Immune and inflammatory responses in the nervous system / [edited by] Nancy Rothwell and Sarah Loddick.

Format:

Book

Contributor:

Rothwell, Nancy.

Loddick, Sarah.

Series:

Molecular and cellular neurobiology series

Language:

English

Subjects (All):

Nervous system--Immunology.

Nervous system.

Neuroimmunology.

Nervous System--immunology.

Nervous System Diseases--immunology.

Immunology.

Medical Subjects:

Nervous System--immunology.

Nervous System Diseases--immunology.

Physical Description:

xii, 177 pages : illustrations ; 25 cm.

Edition:

Second edition.

Other Title:

Immune responses in the nervous system.

Place of Publication:

Oxford ; New York : Oxford University Press, 2002.

Summary:

This new edition covers recent advances in understanding immunological and inflammatory responses in the nervous system, research driven by the potential to use knowledge of the molecules and mechanisms involved to intervene in, and arrest, neurodegenerative disease processes. Immune and Inflammatory Responses in the Nervous System addresses developmental aspects of immune/inflammatory responses in the CNS, basic aspects of glial function, as well as inflammatory mediators, their mechanisms of action and clinical importance. There is also coverage of the major diseases of the CNS, including stroke, brain injury, multiple sclerosis and Alzheimer's disease. Throughout, the focus is on the underlying basic neuroscience, clinical relevance and the potential for therapeutic interventions. This will be an invaluable aid to understanding and improving the diagnosis of neuroimmune diseases and determining therapeutic measures. The contributors are all leading experts in the field and the content will be of interest to neuroscientists, neurologists, neuropathologists, neurosurgeons and immunologists.

Contents:

1 Developmental influences on inflammation in the brain / Daniel C. Anthony, Sandra J. Campbell 1

2 Imaging inflammation in the brain / Richard B. Banati 14

3 Astrocytic networks and brain injury / A. Verkhratsky, O. T. Jones 24

4 Blood-brain barrier and perivascular cells / Barbro B. Johansson 36

5 CNS responses to peripheral insults / Jan Pieter Konsman, Giamal N. Luheshi 51

6 Inflammatory events in focal cerebral ischaemia / Gregory J. del Zoppo, John M. Hallenbeck 70

7 Cytokines and neurodegeneration / Sarah Loddick, Nancy Rothwell 90

8 Inflammatory responses to traumatic brain injury: an overview for the new millennium / Maria-Cristina Morganti-Kossmann, Mario Rancan, Philip F. Stahel, Thomas Kossmann 106

9 Inflammatory demyelination and axonopathy in the central nervous system / M. L. Cuzner, M. N. Woodroofe 127

10 CNS immune reactions in Alzheimer's disease: microglia mediated mechanisms of inflammation in the Alzheimer's disease brain and their relevance to new therapuetic strategies / Joseph Rogers, Carl J. Kovelowski, Ron Strohmeyer 145

11 Transplantation of neuronal and non-neuronal cells into the brain / Hakan Widner 157.

Notes:

Previous ed. published as: Immune responses in the nervous system / edited by Nancy Rothwell. Oxford : Bios Scientific, 1995.

Includes bibliographical references and index.

ISBN:

0198509804

OCLC:

50402792