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American trypanosomiasis / edited by Kevin M. Tyler and Michael A. Miles.
Veterinary: Atwood Library (Campus) RC124.4 .A454 2003
Available
- Format:
- Book
- Series:
- World class parasites ; v. 7.
- World class parasites ; v. 7
- Language:
- English
- Subjects (All):
- Chagas' disease.
- Trypanosomiasis.
- Chagas Disease--prevention & control.
- Trypanosoma cruzi--genetics.
- Trypanosoma cruzi--pathogenicity.
- Medical Subjects:
- Trypanosomiasis.
- Chagas Disease--prevention & control.
- Trypanosoma cruzi--genetics.
- Trypanosoma cruzi--pathogenicity.
- Physical Description:
- 166 pages : illustrations ; 24 cm.
- Place of Publication:
- Boston : Kluwer Academic Publishers, [2003]
- Summary:
- American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T. cruzi is lifelong, and 10-30% of persons who harbor the parasite chronically develop cardiac and gastrointestinal problems associated with the parasitosis. Although major progress has been made in recent years in reducing vector-borne and transfusion-associated transmission of T. cruzi, the burden of disability and death in persons chronically infected with the organism continues to be enormous. Eight to ten million persons born in countries in which Chagas disease is endemic currently reside in the United States, and epidemiologic and census data suggest that 50,000-100,000 are chronically infected with T. cruzi. The presence of these infected persons poses a risk of transmission of the parasite in the USA through blood transfusion and organ transplantation and several such cases have now been documented.
- Contents:
- The life cycle of Trypanosoma cruzi / K. M. Tyler, C. L. Olson, D. M. Engman 1
- Novel cell biology of Trypanosoma cruzi / W. de Souza 13
- Trypanosoma cruzi surface proteins / A. C. C. Frasch 25
- Signaling in Trypanosoma cruzi / R. Docampo, S. N. J. Moreno 37
- Genetic diversity of Trypanosoma cruzi / O. Fernandes, B. Zingales 45
- Functional disection of Trypanosoma cruzi genome: new approaches in a new era / M. C. Taylor, J. M. Kelly 57
- Trypanosoma cruzi cell invasion mechanisms / N. Yoshida 69
- Recent developments in the pathology of Chagas disease with emphasis on the cardiovascular system / H. B. Tanowitz, S. M. Factor, J. Shirani, A. Ilercil, M. Wittner, J. Scharfstein, L. V. Kirchhoff 81
- The contribution of autoimmunity to Chagas heart disease / J. S. Leon, D. M. Engman 97
- Trypanosoma cruzi and Chagas disease: cause and effect / R. L. Tarleton 107
- Specific treatment for Trypanosoma cruzi infection (Chagas disease) / A. Rassi, A. O. Luquetti 117
- Rational approaches to specific chemotherapy of Chagas disease / J. A. Urbina 127
- The ecotopes and evolution of Trypanosoma cruzi and triatomine Bugs / M. A Miles, M. Yeo, M. Gaunt 137
- Paratransgenic strategies for the control of Chagas disease / E. M. Dotson, C. B. Beard 147
- Current public health concerns / L. V. Kirchhoff 157.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 1402073232
- OCLC:
- 50685296
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