Platelet glycoprotin IIb/IIIa inhibitors in cardiovascular disease / edited by A. Michael Lincoff.

Format:

Book

Contributor:

Lincoff, A. Michael.

Series:

Contemporary cardiology (Totowa, N.J.)

Contemporary cardiology

Language:

English

Subjects (All):

Coronary heart disease--Chemotherapy.

Coronary heart disease.

Coronary heart disease--Pathophysiology.

Platelet glycoprotein GPIIb-IIIa complex--Inhibitors--Therapeutic use--Testing.

Platelet glycoprotein GPIIb-IIIa complex.

Cardiovascular Diseases--drug therapy.

Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors.

Testing.

Medical Subjects:

Cardiovascular Diseases--drug therapy.

Platelet Glycoprotein GPIIb-IIIa Complex--antagonists & inhibitors.

Physical Description:

x, 476 pages : illustrations ; 26 cm.

Edition:

Second edition.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

A. Michael Lincoff takes advantage of critically important new knowledge arising from recent clinical trials to update and expand his acclaimed Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease. This substantially enhanced Second Edition contains new chapters on the role of GPIIb/IIIa blockade during acute coronary syndromes, on outcomes with chronic oral GPIIb/IIIa blockade following acute coronary syndromes, and on fibrinolytic therapy during acute myocardial infarctions. Additional enhancements include revised findings from the latest trials of GPIIb/IIIa inhibition during percutaneous coronary intervention, discussion of GPIIb/IIIa blockade with other platelet and thrombin inhibitors, and a review of the potential effects beyond inhibition of platelet aggregation. The book also explains the scientific basis of this therapy, evaluates its benefits and risks for patients, and summarizes detailed data from its various clinical trials. Comprehensive and definitive, Platelet Glycoprotein IIb/IIIa Inhibitors in Cardiovascular Disease, Second Edition offers physicians, cardiologists, emergency room doctors, and basic scientists a complete and authoritative review of the state-of-the-art in glycoprotein IIb/IIIa receptor inhibitor use today.

Contents:

1 Thrombosis in Acute Coronary Syndromes and Coronary Interventions / Thaddeus R. Tolleson, Robert A. Harrington 3

2 Platelet Adhesion / Edward F. Plow 23

3 Glycoprotein IIb/IIIa in Platelet Aggregation and Acute Arterial Thrombosis / Patrick Andre, David R. Phillips 39

4 Glycoprotein IIb/IIIa Antagonists: Development of Abciximab and Pharmacology of Abciximab, Tirofiban, and Eptifibatide / Barry S. Coller 73

Part II Glycoprotein IIb/IIIa Blockade During Coronary Intervention

5 Abciximab During Percutaneous Coronary Intervention: EPIC, EPILOG, and EPISTENT Trials / A. Michael Lincoff 105

6 Eptifibatide in Coronary Intervention: The IMPACT and ESPRIT Trials / Jean-Pierre Dery, J. Conor O'Shea, James E. Tcheng 125

7 Tirofiban in Interventional Cardiology: The RESTORE and TARGET Trials / Nicholas Valettas, Howard C. Herrmann 147

8 Overview of the Glycoprotein IIb/IIIa Interventional Trials / A. Michael Lincoff, Eric J. Topol 167

Part III Glycoprotein IIb/IIIa Blockade for Acute Ischemic Syndromes

9 The Use of Abciximab in Therapy-Resistant Unstable Angina: Clinical and Angiographic Results of the CAPTURE Pilot Trial and the CAPTURE Study / Marcel J. B. M. van den Brand, Maarten L. Simoons 203

10 Unstable Angina Trials: PARAGON, PURSUIT, PRISM, PRISM-PLUS, and GUSTO-IV / David J. Moliterno 233

11 Platelet Glycoprotein IIb/IIIa Inhibitors and an Invasive Strategy / Christopher P. Cannon 263

12 Glycoprotein IIb/IIIa Receptor Blockade in Myocardial Infarction: Adjunctive Therapy to Percutaneous Coronary Interventions / Franz-Josef Neumann 275

13 Glycoprotein IIb/IIIa Receptor Blockade in Acute Myocardial Infarction: Adjunctive Therapy to Fibrinolysis / Sorin J. Brener 289

Part IV Practical Issues and Future Applications

14 Economics of Glycoprotein IIb/IIIa Inhibition / Daniel B. Mark 305

15 Platelet Monitoring and Interaction of Glycoprotein IIb/IIIa Antagonists with Other Antiplatelet Agents / Steven R. Steinhubl 321

16 Platelet Glycoprotein IIb/IIIa Antagonists: Their Interaction with Low-Molecular-Weight Heparins and Direct Thrombin Inhibitors / Amol S. Bapat, Naji Yazbek, Neal S. Kleiman 341

17 Oral Agents / L. Kristin Newby 365

18 Platelet Glycoprotein IIb/IIIa Inhibitors: Effects Beyond the Platelet / Dean J. Kereiakes, Pascal J. Goldschmidt-Clermont 383

19 Cerebrovascular Interventions / Leslie Cho, Jay S. Yadav 397

20 Cerebrovascular Aspects of Glycoprotein IIb/IIIa Receptor Inhibitors / Cathy A. Sila 409

21 Evolution of Drug Development in Evidence-Based Medicine: Summary and the Future / David E. Kandzari, David F. Kong, Robert M. Califf 425.

Notes:

Includes bibliographical references and index.

ISBN:

1588291855

OCLC:

51234833