Calcium homeostasis and signaling in aging / volume editor, Mark P. Mattson.

Format:

Book

Contributor:

Mattson, Mark P.

Series:

Advances in cell aging and gerontology ; v. 10.

Advances in cell aging and gerontology ; v. 10

Language:

English

Subjects (All):

Calcium--Metabolism--Disorders--Age factors.

Calcium.

Calcium--Physiological effect.

Aging--Molecular aspects.

Aging.

Calcium--Pathophysiology.

Calcium channels.

Calcium Metabolism Disorders.

Aging--physiology.

Calcium Channels.

Physiology, Pathological.

Calcium--Metabolism--Disorders.

Medical Subjects:

Calcium Metabolism Disorders.

Aging--physiology.

Calcium Channels.

Physical Description:

viii, 202 pages : illustrations ; 25 cm.

Edition:

First edition.

Place of Publication:

Amsterdam ; New York : Elsevier, 2002.

Summary:

Calcium is the most versatile ion in biological systems, regulating processes as diverse as cell motility, gene expression, neurotransmitter release and energy metabolism. Accordingly, all cells contain a complex array of membrane calcium channels and pumps, calcium-binding proteins, and enzymatic targets of calcium. Perturbed cellular calcium homeostasis occurs in many different age-related diseases and, in many cases, is central to the pathogenic process. Many cellular signaling systems that regulate subcellular calcium levels, as well as downstream targets of calcium, are highly sensitive to processes of aging including oxidative and metabolic stress. Calcium Homeostasis and Signaling in Aging provides a comprehensive review of the role of calcium in aging and age-related disease. Background chapters describe evolutionary aspects of calcium signaling, mechanisms of calcium homeostasis and signaling, and neuroendocrine regulation of calcium metabolism. A review of general alterations in calcium homeostasis and signaling that occur during normal aging segues into detailed coverage of the involvement of altered calcium signaling in the aging of specific organ systems, and in age-related diseases. An emphasis is placed on major diseases including cardiovascular disease, neurodegenerative disorders, diabetes, osteoporosis and immune disorders. The chapters also describe how information on calcium and aging is leading to new ways of promoting successful aging, and preventing and treating specific diseases. Each chapter, written by a international leader, provides a timely and information-rich view of the topic. This book will be of broad interest to graduate students, postdoctoral scientists and senior investigators in academia and industry who study aging or specific age-related diseases. Experts on calcium signaling who may have interest in applying their knowledge to aging and disease will also find this book an invaluable resource.

Contents:

Chapter 1 Calcium and Evolutionary Aspects of Aging / Mark P. Mattson 1

Chapter 2 Calcium Homeostasis and Signaling in Aging / Takuo Fujita 13

Chapter 3 Cellular Calcium Dynamics / Katsutoshi Furukawa, Yue Wang, Sic L. Chan 27

Chapter 4 Impact of Aging on Calcium Channels and Pumps / Masayoshi Yamaguchi 47

Chapter 5 Calcium Homeostasis and Learning Deficits in Aging / John Disterhoft, Wendy W. Wu 67

Chapter 6 Calcium and the Pathogenesis of Neurodegenerative Disorders / Mark Mattson, Charles Gilman 91

Chapter 7 Altered T-Lymphocyte Calcium Signaling and Age-Related Disease / Georg F. Weber 127

Chapter 8 Calcium Dysregulation, Insulin Release and the Pathogenesis of Diabetes / Peter Bergsten 147

Chapter 9 Calcium Homeostasis and Skeletal Muscle Alterations in Aging / Osvaldo Delbono 167

Chapter 10 Genetic and Dietary Factors in Age-Related Bone Loss / Serge Ferrari 179.

Notes:

Includes bibliographical references.

ISBN:

0444511350

OCLC:

49649570