Inflammatory bowel disease : from bench to bedside / edited by Stephan R. Targan, Fergus Shanahan, Loren C. Karp.

Format:

Book

Contributor:

Targan, Stephan R.

Shanahan, Fergus.

Karp, Loren C.

Language:

English

Subjects (All):

Inflammatory bowel diseases.

Inflammatory Bowel Diseases.

Medical Subjects:

Inflammatory Bowel Diseases.

Physical Description:

xv, 903 pages : illustrations (some color) ; 29 cm

Edition:

Second edition.

Place of Publication:

Dordrecht ; Boston : Kluwer Academic Pub., 2003.

Summary:

This book is intended to be more than a comprehensive compilation of reviews by individual authors on different aspects of inflammatory bowel diseases. It is intended that the individual chapters be components of a coherent, albeit detailed, story of the local and systemic pathophysiology of intestinal inflammation, with a well-reasoned series of management strategies. Our goal was not only to produce a standard reference text, but also to present research advances and current concepts of etiopathogenesis in the context of what is already known of the clinicopathologic features of these disorders. Our vision was to have a book that would blend recent advances in the basic and clinical sciences as they relate to inflammatory bowel disease. It is our hope that that the book will illustrate the effectiveness of a team approach of basic scientists and clinician investigators in this field. The book will give the reader a glimpse of where the field is moving and an idea of likely research directions in the future. Of course, it is our personal wish that this book will stimulate ideas for future research.

Contents:

Section I The laboratory bench

1. Introduction: Inflammatory bowel diseases: from bench to bedside / Fergus Shanahan, Loren C. Karp, Stephan R. Targan 3

2. The changing faces of Crohn's disease and ulcerative colitis / Anders Ekbom 5

3. Genetics of inflammatory bowel disease / Kent D. Taylor, Jerome I. Rotter, Huiying Yang 21

4. Experimental mouse models of inflammatory bowel disease: new insights into pathogenic mechanisms / Charles O. Elson, Casey T. Weaver 67

5. The normal intestinal mucosa: a state of 'controlled inflammation' / Claudio Fiocchi 101

6. The lymphocyte-epithelial-bacterial interface / Robert Hershberg, Richard S. Blumberg 121

7. The mucosal inflammatory response. Cytokines and chemokines / Fabio Cominelli, Kristen O. Arseneau, Theresa T. Pizarro 147

8. Role of the microcirculation in chronic gut inflammation / Matthew B. Grisham, F. Stephen Laroux, D. Neil Granger 177

9. Remission, relapse, intestinal healing and repair / Michael N. Goke, Daniel Podolsky 197

10. Antibodies in the exploration of inflammatory bowel disease pathogenesis and disease stratification / Jonathan Braun, Offer Cohavy, Mark Eggena 211

11. Pathophysiology of inflammatory bowel disease: the effect of inflammation on intestinal function / Stephen M. Collins, Kenneth Croitoru 223

12. Systemic consequences of intestinal inflammation / Konstantinos A. Papadakis, Maria T. Abreu 235

Section II The bedside

13. Understanding symptoms and signs in inflammatory bowel disease / Cornelius C. Cronin, Fergus Shanahan 253

14. Clinical course and complications of ulcerative colitis and ulcerative proctitis / Remo Panaccione, Lloyd R. Sutherland 269

15. Clinical features and complications of Crohn's disease / William J. Tremaine 291

16. Mechanisms of systemic inflammation associated with intestinal injury / R. Balfour Sartor, Steven N. Lichtman 305

17. Pathology of inflammatory bowel diseases: a critical appraisal in diagnosis and management / Galen Cortina, Klaus Lewin 337

18. An endoscopic and histologic perspective of diagnosis: when, where, and what to do / Charles N. Bernstein, Robert H. Riddell 357

19. Radiologic (radiographic) and imaging features of ulcerative colitis and Crohn's disease / Edward Fitzgerald 371

20. New diagnostic approaches in inflammatory bowel disease / Lori Kam, Eric Vasiliauskas 409

21. Differential diagnosis of colitis / Sue C. Eng, Christina M. Surawicz 431

22. 'Disease management' in chronic medical conditions / David H. Alpers 457

23. Pharmacoeconomics and inflammatory bowel disease / Brian G. Feagan 471

24. Measuring quality of life in inflammatory bowel disease / E. Jan Irvine 481

25. Clinical pharmacology in inflammatory bowel disease: optimizing current medical therapy / Laurence J. Egan, William J. Sandborn 495

26. Multi-site therapeutic modalities for inflammatory bowel diseases - mechanisms of action / Gerhard Rogler 523

27. Targeted therapies for inflammatory bowel disease / Sander J.H. van Deventer 553

28. Role of antibiotics and probiotics in the management of inflammatory bowel disease / Philippe Marteau, Fergus Shanahan 573

29. Nutrition in inflammatory bowel disease / Gregg W.Van Citters, Henry C. Lin 587

30. Medical management of ulcerative colitis / William J. Sandborn 605

31. Surgical management of ulcerative colitis / Ian Lindsey, Neil J. McC Mortensen 631

32. Pouchitis: clinical characteristics and management / Uma Mahadevan, William J. Sandborn 643

33. Medical therapy for Crohn's disease / Stephen B. Hanauer, Themistocles Dassopoulos 659

34. Surgery for Crohn's disease / Robin S. McLeod 681

35. Postoperative prevention of recurrence of Crohn's disease / Filip Baert, Geert D'Haens, Paul Rutgeerts 697

36. The molecular pathology of inflammatory bowel disease-associated neoplasia and preneoplasia / Stephen Meltzer 711

37. Dysplasia in inflammatory bowel disease: clinical pathology and current surveillance methods / Catherine J. Streutker, Roger C. Haggitt, Robert H. Riddell 719

38. Hepatobiliary disorders / Sue Cullen, Roger Chapman 731

39. Articular and ocular complications of inflammatory bowel disease / Timothy R. Orchard, Derek P. Jewell 747

40. Cutaneous manifestations of inflammatory bowel disease / Scott W. Binder 757

41. Fertility and pregnancy in inflammatory bowel disease / William Connell 763

42. Special considerations in the diagnosis and management of inflammatory bowel disease in the pediatric age group / Ernest G. Seidman, Arlene Caplan 773

43. Microscopic colitis: collagenous and lymphocytic colitis / Diarmuid O'Donoghue, Kieran Sheahan 791

44. Colon ischemia / Seth E. Persky, Lawrence J. Brandt 799

45. Diversion colitis / Konrad H. Soergel 811

46. Pseudomembranous colitis and Clostridium difficile infection / Richard J. Farrell, Lorraine Kyne, Ciaran P. Kelly 823

47. Infectious colitis / Michael J.G. Farthing 845

48. Human immunodeficiency virus and inflammatory bowel disease / Charles Mel Wilcox 863

49. Bone metabolism and inflammatory bowel disease / Maria T. Abreu 875

Section III Back to the laboratory bench

50. Epilogue: Bench to bedside and back to bench / Stephan R. Targan, Loren C. Karp, Fergus Shanahan 887.

Notes:

Includes bibliographical references and index.

ISBN:

1402007132

OCLC:

50280118