Psychiatric genetics and genomics / edited by Peter McGuffin, Michael J. Owen, Irving I. Gottesman.

Format:

Book

Contributor:

McGuffin, P. (Peter)

Owen, M. J. (Michael J.)

Gottesman, Irving I.

Series:

Oxford medical publications

Language:

English

Subjects (All):

Behavior genetics.

Mental illness--Genetic aspects.

Mental illness.

Human molecular genetics.

Human chromosome abnormalities--Diagnosis--Moral and ethical aspects.

Human chromosome abnormalities.

Personality--Genetic aspects.

Personality.

Human chromosome abnormalities--Diagnosis.

Physical Description:

x, 472 pages : illustrations ; 25 cm.

Other Title:

Psychiatric genetics & genomics

Place of Publication:

Oxford ; New York : Oxford University Press, 2002.

Summary:

Genetics promises to provide one of the most powerful approaches to understanding the functional pathology of the human brain. This book presents a critical review of the evidence for a genetic contribution to common psychiatric conditions and the rarer single-gene disorders that may have psychiatric presentations. The first section of the book introduces the reader to molecular biology and the techniques of molecular genetics. The coverage then moves on to consider the genetics of normal and abnormal development, followed by a look at the genetics of abnormal behaviour in adults. This section includes, amongst others, consideration of personality disorders, schizophrenia, and the dementias. The final section considers the applications of the work and covers issues such as counselling and ethics, closing with a look to the future. The editors are internationally renowned figures in this field and they have invited a team of equally eminent chapter authors. This will be essential reading for psychiatrists and geneticists and will be of interest to neurologists, psychologists, and neuroscientists.

Contents:

1 Basic molecular genetics / Michael C. O'Donovan, Michael J. Owen 3

2 Quantitative genetics / Alastair Cardno, Peter McGuffin 31

3 Linkage and association / Pak Sham, Peter McGuffin 55

Part 2 The genetics of normal and abnormal development

4 Personality and cognitive abilities / Robert Plomin, Francesca Happe, Avshalom Caspi 77

5 Genetics of mental retardation / Anita Thapar, Jill Clayton-Smith 113

6 Reading and language disorders / Julie Williams 129

7 Childhood disorders / Anita Thapar, Jane Scourfield 147

Part 3 The genetics of abnormal behaviour in adult life

8 Personality disorders / Peter McGuffin, Terrie Moffitt, Anita Thapar 183

9 Genetics of affective disorders / Ian Jones, Lindsey Kent, Nick Craddock 211

10 Schizophrenia / Michael J. Owen, Michael C. O'Donovan, Irving I. Gottesman 247

11 Substance misuse / David Ball, David Collier 267

12 Anxiety and eating disorders / Thalia C. Eley, David Collier, Peter McGuffin 303

13 The dementias / Malcolm B. Liddell, Julie Williams, Michael J. Owen 341

Part 4 Applications and implications

14 Psychopharmacogenetics / Rob W. Kerwin, Maria J. Arranz 397

15 Genetic counselling / Jane Scourfield, Michael J. Owen 415

16 Ethical considerations in psychiatric genetics / Anne Farmer 425

17 The future and post-genomic psychiatry / Michael J. Owen, Peter McGuffin, Irving I. Gottesman 445

Appendix A brief guide to internet addresses for psychiatric genetics and genomics / Irving I. Gottesman 461.

Notes:

Includes bibliographical references and index.

ISBN:

0192631489

OCLC:

50271025