Molecular medical parasitology / edited by J. Joseph Marr, Timothy W. Nilsen, Richard W. Komuniecki.

Format:

Book

Contributor:

Marr, J. Joseph (James Joseph)

Nilsen, Timothy W.

Komuniecki, Richard.

Language:

English

Subjects (All):

Medical parasitology.

Molecular parasitology.

Parasitic Diseases--physiopathology.

Host-Parasite Interactions--physiology.

Medical Subjects:

Parasitic Diseases--physiopathology.

Host-Parasite Interactions--physiology.

Physical Description:

xii, 488 pages, 8 unnumbered pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

Amsterdam ; Boston : Academic Press, [2003]

Summary:

A valuable, new source, Molecular Medical Parasitology is the only text of its kind -- one that applies broad concepts and current scientific advances from both molecular biology and biochemistry to the study of parasitic organisms. An internationally renowned team of scientists and physicians places parasites in their broad biological contexts while still emphasizing the specifics that differentiate these organisms. Not only will researchers and faculty in parasitology find this an indispensable guide, physicians will benefit from the thorough coverage molecular biology and biochemistry's current influences on treatment and management of parasitic diseases. Key Features* Features the most up-to-date scientific methods behind the medical management of parasitic diseases* Applies the most current synthesis of molecular biology and biochemistry to parasitic organisms* Contains many informative figures and clear illustrations

Contents:

I. Molecular Biology 1

1. Parasite genomics / Mark Blaxter 3

2. RNA processing in parasitic organisms: trans-splicing and RNA editing / Jonatha M. Gott, Timothy W. Nilsen 29

3. Transcription / Arthur Gunzl 47

4. Post-transcriptional regulation / Christine Clayton 67

5. Antigenic variation in African trypanosomes and malaria / George A.M. Cross 89

6. Genetic and genomic approaches to the analysis of Leishmania virulence / Stephen M. Beverley 111

II. Biochemistry and Cell Biology: Protozoa 123

7. Energy metabolism

Part I Anaerobic protozoa / Miklos Muller 125

Part II Aerobic protists - trypanosomatidae / Fred R. Opperdoes, Paul A.M. Michels 140

Part III Energy metabolism in the Apicomplexa / Michael J. Crawford, Martin J. Fraunholz, David S. Roos 154

8. Amino acid and protein metabolism / Juan Jose Cazzulo 171

9. Purine and pyrimidine transport and metabolism / Nicola S. Carter, Nicolle Rager, Buddy Ullman 197

10. Trypanosomatid surface and secreted carbohydrates / Salvatore J. Turco 225

11. Intracellular signaling / Larry Ruben, John M. Kelly, Debopam Chakrabarti 241

12. Plastids, mitochondria, and hydrogenosomes / Geoffrey Ian McFadden 277

III. Biochemistry and Cell Biology: Helminths 295

13. Helminth surfaces: structural, molecular and functional properties / David P. Thompson, Timothy G. Geary 297

14. Carbohydrate and energy metabolism in parasitic helminths / Richard Komuniecki, Aloysius G.M. Tielens 339

15. Neurotransmitters / Richard J. Martin, Jennifer Purcell, Tim Day, Alan P. Robertson 359

IV. Medical Applications 395

16. Drug resistance in parasites / Marc Ouellette, Steve A. Ward 397

17. Medical implications of molecular parasitology / Richard D. Pearson, Erik L. Hewlett, William A. Petri, Jr. 433.

Notes:

Includes bibliographical references and index.

ISBN:

0124733468

OCLC:

51895068