Targeted therapy for cancer / edited by Konstantinos N. Syrigos and Kevin J. Harrington.

Format:

Book

Contributor:

Syrigos, Konstantinos N.

Harrington, Kevin J., 1958-

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Immunospecificity.

Cancer--Molecular aspects.

Neoplasms--therapy.

Antibodies, Monoclonal.

Genetic Therapy.

Immunotherapy.

Medical Subjects:

Neoplasms--therapy.

Antibodies, Monoclonal.

Genetic Therapy.

Immunotherapy.

Physical Description:

xviii, 343 pages, 4 unnumbered pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Oxford ; New York : Oxford University Press, 2003.

Summary:

The quest for therapeutic specificity is implicit in all branches of medicine. In cancer treatment, where the therapeutic modality is a cytotoxic agent such as radiotherapy or chemotherapy, such specificity is of paramount importance. The growing realization that current therapeutic options are likely to yield no more than incremental improvements in outcome has fuelled the search for more active targeted approaches. Targeted Therapy for Cancer discusses the more archetypal systemic targeted therapies, such as those employing monoclonal antibodies or liposomes, but also includes strategies, such as photodynamic therapy and boron neutron capture therapy, that rely on direct physical targeting of disease. The explosion in our understanding of the molecular biology of cancer in recent years has led to the identification of a number of new potential therapeutic targets. These factors, combined with the likelihood that yet more valuable information will be gleaned from the Human Genome Project, mean that significant clinical activity in this arena is anticipated in the coming years, with the very real prospect that gene therapy approaches may find an established role in the standard treatment of some of the common cancers. Targeted Therapy for Cancer brings together the very latest research in this field from an international group of experts and will prove invaluable for molecular oncologists, cancer researchers and those involved with clinical trials, as well as providing a reference for oncologists who are beginning to use some of these therapies in everyday clinical practice.

Contents:

1 The history of targeted therapy for cancer / K.D. Bagshawe 3

2 Preclinical models for the study of targeted therapy / Gail Rowlinson-Busza 17

3 Monoclonal antibody targeting therapy: an overview / Roslyn J. Francis, Richard H.J. Begent 29

4 Antibody-directed enzyme prodrug therapy (ADEPT) / Konstantinos N. Syrigos, Kevin J. Harrington 47

5 Monoclonal antibody targeted radionuclide therapy / Surinder K. Batra, Apollina Goel, Gabriela Pavlinkova, David Colcher 57

6 Combined external beam radiotherapy and radioimmunotherapy / David Raben, Donald J. Buchsbaum 76

7 Genetic immunotherapy for cancer / Hardev S. Pandha 95

8 Targeting of cancer gene therapy / Kevin J. Harrington, Richard G. Vile 111

9 Targeted genetic prodrug activation therapy / Anne Rigg, Hardev S. Pandha 155

10 Antisense therapy as a targeted modality / Justin Waters, David Cunningham 162

11 Dendritic cells

targeting the antitumor immune response / Alan Melcher, Richard G. Vile, Andrew Bateman, Kevin J. Harrington 187

12 Cell carriers for cancer gene therapy: bridging the gap between targeted vectors and systemic delivery? / Rosa Maria Diaz, Heung Chong, Richard G. Vile 204

13 Liposomal targeting of cytotoxic drugs / Kevin J. Harrington, Konstantinos N. Syrigos 224

14 Targeting blood vessels in vivo by using phage display libraries / Claudia Vidal, Marina Cardo-Vila, Johanna Lahdenranta, Wadih Arap, Renata Pasqualini 250

15 Photodynamic therapy / Michael R. Hamblin 259

16 Boron neutron capture therapy: a chemically targeted radiation modality / Gerard M. Morris, Jeffrey A. Coderre 276

17 Cancer immunotherapy directed at growth factor receptors: the ErbB/HER network as a prototype / Michael Sela, Bilha Schecheter, Yosef Yarden 291

18 Targeting the metastatic process / Lloyd A. Culp, Wen-Chang Lin, Nanette R. Kleinman, Priit Kogerman, Raymond Judware, Carson J. Miller, Julianne L. Holleran 317.

Notes:

Includes bibliographical references and index.

ISBN:

0198508964

OCLC:

50055138