Oxygen sensing : responses and adaptation to hypoxia / edited by Sukhamay Lahiri, Gregg L. Semenza, Nanduri R. Prabhakar.

Format:

Book

Contributor:

Lahiri, Sukhamay.

Semenza, Gregg L.

Prabhakar, Nanduri R.

Series:

Lung biology in health and disease ; v. 175.

Lung biology in health and disease ; v. 175

Language:

English

Subjects (All):

Oxygen--physiology.

Adaptation, Physiological.

Cell Hypoxia.

Chemoreceptors--physiology.

Carotid Body--physiology.

Respiratory Physiological Phenomena.

Medical Subjects:

Oxygen--physiology.

Adaptation, Physiological.

Cell Hypoxia.

Chemoreceptors--physiology.

Carotid Body--physiology.

Respiratory Physiological Phenomena.

Physical Description:

xxx, 775 pages : illustrations ; 24 cm.

Other Title:

Responses and adaptation to hypoxia

Place of Publication:

New York : Marcel Dekker, [2003]

Summary:

Compiling breakthrough studies from more than 100 specialists in the field, this reference delineates the molecular basis of oxygen homeostasis by detailing mechanisms underlying the regulation of gene expression and electrophysiological responses to acute and chronic hypoxia through the exploration and manipulation of sensory transduction and transmission sites, and carotid body adaptation, structure, and function. Oxygen Sensing examines O[subscript 2] sensing systems in bacteria and Archaea...demonstrates interrelationships among cell proliferation, energy metabolism, oxygen homeostasis, redox states, signal transduction, and gene expression in humans and other organisms...details the role of excitatory and inhibitory neurotransmitters in sensory signaling...describes the effect of hypoxia on carotid body structure and function...and considers the effect of alterations in oxygen homeostasis on the pathophysiology of cardiac ischemia, cancer, stroke, and chronic lung disease.

Contents:

Part 1 Genomics of Oxygen Sensing / Gregg L. Semenza 1

1. Biochemistry and Physiological Importance of Heme Proteins as Oxygen Sensors / Marie-Alda Gilles-Gonzalez 7

2. A Role for the Mitochondrion and Reactive Oxygen Species in Oxygen Sensing and Adaptation to Hypoxia in Yeast / Robert O. Poyton, Reinhard P. Dirmeier, Kristin M. O'Brien, Erick Spears 23

3. Regulation of HIF-1 by Oxygen: The Role of Prolyl Hydroxylase and the VHL Tumor Suppressor / Patrick H. Maxwell, Peter J. Ratcliffe 47

4. Oxygen- or Redox-Dependent Regulation: The Role of Hydrogen Peroxide in the Regulation of Erythropoietin Gene Expression / Joachim Fandrey 67

5. Structure and Regulation of the Mouse Hypoxia-Inducible Factor-1[alpha] Gene / Roland H. Wenger 83

6. Hypoxia-Inducible Factor-1: More Than a Hypoxia-Inducible Transcription Factor / Thomas Hellwig-Burgel, Daniel Phillip Stiehl, Wolfgang Jelkmann 95

7. Brain Microvascular and Metabolic Adaptation to Prolonged Mild Hypoxia / Faton H. Agani, Juan Carlos Chavez, Paola Pichiule, Joseph C. LaManna 109

8. Molecular Adaptation to Hypoxia / Karen A. Seta, Yong Yuan, Zachary Spicer, Gang Lu, David E. Millhorn 123

9. Regulation of Tyrosine Hydroxylase Gene Expression by Hypoxia in Neuroendocrine Cells / Maria F. Czyzyk-Krzeska, Phillip O. Schnell, Amy L. Bauer, Justin B. Striet, James A. Nash, Anna V. Kuznetsova, Anna S. Hui 153

10. Genome-wide Computational Screen for Candidate HIF Target Genes in Drosophila melanogaster and Caenorhabditis elegans / Thomas A. Gorr, Pavel Hradecky, Joshua D. Cahn, H. Franklin Bunn 175

Part 2 Oxygen Sensing in the Carotid Body, and Other Cells, Organs, and Organelles / Sukhamay Lahiri, Nanduri R. Prabhakar

11. Fetal Adaptations to Hypoxia / James P. Newman, Mark A. Hanson, Lucy R. Green 209

12. Perinatal Transition of Oxygen Sensing in the Peripheral Chemoreceptors / Jean-Christophe Roux, Julie Peyronnet, Hugo Lagercrantz 235

13. Postnatal Maturation of the Carotid Chemoreceptor O[subscript 2] Sensitivity at the Cellular Level / John L. Carroll 251

