Biomedical aspects of drug targeting / editors, Vladimir Muzykantov, Vladimir Torchilin.

Format:

Book

Contributor:

Muzykantov, Vladimir.

Torchilin, V. P.

Language:

English

Subjects (All):

Drug targeting.

Drug Delivery Systems.

Medical Subjects:

Drug Delivery Systems.

Physical Description:

xv, 506 pages : illustrations ; 24 cm

Place of Publication:

Boston : Kluwer Academic Pub., [2002]

Summary:

Biomedical Aspects of Drug Targeting includes general principles of drug targeting, targeting in the cardiovascular system, tumor targeting, brain targeting, miscellaneous targeting and novel approaches for targeting (new horizons). It is designed in a course-like fashion: from more general and simple to more complex material. This framework will help even unfamiliar readers to learn new topics and navigate in the text. Although the book is aimed primarily at industrial and academic pharmacologists and drug discovery researchers, its design will make the book useful for advanced level graduate students. Biomedical Aspects of Drug Targeting focuses on ligand-mediated drug targeting strategies, with additional chapters on general aspects of drug delivery that are of paramount importance in drug targeting (biological barriers, stealth technologies). Included are topics on targeting of genetic materials important in the biomedical context of the ligand-mediated targeting.

Contents:

Section 1 General Principles of Drug Targeting

1 Strategies and Means for Drug Targeting: An Overview / Vladimir P. Torchilin 3

2 Biological Barriers for Drug Targeting / Vladimir R. Muzykantov 27

Section 2 Cardiovascular Targeting

3 Targeting the Pathological Myocardium / Ban-An Khaw 47

4 Targeting Atherosclerotic Plaques / Ban-An Khaw 69

5 Thrombus Targeting of Plasminogen Activators and Anticoagulants / Karlheinz Peter, Christoph Bode 85

6 Tissue-Specific Pharmacodelivery and Overcoming Key Cell Barriers in Vivo: Vascular Targeting of Calveolae / Lucy A. Carver, Jan E. Schnitzer 107

7 Targeting Pulmonary Endothelium / Vladimir R. Muzykantov 129

8 Targeting Inflammation / Jonathan R. Lindner, Alexander L. Klibanov, Klaus Ley 149

9 Intravascular Re-Targeting of Viral Vectors / Paul N. Reynolds, Sergei M. Danilov 173

Section 3 Tumor Targeting

10 Polymer-Drug Conjugates: Targeting Cancer / Ruth Duncan 193

11 Enhanced Permeability and Retention (Epr) Effect: Basis for Drug Targeting to Tumor / Hiroshi Maeda 211

12 Ligand-Directed Destruction of Tumor Vasculature / Sophia Ran, Michael Rosenblum, Philip E. Thorpe 229

13 Tumor Necrosis Treatment and Imaging of Solid Tumors / Alan L. Epstein, Leslie A. Khawli, Peisheng Hu 249

14 Targeted Apoptosis: Antibodies Linked to RNA Damaging Agents / Susanna M. Rybak, Michaela Arndt, Juergen Krauss, Dianne L. Newton, Bang K. Vu, Zhongyu Zhu 275

15 Immunotoxins and Antibody-Drug Conjugates for Cancer Treatment / Victor S. Goldmacher, Walter A. Blattler, John M. Lambert, Ravi V.J. Chari 291

Section 4 Targeting to Brain

16 Blood-Brain Barrier Transport and Drug Targeting to the Brain / Ken-ichi Hosoya, Sumio Ohtsuki, Tetsuya Terasaki 313

17 Ldl-Receptor Mediated Drug Targeting to Malignant Tumors in the Brain / Ranajoy Sarkar, David S. Halpern, Stephen K. Jacobs, D. Robert Lu 327

18 Targeting Brain Trauma and Stroke / Margaret A. Petty, Eng H. Lo 347

19 Targeting Drugs into the Central Nervous System / Laszlo Prokai 359

Section 5 Miscellaneous, New Horizons in Targeting

20 Strategies for Targeting Infection / John W. Babich 381

21 Anti-Hiv Immunotoxins / Seth H. Pincus, Hua Fang, Royce Wilkinson 403

22 Ligand-Mediated Gastrointestinal Targeting / John Woodley 419

23 Transmembrane Targeting of DNA with Membrane Active Peptides / Sabine Boeckle, Ernst Wagner, Manfred Ogris 441

24 Polymersomes: A New Platform for Drug Targeting / Dennis E. Discher, Peter Photos, Fariyal Ahmed, Ranganath Parthasrathy, Frank S. Bates 459

25 Targeting Mitochondria / Volkmar Weissig, Gerard D'Souza, Vladimir P. Torchilin 473.

Notes:

Includes bibliographical references and index.

ISBN:

1402072325

OCLC:

50606484