Oncogene-directed therapies / edited by Janusz Rak.

Format:

Book

Contributor:

Rak, Janusz.

Series:

Cancer drug discovery and development

Language:

English

Subjects (All):

Oncogenes.

Cancer--Molecular aspects.

Cancer.

Cancer--Gene therapy.

Biological response modifiers.

Neoplasms--therapy.

Medical Subjects:

Oncogenes.

Neoplasms--therapy.

Physical Description:

xiii, 486 pages : illustrations (some color) ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

In recent years an entirely new category of anticancer agents has entered the clinic. This class of drugs, the frontrunners of which are Herceptin and Gleevec, are no longer a product of the intuitive and largely empirical explorations that brought about traditional anticancer treatments like chemotherapy. Rather, these new agents have emerged directly from molecular analysis of various cancer-causing genes (oncogenes). In Oncogene-Directed Therapies, prominent investigators and clinicians, several of them pioneers in the field, summarize what is known about oncogenes and oncogenesis -- in a balanced blend of fundamental science, basic research, experimental therapeutics, and early clinical experience -- and describe how that knowledge can be used to treat the disease. The contributors explain how, why, and under what conditions certain proteins acquire the ability to transform eukaryotic cells, and detail the crucial biological consequences of this oncogenic transformation, particularly for cellular mitogenesis, survival, differentiation, migration, proteolysis, or angiogenic competence. Their articles thoroughly explicate the premises, principles, techniques, and approaches to oncogene targeting in various types of human cancer by using signal transduction inhibitors, immunological targeting methods, and antisense gene therapy. Also included is a review of the results of preclinical and clinical testing of some of today's most advanced therapeutic agents. Unique in perspective and comprehensive in its coverage, Oncogene-Directed Therapies not only integrates for all those engaged in -- or simply interested in the cutting-edge of -- "the war on cancer" the many remarkable recent achievements in our molecular understanding and treatment of these diseases, but also clarifies what directions future research might optimally take, as well as what significant accomplishments might lie ahead.

Contents:

Part I. Basic Concepts in Oncogene Research

1 Genetic Basis of Cancer Progression / Susan J. Done, Jeremy A. Squire 3

2 The Molecular Basis of Chromosomal Instability in Human Cancer Cells / Daniel P. Cahill 19

3 Signal Transduction Networks: Ras as a Paradigm / Frank McCormick 35

4 Oncogenic Receptor Tyrosine Kinases / Mark H. Kirschbaum, Mina D. Marmor, Yosef Yarden 47

5 Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis / Gretchen A. Murphy, Channing J. Der 77

6 The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis / Eric C. Holland 101

7 Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment / Amato J. Giaccia 113

Part II. The Functional Impact of Oncogene Expression on Cancer Cells

Therapeutic Implications

8 Deregulation of Cell Cycle Progression by Oncogenic Transformation / Marcelo L. Rodriguez-Puebla, Adrian M. Senderowicz, Claudio J. Conti 133

9 Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia / Kirill Rosen, Jorge Filmus 153

10 Oncogenes and Tumor Angiogenesis / Janusz Rak, Robert S. Kerbel 171

11 Oncogenes as Therapeutic Targets to Prevent Metastasis / Ann F. Chambers, Hemanth J. Varghese 219

12 The Impact of Oncogenes on Tumor Maintenance / Senji Shirasawa, Takehiko Sasazuki 229

13 Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems / Michaela Herzig, Gerhard Christofori 245

Part III. Oncogenes as Targets for Anticancer Therapy In Vivo

14 Targeting Oncogenes in Hematopoietic Malignancies / Michael E. O'Dwyer, Brian J. Druker 297

15 Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer / Edward H. Lin, James L. Abbruzzese 313

16 Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies / Gottfried E. Konecny, Jane Arboleda, Dennis J. Slamon, Mark Pegram 331

17 Farnesyltransferase Inhibitors as Anticancer Agents / Adrienne D. Cox 353

18 Targeting Oncogenic Signaling Pathways in Human Astrocytomas / Gelareh Zadeh, Abhijit Guha 363

19 Targeting Oncogenes in Pediatric Malignancies / Giannoula Klement, Robert S. Kerbel 383

20 Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells / Eric J. Bernhard, Anjali K. Gupta, Elizabeth Cohen-Jonathan, Ruth J. Muschel, Stephen M. Hahn, W. Gillies McKenna 409

21 Oncogenes as Targets for Cancer Vaccines / Samir N. Khleif, Joseph A. Lucci, III 433

22 Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria / Finbarr E. Cotter, Dean A. Fennell 453.

Notes:

Includes bibliographical references and index.

ISBN:

089603982X

OCLC:

50002208