Chemokines in the lung / edited by Robert M. Strieter, Steven L. Kunkel, Theodore J. Standiford.

Format:

Book

Contributor:

Strieter, Robert M., 1952-

Kunkel, S. L. (Steven L.)

Standiford, Theodore J.

Series:

Lung biology in health and disease ; v. 172.

Lung biology in health and disease ; v. 172

Language:

English

Subjects (All):

Pneumonia--Pathophysiology.

Pneumonia.

Chemokines--Pathophysiology.

Chemokines.

Lung Diseases--immunology.

Chemokines--immunology.

Chemotaxis, Leukocyte.

Inflammation.

Leukocytes--immunology.

Physiology, Pathological.

Medical Subjects:

Lung Diseases--immunology.

Chemokines--immunology.

Chemotaxis, Leukocyte.

Inflammation.

Leukocytes--immunology.

Physical Description:

xviii, 399 pages : illustrations ; 24 cm.

Place of Publication:

New York : Marcel Dekker, Inc., [2003]

Summary:

This reference discusses the role of chemokines in mediating leukocyte trafficking, angiogenesis, tumor cell metastasis, host defense, trauma-induced lung injury, and the progression of AIDS in the lung -- emphasizing their importance in health and potential applications for treating illnesses. Studies cytokines as natural agents for modulating diseases that affect the lung. More than 30 contributors assess the roles of chemokines in asthmatic airway responses...viral infections in the exacerbation of asthma...COPD...pulmonary inflammation in infants and children...neutrophil trafficking in cystic fibrosis...and antimicrobial host defense in the lung, and reveal strategies for inhibiting chemokines in ARDS...future uses of chemokines in the treatment of lung disease or injury...the role of CCR8 in granulomatous inflammation...the role of CXC chemokines/chemokine receptors during acute lung allograft rejection and infection...chemokine involvement in the recruitment of leukocytes to tumors and organ-specific metastasis...and the role of chemokines in pleural disease.

Contents:

II. Nomenclature System for Chemokine Ligands and Receptors 4

III. Interspecies Chemokine Homology: Therapeutic Implications 5

IV. Genomic Evolution of the Chemokine Superfamily: Functional Significance 6

V. Chemokine Receptors: Role in Tumor Cell Migration 7

2. Chemokine Receptors: Signaling Mechanisms and Roles in Immunoregulation / Ji-Liang Gao, Philip M. Murphy 11

II. Chemokine Receptor Repertoire and Specificity for Leukocytes and Ligands 12

III. Chemokine Receptors Signal Primarily Through G[subscript i]-Linked Pathways 13

IV. Chemokine Receptor Roles in Immunoregulation 16

V. Cooperation of Chemokine Receptors In Vivo 25

3. Regulation of Chemokine Expression by STAT Proteins / Mark H. Kaplan 37

II. Stat1 38

III. Stat4 39

IV. Stat6 41

V. BCL-6 42

4. The Role of Chemokines in Lymphocyte Trafficking to Lymph Nodes of the Lung / Kevin C. Wilson, William W. Cruikshank, David M. Center 47

II. Chemotaxis 48

III. Movement of T Lymphocytes from the Blood into the Lymph Nodes 49

IV. Movement of T Lymphocytes Within the Secondary Lymphoid Tissues 51

V. Diseases of the Lung 52

VI. B Lymphocytes 55

VII. Dendritic Cells 56

5. Genetic Models to Study Chemokine Biology in the Lung / Sergio A. Lira, Galya Vassileva, Shu-Cheng Chen, Nicholas W. Lukacs, Stephen W. Chensue, Theodore J. Standiford, Borna Mehrad, Donald N. Cook 65

II. Chemokine Ligands 66

III. Chemokine Receptors 69

6. The Role of Chemokines in Asthmatic Airway Responses / Cory M. Hogaboam, Jane M. Schuh, Alison E. John, Nicholas W. Lukacs 81

