Integrated biomaterials science / edited by Rolando Barbucci.

Format:

Book

Contributor:

Barbucci, Rolando.

Language:

English

Subjects (All):

Biomedical materials.

Medical instruments and apparatus.

Artificial organs.

Transplantation of organs, tissues, etc.

Biocompatible Materials.

Transplantation.

Medical Subjects:

Biocompatible Materials.

Transplantation.

Physical Description:

xxviii, 1037 pages : illustrations ; 24 cm

Place of Publication:

New York : Kluwer Academic/Plenum, [2002]

Summary:

Integrated Biomaterials Science provides an intriguing insight into the world of biomaterials. It explores the materials and technology which have brought advances in new biomaterials, highlighting the way in which modern biology and medicine are synergistically linked to other key scientific disciplines -- physics, chemistry, and engineering. In doing so, Integrated Biomaterials Science contains chapters on tissue engineering and gene therapy, standards and parameters of biomaterials, applications and interactions within the industrial world, as well as potential aspects of patent regulations. Integrated Biomaterials Science serves as a comprehensive guide to understanding this dynamic field, yet is designed so that chapters may be read and understood independently, depending on the needs of the audience. Integrated Biomaterials Science is attractive to a broad audience interested in a deeper understanding of this evolving field, and will serve as a key resource for researchers and students of biomaterials courses, providing all with an opportunity to probe further.

Contents:

