Cardiac repolarization : bridging basic and clinical science / edited by Ihor Gussak ... [and others] ; foreword by Douglas P. Zipes.

Format:

Book

Contributor:

Gussak, Ihor.

Series:

Contemporary cardiology (Totowa, N.J.)

Contemporary cardiology

Language:

English

Subjects (All):

Heart--Electric properties.

Heart.

Electrocardiography.

Arrhythmia.

Arrhythmias, Cardiac--physiopathology.

Electrocardiography--methods.

Ventricular Function--physiology.

Medical Subjects:

Arrhythmias, Cardiac--physiopathology.

Electrocardiography--methods.

Ventricular Function--physiology.

Physical Description:

xvii, 548 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

The past decade has been an explosion of knowledge and radical changes in our understanding of ventricular repolarization as an integral part of the cardiac electrophysiologic matrix. Cardiac Repolarization: Bridging Basic and Clinical Science comprehensively reviews all the latest developments in cardiac electrophysiology, focusing on both clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions, among them early repolarization and short QT interval, Brugada syndrome, long QT syndrome, and sudden infant death syndrome. Chapters delineate objectives and key points, and include established and evidence-based knowledge, current perspectives, areas of controversy, and recommendations for future investigations. Comprehensive and clinically oriented, Cardiac Repolarization: Bridging Basic and Clinical Science surveys the major research discoveries that have recently transformed our understanding of cardiac electrophysiology and spells out in full detail their clinical implications for the diagnosis and treatment of patients with malignant electrical instability of the heart.

Contents:

Chapter 1. Ventricular Repolarization and the Identification of the Sudden Death Candidate: Hype or Hope? / Hein J. Wellens, Douglas P. Zipes 3

Chapter 2. Historical Milestones of Electrical Signal Recording and Analysis / Thorsten Lewalter, Berndt Luderitz 7

Part II. Basic Electrophysiology, Pharmacology, and Molecular Biology of Ventricular Repolarization / Edited by Charles Antzelevitch

Chapter 3. Physiology and Molecular Biology of Ion Channels Contributing to Ventricular Repolarization / Jeanne M. Nerbonne, Robert S. Kass 25

Chapter 4. Electrophysiology and Pharmacology of Ventricular Repolarization / Charles Antzelevitch, Andrew C. Zygmunt, Robert Dumaine 63

Chapter 5. How Do We Measure Repolarization Inside the Heart? / Charles Antzelevitch, Andrew C. Zygmunt, Jeffrey Fish, Guillermo Perez, Fabiana Scornik 91

Chapter 6. Contribution of Electrical Heterogeneity of Repolarization to the ECG / Charles Antzelevitch, Vladislav V. Nesterenko 111

Chapter 7. Electrical and Structural Remodeling of the Ventricular Myocardium in Disease / Antonis A. Armoundas, Gordon F. Tomaselli 127

Chapter 8. Ischemia-Related Changes in Repolarization / Andre G. Kleber, Michiel J. Janse 153

Chapter 9. The Long QT Syndrome: Molecular and Genetic Aspects / Carlo Napolitano, Silvia G. Priori 169

Chapter 10. Ion Channel Disease as a Cause of the Brugada Syndrome: Molecular and Genetic Aspects / Connie R. Bezzina, Arthur A. M. Wilde 187

Chapter 11. Cellular and Ionic Mechanisms Underlying Arrhythmogenesis / Charles Antzelevitch, Alexander Burashnikov, Jose M. Di Diego 201

Part III. Clinical Physiology and Pathophysiology of Ventricular Repolarization: Theory and Practice / Edited by Stephen C. Hammill, Edited by Win-Kuang Shen, Edited by Ihor Gussak

Chapter 12. Evaluation of Ventricular Repolarization: The Clinican's Perspective / Jan Nemec, Stephen C. Hammill, Win-Kuang Shen 255

Chapter 13. Human Cardiac Repolarization / Philip T. Sager 291

Chapter 14. QT Interval and Its Drug-Induced Prolongation / Wojciech Zareba, Arthur J. Moss 311

Chapter 15. Neuro-Mediated Repolarization Abnormalities / Philippe Coumel, Pierre Maison-Blanche 329

Chapter 16. The Electrophysiologic Matrix: Equilibrium and Arnsdorf's Paradox / Morton F. Arnsdorf 351

Chapter 17. Antiarrhythmic Drugs and Future Direction / Arshad Jahangir, Andre Terzic, Win-Kuang Shen 387

Part IV. Specific Electrocardiographic Phenomena and Clinical Syndromes of Ventricular Repolarization / Edited by Ihor Gussak, Edited by Charles Antzelevitch, Edited by Preben Bjerregaard

Chapter 18. ECG Phenomena of the Early Ventricular Repolarization: Early Repolarization Syndrome / Ihor Gussak, Charles Antzelevitch, Preben Bjerregaard 407

Chapter 19. The Brugada Syndrome / Pedro Brugada, Ramon Brugada, Charles Antzelevitch, Koonlawee Nademanee, Jeffrey Towbin, Josep Brugada 427

Chapter 20. Clinical Evaluation, Risk Stratification, and Management of Congenital Long QT Syndrome / Anant Khositseth, Michael J. Ackerman 447

Chapter 21. Prolonged Repolarization and Sudden Infant Death Syndrome / Peter J. Schwartz 481

Chapter 22. Short QT Interval: ECG Phenomenon and Clinical Syndrome / Ihor Gussak, Charles Antzelevitch, Daniel Goodman, Preben Bjerregaard 497

Chapter 23. T-Wave Alternans: Mechanisms, Relevance, and Clinical Implications / Etienne Pruvot, David S. Rosenbaum 507.

Notes:

Includes bibliographical references and index.

ISBN:

1588290697

OCLC:

50639264