Pharmacogenetics of psychotropic drugs / edited by Bernard Lerer.

Format:

Book

Contributor:

Lerer, Bernard.

Language:

English

Subjects (All):

Psychotropic drugs.

Pharmacogenetics.

Psychotropic Drugs.

Medical Subjects:

Pharmacogenetics.

Psychotropic Drugs.

Physical Description:

x, 446 pages : illustrations (some color) ; 26 cm

Place of Publication:

Cambridge, UK ; New York : Cambridge University Press, 2002.

Summary:

Pharmacogenetics and pharmacogenomics are areas of rapidly growing importance at the interface of molecular genetics and psychopharmacology, with implications for drug development and clinical practice. This book provides a conceptual framework for understanding and studying the pharmacogenetics of psychotropic drugs; it reviews advances in the field and describes the findings that have already emerged.

Coverage extends to antipsychotics, antidepressants, mood-stabilizing, cognitive-enhancing, and anxiolytic drugs. Chapters also examine the interface of pharmacogenetics with substance dependence and brain imaging, and consider the impact of pharmacogenetics on the biotechnology and pharmaceutical industries.

This book defines the young field of pharmacogenetics as it applies to psychotropic drugs and is, therefore, an essential reference for all clinicians and researchers working in this field.

Contents:

1 Genes and psychopharmacology: exploring the interface / Bernard Lerer 3

Part II Clinical background and research design

2 From pharmacogenetics to pharmacogenomics of psychotropic drug response / Anil K. Malhotra 21

3 Neuropsychopharmacology: the interface between genes and psychiatric nosology / Thomas A. Ban 36

4 Methodological issues in psychopharmacolgenetics / Sheldon H. Preskorn 57

5 Statistical approaches in psychopharmacogenetics / Fabio Macciardi 72

Part III Molecular background

6 The psychopharmacogenetic-neurodevelopmental interface in serotonergic gene pathways / K. Peter Lesch, Jens Benninghoff, Angelika Schmitt 95

7 RNA processing regulation and interindividual variation / Colleen M. Niswender, Linda K. Hutchinson 127

Part IV Pharmacokinetics

8 Pharmacogenetics of psychotropic drug metabolism / Vural Ozdemir, Angela D.M. Kashuba, Vincenzo S. Basile, James L. Kennedy 157

9 Pharmacogenetics of chiral psychotropic drugs / Pierre Baumann, Chin B. Eap 181

Part V Specific psychotropic drugs and disorders

10 Clozapine response and genetic variation in neurotransmitter receptor targets / David A. Collier, Maria J. Arranz, Sarah Osborne, Katherine J. Aitchison, Janet Munro, Dalu Mancama, Robert W. Kerwin 217

11 Genetic factors underlying drug-induced tardive dyskinesia / Ronnen H. Segman, Bernard Lerer 245

12 Functional gene-linked polymorphic regions in pharmacogenetics / Marco Catalano 267

13 Alternative phenotypes and the pharmacogenetics of mood and anxiety disorders / Emanuela Mundo, James L. Kennedy 283

14 Pharmacogenetics of anxiolytic drugs and the GABA-benzodiazepine receptor complex / Smita A. Pandit, Spilios V. Argyropoulos, Patrick G. Kehoe, David J. Nutt 300

15 Genetic factors and long-term prophylaxis in bipolar disorder / Martin Alda 320

16 Genetic influences on responsiveness to anticonvulsant drugs / Thomas N. Ferraro 333

17 Apolipoprotein E as a marker in the treatment of Alzheimer's disease / Keith Schappert, Pierre Sevigny, Judes Poirier 360

18 Genetic variation and drug dependence risk factors / Joel Gelernter, Henry Kranzler 372

Part VI Pharmacogenetics and brain imaging

19 Brain imaging and pharmacogenetics in Alzheimer's disease and schizophrenia / Steven G. Potkin, James L. Kennedy, Vincenzo S. Basile 391

Part VII Industry perspectives

20 Pharmacogenetics in psychotropic drug discovery and development / William Z. Potter, AnnCatherine Van Lone, Larry Altstiel 401

21 High-throughput single nucleotide polymorphism genotyping / Anne Shalom, Ariel Darvasi 420.

Notes:

Includes bibliographical references and index.

ISBN:

0521806178

OCLC:

48055510

Online:

Publisher description