1. Biological Materials / Yoshito Ikada

1.2. Fundamentals of Biological Materials 2

1.3. Medical Application of Biological Materials 14

2. Structure and Properties of Polymeric Materials / Walter Marconi, Antonella Piozzi

2.2. Polymers 27

2.3. Polymers in Medicine 36

2.4. Requirements and Evaluation of Polymeric Materials 43

3. Fundamentals of Polymeric Composite Materials / Claudio Migliaresi, Alessandro Pegoretti

3.2. Fiber Reinforcements 71

3.3. Matrix Resins 78

3.4. Fiber/Matrix Adhesion 84

3.5. Volume and Weight Fractions 87

3.6. Mechanics of Continuous-Fiber-Reinforced Composites 88

3.7. Mechanics of Discontinuous-Fiber-Reinforced Composites 99

3.8. Mechanics of Particulate Composites 106

3.9. Manufacture of Composites 108

4. Biodegradable Polymers / Luca Fambri, Claudio Migliaresi, Kernal Kesenci, Erhan Piskin

4.3. Mechanisms 121

4.4. Properties and Applications 126

4.5. Natural Polymers 129

4.6. Synthetic Polymers 145

4.7. Factors Affecting the Degradation of Polymeric Materials 165

5. Bioceramics and Biological Glasses / A. Krajewski, A. Ravaglioli

5.1. The Structure of Ceramics from Synthesis to Processing 189

5.2. Design and Duration of Ceramic Devices under Load 207

5.3. Ceramics for Surgical Implants 208

5.4. A Survey on the Adhesion of Ceramics to Bone Tissue 252

6. Metallic Materials / Alberto Cigada, Roberto Chiesa, Maria Rosa Pinasco, Kunihiro Hisatsune

6.1. The Crystalline Structure of Metallic Materials 255

6.2. Lattice Defects 256

6.3. Structure of Metallic Alloys 262

6.4. Phase Diagrams 263

6.5. Thermal Treatments 272

6.6. Strengthening of Metals 277

6.7. Working Technologies 280

6.8. Main Metallic Materials Used as Biomaterials 289

7. Degradation Processes on Metallic Surfaces / Emma Angelini, Angelo Caputo, Fabrizio Zucchi

7.2. The Biological Environment 297

7.3. Metallic Corrosion 298

7.4. Corrosion Forms 308

7.5. Corrosion Prevention 320

8. Characterization of Biomaterials / Donald Lyman

8.1. Requirements of Biomedical Characterization 325

8.2. Structure of Materials 327

8.3. The Nature of Surface Dynamics and Surface Analysis 328

8.4. Organization of Polymer Surfaces 330

9. Tissues / Luigi Ambrosio, Paolo A. Netti, Peter A. Revell

9.2. Soft Tissues 340

9.3. Hard Tissues 342

10. Soft Tissue / Luigi Ambrosio, Paolo A. Netti, Luigi Nicolais

10.1. Structure-Property Relationship of Soft Tissue 347

10.2. Skin 353

10.3. Tendons and Ligaments 357

11. The Eye / Domenico Lepore, Luigi Ambrosio, Roberto De Santis, Luigi Nicolais, Luigi Scullica

11.2. The Cornea 368

11.3. The Sclera 373

11.4. The Vitreous 375

12. Articular Cartilage / Paolo A. Netti, Luigi Ambrosio

12.2. Composition and Structure 382

12.3. Mechanical Properties 386

12.4. Electromechanical Transduction 394

12.5. Remodeling and Repair 396

13. The Mechanical and Material Properties of the Healthy and Degenerated Intervertebral Disc / Ron Alkalay

13.2. Anatomy 404

13.3. Material Properties of the Structures of the Disc 406

13.4. Mechanical Behavior of the Intervertebral Disc 411

13.5. The Effect of Degradation on the Mechanical Properties of the Disc 415

13.6. Intervertebral Disc Prostheses 416

14. Soft Tissue Replacement / Matteo Santin, Luigi Ambrosio, Andrew W. Lloyd, Stephen P. Denyer

14.2. Cardiovascular Devices 426

14.3. Intraocular Devices 436

14.4. Other Applications in Soft Tissue Replacement 444

15. Mechanics of Hard Tissues / Arturo N. Natali, Richard T. Hart

15.2. Experimental Methods and Results: Determination of Mechanical Properties and Structural Configuration 462

15.3. Mechanics of Bone 469

15.4. Bone Physiology 475

15.5. Functional Adaptation of Bone 476

15.6. Numerical Approach 482

16. Hip Joint Replacements / Giuseppe Guida, Dante Ronca

16.1 Introduction to Joint Replacements 491

16.2. History 492

16.3. Cemented Prostheses 498

16.4. The Noncemented Prostheses 505

16.5. Friction and Wear 517

17. Knee Joint Replacements / Dante Ronca, Giuseppe Guida

17.2. History 529

17.3. The Knee: Anatomical, Functional, and Structural Considerations 536

17.4. Polyethylene 537

17.5. Alignment 545

17.6. Fixation 546

17.7. Patellofemoral Joint 547

18. Biomaterial Applications: Elbow Prosthesis / Luigi Celli

18.2. The Prosthetic Design 556

18.3. Cases in which the Elbow Prosthesis Is Advisable 558

19. Biomaterial Applications: Shoulder Prosthesis / Luigi Celli

19.2. The Prosthetic Design 562

19.3. The Prosthetic Implantation 563

19.4. Conforming Design of the Articular Surfaces 564

19.5. Articular and Periarticular Resistances 566

19.6. The Active Role of Periarticular Muscles 566

20. Acrylic Bone Cements / Maria-Pau Ginebra, Francisco-Javier Gil, Josep-Anton Planell

20.2. Chemistry of Acrylic Bone Cements 570

20.3. Mechanical Properties 574

20.4. Factors Affecting the Microstructure and the Microstructure-Mechanical Properties Relationship 578

20.5. Biological Properties 582

20.6. Modification of Acrylic Bone Cements 582

21. Mechanical Properties of Tooth Structures / Roberto De Santis, Luigi Ambrosio, Luigi Nicolais

21.2. Mechanical Properties 592

22. Dental Materials and Implants / Maria Rosa Pinasco, Arturo Natali, Patrizia Loria, Marc Bolla, Franck J. Hagege

22.2. Stomatognatic Apparatus: Some Considerations 602

22.3. Dental Materials for Hard and Plastic Restorative Treatment 609

22.4. Materials for Complex Reconstructions 621

22.5. Prosthetic Therapy Materials 622

22.6. Dental Implant Materials: A Few Considerations 629

22.7. Biomaterials for Surgical Reconstitution 631

22.8. Dental Implants and Biomechanics 639

23. Materials/Biological Environment Interactions / Orsolina Petillo, Alfonso Barbarisi, Sabrina Margarucci, Alfredo De Rosa, Gianfranco Peluso

