Bacterial protein toxins / edited by Drusilla L. Burns ... [and others].

Format:

Book

Contributor:

Burns, Drusilla L.

Language:

English

Subjects (All):

Bacterial toxins.

Bacterial Toxins.

Bacterial Proteins.

Medical Subjects:

Bacterial Toxins.

Bacterial Proteins.

Physical Description:

xvi, 348 pages, x pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Washington, D.C. : ASM Press, [2003]

Summary:

Designed for newcomers to the field of toxins, this important volume is intended to show how these proteins work while providing an up-to-date review of the field. Bacterial Protein Toxins describes all aspects of the biology of toxins, including their synthesis and secretion from the bacterial cell, their travels to and into the target host cell, and their modes of attacking the host cell machinery. It illustrates how bacterial toxins, each of which has distinct individual properties, often share mechanisms of secretion, membrane transport, and enzymatic action.

Contents:

I. Genetics and Regulation 1

1 Two-Component Systems / Scott Stibitz 3

2 Regulation of Bacterial Toxin Synthesis by Iron / Shelley M. Payne 25

3 AraC Family Regulators and Transcriptional Control of Bacterial Virulence Determinants / Dara W. Frank, Meredith L. Hunt 39

4 Quorum Sensing / Everett C. Pesci, Barbara H. Iglewski 55

II. Toxin Biogenesis: Crossing Bacterial Membrane Barriers 67

Box 1 Type V Export Systems: Proteins That Export Themselves / Drusilla L. Burns

5 The Type I Export Mechanism / Vassilis Koronakis, Jeyanthy Eswaran, Colin Hughes 71

6 Toxins and Type II Secretion Systems / Maria E. Scott, Maria Sandkvist 81

7 Type III Secretion Systems / Gregory V. Plano, Kurt Schesser, Matthew L. Nilles 95

Box 2 Pathogenicity Islands / Jorg Hacker

8 Type IV Secretion Systems / Drusilla L. Burns 115

III. Toxin Delivery into Eukaryotic Cells 129

9 Receptors for Bacterial Toxins / Catharine B. Saelinger 131

Box 3 Domain Structures of Bacterial Toxins / Stephen H. Leppla

Box 4 Recombinant Immunotoxins / David J. FitzGerald, Robert J. Kreitman, Ira Pastan

10 Direct Penetration of Bacterial Toxins across the Plasma Membrane / Franca R. Zaretzky, Mary C. Gray, Erik L. Hewlett 149

11 Transport of Toxins across Intracellular Membranes / Kirsten Sandvig 157

12 Transcytosis of Bacterial Toxins across Mucosal Barriers / Bonny L. Dickinson, Wayne I. Lencer 173

Box 5 Lipid Rafts / Bonny L. Dickinson, Wayne I. Lencer

IV. Toxin Action 187

13 Membrane-Damaging Toxins: Pore Formation / F. Gisou van der Goot 189

Box 6 The Vacuolating Toxin VacA of Helicobacter pylori / F. Gisou van der Goot

14 Membrane-Damaging Toxins: Family of RTX Toxins / Camilla Oxhamre, Agneta Richter-Dahlfors 203

15 Bacterial Toxins that Covalently Modify Eukaryotic Proteins by ADP-Ribosylation / Joseph T. Barbieri, Drusilla L. Burns 215

Box 7 Discovery that the Active Sites of Pseudomonas aeruginosa Exotoxin A and the Heat-Labile Enterotoxin of Escherichia coli Are Superimposable / Wim Hol

16 Glucosylating and Deamidating Bacterial Protein Toxins / Klaus Aktories 229

17 Plant and Bacterial Toxins as RNA N-Glycosidases / Angela Melton-Celsa, Alison D. O'Brien 245

18 Cytolethal Distending Toxin / Lawrence A. Dreyfus 257

19 Proteases / Ornella Rossetto, Fiorella Tonello, Cesare Montecucco 271

Box 8 Landmarks in Tetanus and Botulinum Research / Ornella Rossetto, Fiorella Tonello, Cesare Montecucco

20 Bacterial Toxins that Modulate Rho GTPase Activity / James B. Bliska, Gloria I. Viboud 283

21 Staphylococcal and Streptococcal Superantigens / Patrick M. Schlievert 293

V. Bacterial Toxins: Friends and Foes 309

22 Toxins as Vaccines and Adjuvants / Mariagrazia Pizza, Vega Masignani, Rino Rappuoli 311

23 Nefarious Uses of Bacterial Toxins / Drusilla L. Burns, Joseph T. Barbieri 327.

Notes:

Includes bibliographical references and index.

ISBN:

1555812457

OCLC:

50782610