Stem cells : a cellular fountain of youth / edited by Mark P. Mattson and Gary van Zant.

Format:

Book

Contributor:

Mattson, Mark P.

Van Zant, Gary

Alumni and Friends Memorial Book Fund.

Series:

Advances in cell aging and gerontology ; v. 9.

Advances in cell aging and gerontology ; v. 9

Language:

English

Subjects (All):

Cells--Aging.

Cells.

Stem cells.

Stem Cells.

Aging.

Medical Subjects:

Stem Cells.

Aging.

Physical Description:

viii, 225 pages : illustrations (some color) ; 25 cm.

Edition:

First edition.

Place of Publication:

Amsterdam ; Boston : Elsevier, 2002.

Summary:

The developmental capabilities and therapeutic potential of stem cells are being revealed in studies of cellular signaling mechanisms that regulate their proliferation, differentiation and survival. "Stem Cells: A Cellular Fountain of Youth" reviews the current state of understanding of the molecular mechanisms that regulate embryonic and adult stem cells with an emphasis on how aging and age-related disease impact on these mechanisms. Leading authorities detail the properties and therapeutic potential of embryonic stem cells, and stem cell precursors of blood, nervous and muscle and bone cells. Recent advances in deciphering the environmental signals and intrinsic signal transduction pathways that regulate embryonic stem cells are described, and the potential therapeutic uses of these totipotent cells is considered. Analyses of hematopoietic stem cells during aging suggest an important genetic component to the control of their self-renewing capability which may contribute to determination of lifespan. The contribution of lymphocyte depletion to impaired immune function during aging is considered, as is the potential of hematopoietic cells to form other types of cells including neurons. Several chapters cover the remarkable and rapidly advancing field of neural stem cells. The adult brain contains populations of stem cells capable of forming new neurons and glial cells; the signals that regulate these neural stem cells and the involvement of neurogenesis in normal brain function is described. Because of their potential to replace lost or damaged neurons, there has been intense interest in determining the therapeutic potential of stem cells for the treatment of patients with Parkinson's and Alzheimer's diseases, stroke and traumatic brain and spinal cord injuries. Heart and skeletal muscle contain stem cells and the impact of aging and disease on these stem cell populations and the potential of stem cell therapy to recover function of these organs is reviewed. A final example of the fascinating world of stem cells is a review of the roles of stem cells in bone formation and remodeling. Collectively, this book provides a comprehensive, yet concise, view of stem cell molecular biology in the context of aging and age-related disease. This book will be a valuable reference for graduate students and senior scientists interested in the fascinating world of stem cells and their potential use in the clinic.

Contents:

Chapter 1 Signaling Pathways Influencing Embryonic Stem Cell Self-renewal and Differentiation / Thomas. E. Smithgall 1

Chapter 2 Hematopoietic Stem Cells and Aging / Gary Van Zant, Erin L. Manning, Hartmut Geiger 19

Chapter 3 Haematopoietic Stem Cells and the Thymus in Aging / Amiela Globerson 43

Chapter 4 Plasticity of Adult Bone Marrow Stem Cells / Karen J. Chandross, Eva Mezey 73

Chapter 5 Aging Neural Stem Cells / Jingli Cai, Mahendra Rao 97

Chapter 6 Stem Cells and Neurodegenerative Disorders / Mark P. Mattson, Norman Haughey, Aiwu Cheng, Mahendra S. Rao 117

Chapter 7 Myocardial Aging and Embryonic Stem Cell Biology / Kenneth R. Boheler, Anna M. Wobus 141

Chapter 8 Adult Skeletal Muscle Growth and Regeneration: The Development and Differentiation of Myogenic Stem Cells / Patrick Seale, Michael A. Rudnicki 177

Chapter 9 Stem Cells In Bone Formation and Remodeling / Robert L. Jilka, A. Michael Parfitt 201.

Notes:

Includes bibliographical references.

Local Notes:

Acquired for the Penn Libraries with assistance from the Alumni and Friends Memorial Book Fund.

ISBN:

0444507310

OCLC:

50285285