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Studies on notch and growth control / Prakash K. Rao.
LIBRA Diss. POPM2002.333
Available from offsite location
- Format:
- Book
- Manuscript
- Microformat
- Thesis/Dissertation
- Author/Creator:
- Rao, Prakash K.
- Language:
- English
- Subjects (All):
- Penn dissertations--Cell and molecular biology.
- Cell and molecular biology--Penn dissertations.
- Cell and Molecular Biology.
- Academic Dissertations as Topic.
- Medical Subjects:
- Cell and Molecular Biology.
- Academic Dissertations as Topic.
- Local Subjects:
- Penn dissertations--Cell and molecular biology.
- Cell and molecular biology--Penn dissertations.
- Physical Description:
- ix, 149 pages : illustrations ; 29 cm
- Production:
- 2002.
- Summary:
- The transmembrane protein Notch is at the core of a signaling pathway that determines a dazzling array of cell fates in vertebrates and invertebrates. It is perhaps, best known for its effects on inhibiting neurogenesis order to generate the ordered spacing of bristles in Drosophila melanogaster sensory organs. The acquisition of additional members of Notch within mammals has undoubtedly widened its use in higher organisms. A notable example is the lymphoid system. Notch is as a key regulator of T cell development and appropriate activation of this pathway is absolutely required for proper T-cell and B-cell development. Conversely, inappropriate activation of T cells has disastrous consequences as this can lead to T cell tumors.
- Mechanisms by which Notch causes tumors are unknown and is the focus of this thesis. We have discovered that Notch can confer a resistance to growth-inhibitory signals and propose that this may be a consequence of Notch's ability to transcriptionally activate a proto-oncogene c-Myc. We have also identified Schwann cells as a novel cell type that is susceptible to Notch-mediated transformation. These studies have allowed us to take an incremental step toward understanding the process by which Notch overrides normal growth control.
- Notes:
- Supervisor: Thomas Kadesch.
- Thesis (Ph.D. in Cell and Molecular Biology) -- University of Pennsylvania, 2002.
- Includes bibliographical references.
- Local Notes:
- University Microfilms order no.: 3073045.
- OCLC:
- 244972137
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