Hormones, genes, and cancer / [edited by] Brian E. Henderson, Bruce Ponder, Ronald K. Ross.

Format:

Book

Contributor:

Henderson, Brian E.

Ponder, B. A. J. (Bruce A. J.), 1944-

Ross, Ronald K. (Ronald Keith)

Language:

English

Subjects (All):

Cancer--Endocrine aspects.

Cancer.

Hormones--Carcinogenicity.

Hormones.

Generative organs--Cancer--Molecular aspects.

Generative organs.

Generative organs--Cancer--Chemoprevention.

Neoplasms--etiology.

Genes--physiology.

Hormones--physiology.

Medical Subjects:

Neoplasms--etiology.

Genes--physiology.

Hormones--physiology.

Physical Description:

xiii, 450 pages, 4 unnumbered pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Oxford ; New York : Oxford University Press, 2003.

Summary:

Hormonal carcinogenesis is an important and controversial area of current research. In addition to accelerating existing cancers, can hormones play the role of primary carcinogens? How do genetic factors influence hormone-related cancer risk? Hormones, Genes, and Cancer addresses these questions. Over the past few decades, cancer research has focused on external environmental causes (e.g., tobacco smoke, viruses, asbestos). With the advent of new genetic sequencing techniques, we are just now beginning to understand how the body's internal environment (i.e., the hormones and growth factors that determine normal development) influences cancer etiology and prevention. From molecular insights to clinical analyses, this volume provides state-of-the-art information on the complex interactions between hormones and genes and cancer. The epidemiology and molecular endocrinology of prostate, breast, uterine, ovarian, and testicular cancer are detailed in this timely treatise.

Contents:

2. Biosynthesis, Transport, and Metabolism of Steroid Hormones / Frank Z. Stanczyk, Philip Bretsky 12

3. The Nuclear Receptor Superfamily / John M. Rosenfeld, Hung-ying Kao, Ronald M. Evans 38

4. Genomic Approaches to the Genetics of Hormone-Responsive Cancer / Joel N. Hirschhorn, Celeste Leigh Pearce, David Altshuler 99

5. Breast Cancer: Epidemiology and Molecular Endocrinology / Heather Spencer Feigelson 120

6. The Impact of Exogenous Hormone Use on Breast Cancer Risk / Gillian K. Reeves, Emily Banks, Timothy J.A. Key 139

7. An Overview of Genetic Predisposition and the Search for Predisposing Genes for Breast Cancer / Bruce Ponder 157

8. Estrogen Biosynthesis Genes: P-450 Aromatase / Colin D. Clyne, Evan R. Simpson 169

9. Estrogen Metabolism Genes: HSD17B1 and HSD17B2 / Hellevi Peltoketo, Veli Isomaa, Debashis Ghosh, Pirkko Vihko 181

10. Breast Cancer: Intervention in BRCA1 and BRCA2 Families / Frances V. Elmslie, Rosalind A. Eeles 199

11. Implications of Hormones and Hormonal Risk Factors on Screening Strategies / Giske Ursin 210

12. Hormonal Chemoprevention with Tamoxifen and Selective Estrogen Receptor Modulators / David J. Bentrem, V. Craig Jordan 218

13. Other Hormonal Prevention Strategies / Darcy V. Spicer, Malcolm C. Pike 248

14. Progression from Hormone-Dependent to Hormone-Independent Breast Cancer / Isabell A. Schmitt, Milana Dolezal, Michael F. Press 255

15. Prostate Cancer: Epidemiology and Molecular Endocrinology / Ronald K. Ross, Nick M. Makridakis, Juergen K.V. Reichardt 273

16. Androgen Receptor Signaling in Prostate Cancer / Wayne D. Tilley, Grant Buchanan, Gerhard A. Coetzee 288

17. Hereditary Prostate Cancer: The Search for Major Genes and the Role of Genes Involved in Androgen Action / Bao-Li Chang, Aubrey R. Turner, William B. Isaacs, Jianfeng Xu 316

18. Androgen-Independent Prostate Cancer Progression: Mechanistic Insights / George V. Thomas, Charles L. Sawyers 331

19. Hormonal Therapies for Prostate Cancer / David I. Quinn, Derek Raghavan 343

20. Endometrial Cancer: Epidemiology and Molecular Endocrinology / Linda S. Cook, Jennifer A. Doherty, Noel S. Weiss, Chu Chen 371

21. Ovarian Cancer: Epidemiology and Molecular Endocrinology / Alice S. Whittemore, Valerie McGuire 398

22. Testicular Cancer: Epidemiology and Molecular Endocrinology / Anthony J. Swerdlow 413.

Notes:

Includes bibliographical references and index.

ISBN:

0195135768

OCLC:

49895248