Neuroinflammation : mechanisms and management / edited by Paul L. Wood.

Format:

Book

Contributor:

Wood, Paul L.

Series:

Contemporary neuroscience

Language:

English

Subjects (All):

Nervous system--Degeneration--Immunological aspects.

Nervous system.

Inflammation.

Neuritis.

Inflammation--Mediators.

Nervous system--Pathophysiology.

Neurodegenerative Diseases--immunology.

Anti-Inflammatory Agents--pharmacology.

Inflammation--immunology.

Nerve Degeneration--immunology.

Neurodegenerative Diseases--drug therapy.

Nervous system--Degeneration.

Medical Subjects:

Neurodegenerative Diseases--immunology.

Anti-Inflammatory Agents--pharmacology.

Inflammation--immunology.

Nerve Degeneration--immunology.

Neurodegenerative Diseases--drug therapy.

Physical Description:

xi, 419 pages : illustrations ; 27 cm.

Edition:

Second edition.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

The field of neuroinflammation is evolving rapidly and now yielding many new potential therapeutics for clinical trials. In this thoroughly updated and revised edition of his much praised book, Neuroinflammation: Mechanisms and Management, Paul L. Wood and a panel of leading researchers capture all these new developments in a masterful synthesis of what is known today about the inflammatory mediators and the cells involved in neurodegenerative diseases. This second edition contains extensive updates on the mediators produced by microglia and their role in neuroinflammatory-induced neuronal lysis. There is also increased coverage of the animal models used in the study of neuroinflammatory mechanisms, of the new imaging methods that allow the noninvasive evaluation of microglial activation in human neurodegernerative disorders, and of the role of neuroinflammation in amyloid-dependent neuronal lysis. Up-to-date and insightful, Neuroinflammation: Mechanisms and Management, Second Edition, summarizes all the recent discoveries now playing a key role in both developing molecular targets and designing a new generation of drugs for acute and chronic neurodegenerative disorders alike.

Contents:

I. Neuroinflammatory Mechanisms

1 Microglia: Roles of Microglia in Chronic Neurodegenerative Diseases / Paul L. Wood 3

2 Apoptosis vs Nonapoptotic Mechanisms in Neurodegeneration / Kurt A. Jellinger 29

3 Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration / Christopher C. J. Miller, Steven Ackerley, Janet Brownlees, Andrew J. Grierson, Paul Thornhill 89

4 Roles of Chemokines and Their Receptors in Neuroinflammation / Andrzej R. Glabinski, Richard M. Ransohoff 99

5 Neurotoxic Mechanisms of Nitric Oxide / Kathleen M. K. Boje 117

6 Chronic Intracerebral LPS as a Model of Neuroinflammation / Gary L. Wenk, Beatrice Hauss-Wegrzyniak 137

7 Peroxisome Proliferator-Activated Receptor Gamma Agonists: Potential Therapeutic Agents for Neuroinflammation / Gary E. Landreth, Sophia Sundararajan, Michael T. Heneka 151

8 Neuroinflammation-Mediated Neurotoxin Production in Neurodegenerative Diseases: Potential of Nitrones as Therapeutics / Robert A. Floyd, Kenneth Hensley 171

II. Stroke and TBI

9 Inflammation and Potential Anti-Inflammatory Approaches in Stroke / Jari Koistinaho, Juha Yrjanheikki 189

10 Neuroinflammation as an Important Pathogenic Mechanism in Spinal Cord Injury / Yuji Taoka, Kenji Okajima 215

11 Type IV Collagenases and Blood-Brain Barrier Breakdown in Brain Ischemia / Yvan Gasche, Jean-Christophe Copin, Pak H. Chan 237

III. Alzheimer's Disease

12 Neuroinflammatory Environments Promote Amyloid-beta Deposition and Posttranslational Modification / Craig S. Atwood, Mark A. Smith, Ralph N. Martins, Rudolph E. Tanzi, Alex E. Roher, Ashley I. Bush, George Perry 249

13 Microglial Responses in Alzheimer's Disease: Recent Studies in Transgenic Mice and Alzheimer's Disease Brains / Douglas G. Walker, Lih-Fen Lue 267

14 The Amyloid Hypothesis of Cognitive Dysfunction / Dave Morgan, Marcia N. Gordon 283

15 The Cerebellum in AD: A Case for Arrested Neuroinflammation? / Paul L. Wood 295

16 The Neuroinflammatory Components of the Trimethyltin (TMT) Model of Hippocampal Neurodegeneration / G. Jean Harry, Christian Lefebvre d'Hellencourt 301

17 Inflammation and Cyclo-Oxygenase in Alzheimer's Disease: Experimental Approaches and Therapeutic Implications / Patrick Pompl, Tara Brennan, Lap Ho, Giulio Maria Pasinetti 331

IV. Multiple Sclerosis

18 Experimental Autoimmune Encephalomyelitis / Hans-Peter Hartung, Bernd C. Kieseier 345

19 Neuroimmunologic Mechanisms in the Etiology of Multiple Sclerosis / Claudia F. Lucchinetti, W. Bruck, Hans Lassmann 359

20 In Vivo Imaging of Neuroinflammation in Neurodegenerative Diseases / Annachiara Cagnin, Alexander Gerhard, Richard B. Banati 379

V. Parkinson's and Huntington's Diseases

21 Inflammatory Mechanisms in Parkinson's Disease / Joseph Rogers, Carl J. Kovelowski 391

22 Neuroinflammatory Components of the 3-Nitropropionic Acid Model of Striatal Neurodegeneration / Hideki Hida, Hiroko Baba, Hitoo Nishino 405.

Notes:

Includes bibliographical references and index.

ISBN:

1588290026

OCLC:

50859634