yoon S. Cho-Chung 123
- 6. PI3K/PTEN/Akt Pathway: A Critical Mediator of
- 7. Oncogenic Signaling / Juan Paez, William R. Sellers 145
- 8. Wnt signaling in Human Cancer / Patrice J. Morin, Ashani T. Weeraratna 169
- 9. Ras Signaling, Deregulation of Gene Expression and Oncogenesis / Aylin S. Ulku, Channing J. Der 189
- 9. Role of the RB Tumor Suppressor in Cancer / Lili Yamasaki 209
- Transcription Factors
- 10. The Rel/NF-[kappa]B/I[kappa]B Signal Transduction Pathway and Cancer / Thomas D. Gilmore 241
- 11. STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies / David A. Frank 267
- 12. Steroid Hormone Receptor Signaling in Cancer / Shinta Cheng, Steven P. Balk 293
- Cell Death Pathways
- 13. Cell Death Signaling in Malignancy / Timothy F. Burns, Wafik S. El-Deiry 319
- 14. Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies / David K. Perry, Richard N. Kolesnick 345.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 1402073402
- OCLC:
- 50803753
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