Allogeneic stem cell transplantation : clinical research and practice / edited by Mary J. Laughlin and Hillard M. Lazarus.

Format:

Book

Contributor:

Laughlin, Mary J.

Lazarus, Hillard M.

Series:

Current clinical oncology (Totowa, N.J.)

Current clinical oncology

Language:

English

Subjects (All):

Blood--Diseases.

Blood.

Hematopoietic stem cells--Transplantation.

Hematopoietic stem cells.

Hematopoietic Stem Cell Transplantation.

Transplantation, Homologous--methods.

Medical Subjects:

Hematopoietic Stem Cell Transplantation.

Transplantation, Homologous--methods.

Physical Description:

x, 454 pages : illustrations ; 26 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

Allogeneic transplantation has dramatically grown in importance as a curative cellular therapy for patients with hematologic malignancies and selected solid tumors, marrow failure disorders, and inherited metabolic diseases. In Allogeneic Stem Cell Transplantation: Clinical Research and Practice, internationally recognized physicians and researchers review both the basics of allogeneic stem cell transplantation and recent advances in the field, particularly as they relate to antitumor effects and graft-vs-host disease. They also provide unique decision-tree analyses to guide clinicians in selecting and managing their allogeneic transplant patients. The innovations discussed cover a variety of areas, ranging from stem cell mobilization in normal donors, to indications for allogeneic transplantation other than hematologic malignancies, to the use of non-myeloablative conditioning regimens. The authors also explore new developments in the optimal selection of unrelated allogeneic grafts (e.g., matched unrelated donor, partially mismatched family member, or umbilical cord blood), the use allogeneic peripheral blood stem cell vs marrow-derived grafts for transplantation, and the kinetics of immune reconstitution after transplantation. Comprehensive and up-to-date, Allogeneic Stem Cell Transplantation: Clinical Research and Practice offers both clinicians and researchers concise advice on today's best clinical practice, as well as insightful analysis of the promising new lines of laboratory research that are leading to safer and more effective allogeneic transplant procedures.

Contents:

Part I. Historical Perspective

1 Hematopoietic Stem Cell Transplantation: A Historical Perspective / Frederick R. Appelbaum 3

Part II. Disease Indications: Allogeneic Transplantation

2 Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myelogenous Leukemia / Henry C. Fung, Stephen J. Forman 13

3 Allogeneic Stem Cell Transplantation for Adult Acute Lymphoblastic Leukemia / Partow Kebriaei, Wendy Stock 29

4 Chronic Myelogenous Leukemia / Edward Copelan 47

5 Allogeneic Stem Cell Transplantation for Breast Cancer / Abby B. Siegel, Linda T. Vahdat 57

6 Allogeneic Transplantation for the Treatment of Multiple Myeloma / Stefano Tarantolo, Philip J. Bierman 69

7 Non-Hodgkin's Lymphoma / Igor Espinoza-Delgado, Dan L. Longo 83

Part III. Allogeneic Graft Selection

8 Blood vs Marrow Allogeneic Stem Cell Transplantation / Daniel Anderson, Daniel Weisdorf 103

9 Haploidentical Stem Cell Transplantation / Hillard M. Lazarus, Jacob M. Rowe 117

10 Umbilical Cord Blood Transplantation / Juliet Barker, John E. Wagner 129

11 Mesenchymal Stem Cells in Allogeneic Transplantation / Omer N. Koc, Stanton L. Gerson 151

12 Cytokines in Allogeneic Stem Cell Mobilization / Ravi Vij, Randy Brown, John F. DiPersio 159

13 Nonmyeloablative Allogeneic Transplantation / David A. Rizzieri, Nelson J. Chao 169

Part IV. Supportive Care in Allogeneic Transplantation

14 Recent Developments in Epidemiology and Management of Invasive Fungal Infections / Andreas H. Groll, Thomas J. Walsh 191

15 Immune Recovery Following Allogeneic Blood Transplantation: Mechanisms of Immune Dysfunction / James E. Talmadge 215

16 Grading and Management of Graft-vs-Host Disease / Donna Przepiorka 237

17 Posttransplant EBV-Associated Disease / Thomas G. Gross, Brett J. Loechelt 261

Part V. Prevention and Management of Relapse After Allogeneic Transplantation

18 Allogeneic Antitumor Vaccine Strategies / Ginna G. Laport, Carl H. June 273

19 Donor Leukocyte Infusions / Robert H. Collins, Jr. 287

20 Second Hematopoietic Stem Cell Transplantation for the Treatment of Graft Failure, Graft Rejection, or Relapse / Steven N. Wolff 311

Part VI. Preclinical Studies in Allogeneic Transplantation

21 The Role of T Cell Depletion in Bone Marrow Transplantation / Yair Reisner, Massimo F. Martelli 327

22 Minimal Residual Disease in Allogeneic Recipients / Jerald P. Radich 343

23 Nonhuman Primate Models of Hematopoietic Stem Cell Transplantation / Steven M. Devine, Ronald Hoffman 355

24 In Vivo Models for the Study of Graft-vs-Host Disease and Graft-vs-Tumor Effects / Kai Sun, William J. Murphy, Lisbeth A. Welniak 373

25 Allogeneic Effector Cell Populations: Separating GVL from GVHD / Michael R. Verneris, Robert S. Negrin 387

26 Dendritic Cells: Immunobiology and Potential Use for Cancer Immunotherapy / David Avigan 411.

Notes:

Includes bibliographical references and index.

ISBN:

089603979X

OCLC:

50002692