Mucus hypersecretion in respiratory disease.

Format:

Book

Contributor:

Chadwick, Derek.

Goode, Jamie.

Novartis Foundation.

Series:

Novartis Foundation symposium ; 248.

Novartis Foundation symposium ; 248

Language:

English

Subjects (All):

Respiratory organs--Diseases.

Respiratory organs.

Mucus.

Respiratory Tract Diseases.

Medical Subjects:

Respiratory Tract Diseases.

Mucus.

Genre:

Conference papers and proceedings.

Physical Description:

ix, 292 pages : illustrations ; 24 cm.

Place of Publication:

Chichester : Wiley, 2002.

Summary:

A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanisms that underlie and maintain this hypersecretory phenotype is therefore crucial for the development of rational approaches to therapy. Despite a high and increasing prevalence and cost to healthcare services and society, mucus hypersecretion in chronic respiratory disease has received little attention until recently, probably because of the difficulties inherent in studying this pathology. Only in the last few years have some of the genes involved in mucus secretion been characterized. The recent availability of genomic sequence information and specific antibodies has led to an explosion of interest in this area making this publication particularly timely. This book draws together contributions from an international and interdisciplinary group of experts, whose work is focused on both basic and clinical aspects of the problem. Coverage includes epidemiology, airways infection and mucus hypersecretion, the genetics and regulation of mucus production, models of mucus hypersecretion, and the implications of new knowledge for the development of novel therapies.

Contents:

Epidemiological studies in mucus hypersecretion / Jorgen Vestbo 3

Post-secretory fate of host defence components in mucus / Matthias Salathe, Rosanna Forteza, Gregory E. Conner 20

Mechanisms of submucosal gland morphogenesis in the airway / Mohammed Filali, Xiaoming Liu, Ningli Cheng, Duane Abbott, Vladimir Leontiev, John F. Engelhardt 38

Mucin-producing elements and inflammatory cells / Peter Jeffery, Jie Zhu 51

Respiratory tract mucins: structure and expression patterns / Julia R. Davies, Annkatrin Herrmann, Wayne Russell, Naila Svitacheva Claes Wickstrom, Ingemar Carlstedt 76

Development and validation of a lectin-based assay for the quantitation of rat respiratory mucin / Alan Jackson, Phil Kemp, June Giddings, Rosemary Sugar 94

Regulation of mucin secretion from in vitro cellular models / C. William Davis 113

Oscillations of pH inside the secretory granule control the gain of Ca[superscript 2+] release for signal transduction in goblet cells exocytosis / Wei-chun Chin, Ivan Quesada, Thuc Nguyen, Pedro Verdugo 132

A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction / Yuhong Zhou, Michael Shapiro, Qu Dong, Jamila Louahed, Christine Weiss, ShanHong Wan, Qiming Chen, Carl Dragwa, Dawn Savio, Minxue Huang, Catherine Fuller, Yaniv Tomer, Nicholas C. Nicolaides, Michael McLane, Roy C. Levitt 150

Mechanisms by which Gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR) / Carol Basbaum, Daizong Li, Erin Gensch, Marianne Gallup, Hassan Lemjabbar 171

Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways / Jack R. Harkema, James G. Wagner 181

Cytokine regulation of mucus production in a model of allergic asthma / Lauren Cohn, Laurie Whittaker, Naiqian Niu, Robert J. Homer 201

The role of apoptotic regulators in metaplastic mucous cells / Yohannes Tesfaigzi 221

Current and future therapies for airway mucus hypersecretion / Peter J. Barnes 237

Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseases / Bernd Disse 254.

Notes:

Papers from a symposium held at the Novartis Foundation, London, 26-28 Feb. 2002.

Includes bibliographical references and indexes.

Editors: Derek J. Chadwick and Jamie A. Goode.

ISBN:

0470844787

OCLC:

52209091