II. Sources of Chemokines in the Asthmatic Lung 82

III. Chemokines and Eosinophil Recruitment and Activation 84

IV. T-Lymphocyte Accumulation and Asthma 84

V. Chemokines and T-Lymphocyte Responses 86

VI. Viral Infections, Chemokines, and Asthma Exacerbation 86

VII. Airway Remodeling, Chemokines, and Asthma 88

7. Chemokines in Chronic Obstructive Pulmonary Disease / Zarin Brown, Emma M. Campbell 99

II. Chemokines and Chemokine Receptors Superfamily: Current Status 100

III. Chronic Obstructive Pulmonary Disease 100

IV. Role of Chemokines in Animal Models of Lung Injury 105

V. Future Directions 108

8. Pulmonary Inflammation in Cystic Fibrosis: Mechanisms and Consequences / David W. H. Riches 113

II. Pathophysiology of Cystic Fibrosis 114

III. Pulmonary Inflammation in Cystic Fibrosis 120

IV. Mechanisms of Pulmonary Inflammation 124

V. Future Challenges 134

9. Chemokines in Infectious Diseases of the Lung / Theodore J. Standiford, Wan C. Tsai, Borna Mehrad 145

I. Lung Antimicrobial Host Defense: Overview 145

II. Chemokines as Mediators of Pulmonary Host Defense 146

III. Role of CXC Chemokines/Receptors in Lung Antimicrobial Host Defense 147

IV. Role of ELR[superscript -] CXC Chemokines/Receptors in Lung Antimicrobial Host Defense 155

V. Role of CC Chemokines/Receptors in Lung Antimicrobial Host Defense 156

10. Chemokines and HIV / Brian R. Lane, David M. Markovitz 171

II. RANTES/CCL5, MIP-1[alpha]/CCL3, and MIP-1[beta]/CCL4 Can Suppress HIV Replication 172

III. CD4 Is Necessary, But Not Sufficient, for HIV-1 Entry 173

IV. CXCR4 and CCR5 Are HIV Coreceptors 173

V. Clinical Studies Suggest the Involvement of RANTES, MIP-1[alpha], and MIP-1[beta] in HIV Pathogenesis 175

VI. Genetic Evidence for the Importance of Chemokines and Their Receptors in HIV-1 Pathogenesis 175

VII. Alternative HIV Coreceptors 176

VIII. Coreceptor Expression and Cellular Tropism 176

IX. HIV Induces Signals via Chemokine Receptors 177

X. RANTES and SDF-1[alpha] Can Stimulate HIV-1 Replication Under Certain Circumstances 178

XI. Other Chemokines Affect HIV-1 Pathogenesis 178

XII. HIV Infection and the Lung 179

11. Chemokines in Acute Lung Injury / Thomas R. Martin, Richard B. Goodman 189

II. Pathophysiology of ARDS 190

III. Chemokines and Lung Inflammation 192

IV. Measurement Issues 194

V. Chemokines in Clinical Studies of ARDS 195

VI. Strategies for Inhibiting Chemokines in ARDS 212

VII. Future Directions 213

12. Chemokines in Granulomatous Lung Inflammation / Stephen W. Chensue, Akihiro Matsukawa, Cory M. Hogaboam, Steven L. Kunkel 221

II. The Chemokine Supergene Families of Ligands and Receptors 223

III. Cytokines, Chemokines, and Granulomatous Inflammation 225

IV. Animal Models of Chronic Lung Disease 226

13. Chemokines in Pulmonary Fibrosis / Michael P. Keane, John A. Belperio, Robert M. Strieter 239

II. The CXC Chemokines 241

III. The CC Chemokines 248

14. Chemokines and Chemokine Receptors in the Pathogenesis of Lung Allograft Rejection / John A. Belperio, Michael P. Keane, David J. Ross, Robert M. Strieter 261

II. Rejection and Lung Transplantation 262

III. Chemokines and Chemokine Receptors 264

IV. Chemokines and Chemokine Receptors and Acute Lung Allograft Rejection 266

V. CXC Chemokines/Chemokine Receptors During Acute Lung Allograft Rejection 274

VI. Fractalkine/CX[subscript 3]CL1 and Its Interaction with CX[subscript 3]CR1 During Acute Lung Allograft Rejection 279

VII. The Role of Chemokines/Chemokine Receptors During Chronic (BOS) Lung Allograft Rejection 281

15. Chemokines in Lung Cancer / Robert M. Strieter, John A. Belperio, Roderick J. Phillips, Steven M. Dubinett, Michael P. Keane 297

II. Involvement of Chemokines in Cellular Transformation 298

III. Involvement of Chemokines in the Regulation of Angiogenesis in Tumors 299

IV. Evidence That Chemokines Are Involved in Tumor Cell Invasion 311

V. Evidence That Chemokines Are Involved in the Recruitment of Leukocytes to the Tumor 313

VI. Evidence That Chemokines Regulate the Pattern of Organ-Specific Metastasis 315

16. Chemokines in Pleural Disorders / Veena B. Antony, Nasreen Najmunnisa 325

II. Chemokines and Chemokine Receptors in Infectious Disease 326

III. Chemokines and Chemokine Receptors in Malignant Disease 330

IV. Chemokines and Pleurodesis 333

V. Chemokines and Asbestos-Induced Pleural Disease 333

VI. Other Functions of Chemokines 334.

Notes:

Includes bibliographical references and index.

ISBN:

082470858X

OCLC:

51172062