14. Maturation of Chemoreceptor O[subscript 2] and CO[subscript 2] Sensitivity / Prem Kumar 273

15. Further Evidence That Oxygen Sensing in the Carotid Body Involves Iron and Heme Proteins / Sukhamay Lahiri, Arijit Roy, Anil Mokashi, Peter A. Daudu, Jinquing Li, Santhosh M. Baby, Donald G. Buerk 289

16. O[subscript 2]-Sensitive K[superscript +] Channels Controlling Cell Excitability / Chris Peers, Anthony Lewis, Leigh D. Plant, Hugh A. Pearson, Paul J. Kemp 299

17. Carotid Body Thin Slices: New Answers for Old Questions / Jose Lopez-Barneo, Ricardo Pardal 315

18. Electric and Dye Coupling Between Rat Carotid Body Cells and Between These Cells and Carotid Nerve Endings / Carlos Eyzaguirre, Rugang Jiang, Veronica Abudara 331

19. From Oxygen Sensing to Chemosensory Activity: The Mediator Role of Glomus Cells / Patricio Zapata 353

20. Excitation of Glomus Cells: Interaction Between Voltage-Gated K[superscript +] Channels and Cholinergic Receptors / Machiko Shirahata, Tomoko Higashi, Serabi Hirasawa, Shigeki Yamaguchi, Robert S. Fitzgerald, Boris Lande 365

21. Some Neurotransmitter Relationships in the Carotid Body's Response to Hypoxia / Robert S. Fitzgerald, Hay-Yan Wang, Serabi Hirasawa, Machiko Shirahata 381

22. Effects of Nitric Oxide on Carotid Body Oxygen Consumption at Low PO[subscript 2] / Donald G. Buerk, Sukhamay Lahiri 395

23. Nitric Oxide and Carotid Body Chemoreception: Multiple Target Sites / Rodrigo Iturriaga, Julio Alcayaga 409

24. Multiple Roles of Neurotransmitters in the Carotid Body: Involvement in Sensory Transmission and Adaptation to Hypoxia / Ganesh K. Kumar, Jeffery L. Overholt, Nanduri R. Prabhakar 421

25. Mechanisms of Morphological and Functional Plasticity in the Chronically Hypoxic Carotid Body / Bruce Dinger, Liang He, Jia Chen, L. J. Stensaas, Salvatore J. Fidone 439

26. Neurochemical Processes Involved in Acclimatization to Long-Term Hypoxia / Vincent Joseph, Jean-Marc Pequignot 467

27. Biology of Reactive Oxygen Species: Their Role in Oxygen Chemoreception in the Carotid Body / Constancio Gonzalez, Maria Teresa Agapito, Asuncion Rocher, Gloria Sanz Alfayate, Ana Obeso 489

28. Optical Analysis of the Oxygen-Sensing Signal Pathway / Helmut Acker, Utta Berchner-Pfannschmidt, Christoph Wotzlaw, Christine Huckstorf, Tino Streller 507

29. Mitochondria as Vascular Oxygen Sensors: The Redox Hypothesis of Vascular O[subscript 2] Sensing / Zlatko I. Pozeg, Bernard Thebaud, Benjamin D. Tyrrell, Evangelos D. Michelakis, Stephen L. Archer 523

30. Roles for NAD(P)H Oxidases as Vascular Oxygen Sensors and Their Influence on Oxidant-Regulated Signaling Mechanisms / Michael S. Wolin, Sachin A. Gupte, Richard A. Oeckler 553

31. Oxygen Sensing in Pulmonary Neuroepithelial Bodies and Related Tumor Cell Model / Ernest Cutz, Xiao Wen Fu, Herman Yeger, Chris Peers, Paul J. Kemp 567

32. Oxygen Sensing by Neonatal Adrenal Chromaffin Cells: A Role for Mitochondria? / Colin A. Nurse, Adele Jackson, Ian M. Fearon, Roger J. Thompson 603

33. O[subscript 2] Sensing in Neurons: Evidence and Requirement for a Multitude of Sensors / Gabriel G. Haddad 619

34. Oxygen Sensitivity of Central Cardiorespiratory Regions / Judith A. Neubauer, Jagadeeshan Sunderram, Nicola Ritucci, Dominic D'Agostino 633

35. Oxygen Sensing by the Brainstem in Respiratory Control / Irene C. Solomon, Norman H. Edelman 651

36. Petrosal Ganglion Responses In Vitro: From Entire Ganglion to Single Cell / Julio Alcayaga, Rodrigo Varas, Rodrigo Iturriaga 671

37. Comparative Aspects of O[subscript 2] Chemoreception: Anatomy, Physiology, and Environmental Adaptations / Mark L. Burleson, William K. Milsom 685.

Notes:

Includes index.

Includes bibliographical references.

ISBN:

0824709608

OCLC:

52157029