23.2. Cell-Extracellular Matrix Interactions 656

23.3. Growth Factors-Extracellular Matrix Interactions 658

23.4. Extracellular/Biomaterial Interaction 659

23.5. Future Perspectives 665

24. Protein Adsorption and Cellular/Tissue Interactions / Agnese Magnani, Gianfranco Peluso, Sabrina Margarucci, Krishnan K. Chittur

24.2. Protein Adsorption 670

24.3. Cells/Tissue Interactions 678

25. Inflammatory Response to Polymeric Materials / Denis Labarre, Marie-Paule Carreno

25.2. Polymeric Materials in Contact with Living Tissues 692

25.3. Characteristics of the Materials Involved in the Inflammatory Response 696

25.4. Assessing the Inflammatory Response to Materials 705

Appendix Abbreviations Used in this Chapter 723

26. Inflammatory Response to Metals and Ceramics / Arturo Pizzoferrato, Elisabetta Cenni, Gabriela Ciapetti, Donatella Granchi, Lucia Savarino, Susanna Stea

26.2. Materials Degradation and Inflammation 735

26.3. Acute Inflammatory Response 741

26.4. Chronic Inflammation 760

26.5. Toxicity of Biomaterials and Inflammation 767

26.6. Specific Immune Response 770

27. Biocompatibility and Biological Tests / Antonietta M. Gatti, Jonathan C. Knowles

27.2. Biocompatibility Tests and Their Rules 795

27.3. Biological Tests 796

27.4. Biofunctionality Tests 810

28. Infection and Sterilization / Roberto Giardino, Nicolo Nicoli Aldini

28.1. Infection 815

28.2. Sterilization 822

29. Drug Delivery Systems / Francesco M.

Veronese, Paolo Caliceti

29.2. Controlled or Programmable Drug Release versus Slow or Sustained Release 834

29.3. Biodegradable and Nonbiodegradable Polymers 836

29.4. Polymers for Controlled Release Applications 837

29.5. Novel Drug Delivery System Preparations 849

29.6. Internally or Externally Controlled Drug Delivery Systems 853

29.7. Transdermal Therapeutic Delivery Systems 859

29.8. Mechanisms of Drug Release 864

29.9. Overviews of Problems Involving Long-Term Contact between Tissues and Drug Delivery Systems 870

30. Gene Delivery as a New Therapeutic Approach / Libero Vitiello, Francesco M. Veronese

30.2. Different Kinds of Therapeutic Nucleic Acids 876

30.3. Viral Vectors 877

30.4. Synthetic Vectors 877

30.5. Clinical Applications of Gene Transfer 881

31. Tissue Engineering / Giovanni Abatangelo, Paola Brun, Marco Radice, Roberta Cortiro, Marcus K. H. Auth

31.2. Cell Culture and In Vitro Tissue Development 888

31.3. Artificial Skin 900

31.4. Artificial Cartilage 907

31.5. Artificial Bone 916

31.6. Glandular Parenchyma: The Liver 925

32. Assist Devices / Gerardo Catapano

32.2. Biomaterials Used in Extracorporeal Blood Processing 949

32.3. Artificial Devices 950

32.4. Bioartificial Devices 976

33. Standards on Biomaterials / Maria Vittoria Primiceri, Sandro Paci

33.2. ISO Standards and Overview 989

33.3. European System 992

34. Biomaterials and Patents / Maria Vittoria Primiceri

34.2. Patentable Inventions 1009

34.3. Patentability of Biomaterials 1012.

Notes:

Includes bibliographical references and index.

ISBN:

0306466783

OCLC:

47965971