The identities of membrane steroid receptors : ... and other proteins mediating nongenomic steroid action / edited by Cheryl S. Watson.

Format:

Book

Contributor:

Watson, Cheryl S., 1950-

Language:

English

Subjects (All):

Steroid hormones--Receptors.

Steroid hormones.

Nuclear receptors (Biochemistry).

Receptors, Steroid.

Receptors, Cytoplasmic and Nuclear.

Medical Subjects:

Receptors, Steroid.

Receptors, Cytoplasmic and Nuclear.

Physical Description:

xiv, 208 pages : illustrations ; 24 cm

Place of Publication:

Boston : Kluwer Academic Publishers, [2003]

Summary:

The nature of rapid (nongenomic) steroid signaling has recently been reprobed with new experimental tools. Cellular responses to steroids start with membrane-initiated signals, eventually culminating in major transcriptional commitment and overhaul of cellular components. While much is known about the execution of the ultimate decision, little is known about how reception and processing of the first steroid signal notifies the cell of impending change. Therefore, it is very important to establish the identity of the proteins initiating these cellular responses. The Identities of Membrane Steroid Receptors ... And Other Proteins Mediating Nongenomic Steroid Action juxtaposes identifications from different laboratories and presents several possibilities: nuclear steroid receptor-like forms in nonnuclear locations, other known membrane receptors or channels with additional steroid binding sites, enzymes, transporters, receptors for serum steroid-binding proteins, and unique, previously undescribed proteins. While written by and for experts, The Identities of Membrane Steroid Receptors ... And Other Proteins Mediating Nongenomic Steroid Action also offers a comprehensive introduction to an important and hitherto underappreciated facet of steroid action.

Contents:

"Nuclear" Receptorsin the Membrane

1. Membrane-Associated Estrogen Receptors and Breast Cancer / Diana C. Marquez, Richard J. Pietras 1

2. A Membrane Form of Estrogen Receptor-[alpha] Mediates Estrogenic, Nongenomic Effects / Cheryl S. Watson, Dragoslava Zivadinovic, Nataliya Bulayeva, Bridget Hawkins, Celeste H. Campbell, Bahiru Gametchu 11

3. An Expanded View of Estrogen Receptor Localization in Neurons / Teresa A. Milner, Stephen E. Alves, Shinji Hayashi, Bruce S. McEwen 21

4. Regulation of Endothelial No Synthase Activity by Estrogen Receptors in A Steroid Receptor Fast-Action Complex (SRFC) In Caveolae / Philip W. Shaul, Ken L. Chambliss, Chieko Mineo 27

5. Estrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells / Lei Li, M. Page Haynes, Jeffrey R. Bender 37

6. Membrane Glucocorticoid Receptors and Glucocorticoid Signal Transduction / Bahiru Gametchu, Cheryl S. Watson 47

7. Nuclear Vitamin D (VDR) and Estrogen (ER) Receptors in the Membrane of Muscle and Breast Cancer Cells / Daniela Capitati, Graciela Santillan, Ana Rossi, Paula Monje, Ricardo Boland 57

Nuclear Receptors Physically Interact with Signal Cascade Molecules

8. The Role of Adapter Proteins in Er[alpha] Membrane Association and Function / Robert X-D. Song, Rakesh Kumar 67

9. Interactions of Estrogen Receptors with Signal Cascade Molecules / Ferdinando Auricchio, Antimo Migliaccio, Gabriella Castoria, Marina Di Domenico 77

10. Human Progesterone Receptor Cross-Talk with Cytoplasmic Signaling Molecules Through Direct Sh3 Domain Interaction / Viroj Boonyaratanakornkit, Dean P. Edwards 85

11. The Classical Progesterone Receptor Mediates Xenopus Oocyte Maturation Through a Non-Genomic Mechanism / X. Johne Liu, J. V. Ruderman 93

12. Steroid Hormone Receptor Interactions with Pak6, a Member of the P21 Activated Kinase Family / Steven P. Balk, Suzanne R. Lee 103

13. Membrane Localization and Rapid Non-Transcriptional Action of the Androgen Receptor / Sigrun Mink, Liubov Shatkina, Andrea Nestl, Andrew C. B. Cato 111

14. The Discovery and Function of Mtais in Er[alpha] Cytoplasmic Sequestration / Rui-An Wang, Rakesh Kumar 119

Unique, Previously Undescribed Receptors

15. Novel, Membrane-Intrinsic Receptors for Progesterone and Aldosterone / Ralf Losel, Michael Christ, Christoph Eisen, Elisabeth Falkenstein, Martin Feuring, Christiane Meyer, Armin Schultz, Martin Wehling 125

16. Current Knowledge of the Nature and Identity of Progestin and Estrogen Membrane Receptors in Fish Gonads / Peter Thomas, Yong Zhu, Yefei Pang 131

17. Evidence Supporting a Role for Gpr30, An Orphan Member of the G-Protein-Coupled Receptor Superfamily, in Rapid Estrogen Signaling / Edward J. Filardo, Jeffrey A. Quinn, C. Thomas Graeber 139

18. A Novel Non-Genomic Action of Estradiol (E) and Testosterone (T): Regulators of Microtubule Polymerization / Victor D. Ramirez, Jingjing Liu Kipp 147

19. Evidence That a Membrane Corticosteroid Receptor is an Opioid-Like Receptor / Frank L. Moore 157

20. Progestins Have Actions Through Gaba[subscript A] Receptors / Cheryl A. Frye, Sandra M. Petralia 165

21. Characteristics of a Nonclassical Membrane Estrogen Receptor in the Endocrine Pancreas / Ana B. Ropero, Angel Nadal 169

Proteins with Identities or Similarities to Other Non-Receptor Proteins

22. Protein Kinase C Isoforms as Non-Genomic Receptors / Brian J. Harvey, Christina M. Doolan 177

Chimeras

23. Membrane Estrogen Receptors in Human Spermatozoa: An Example of a Non-Classic Steroid Receptor Located in the Membrane / Michaela Luconi, Gianni Forti, Elisabetta Baldi 187

Receptors for Serumbinding Proteins

24. Sex Hormone Binding Globulin and Steroid Signaling at the Cell Membrane / Scott M. Kahn, Daniel J. Hryb, Atif M. Nakhla, Nicholas A. Romas, William Rosner 193.

Notes:

Includes bibliographical references and index.

ISBN:

1402073445

OCLC:

50773377