Myasthenia gravis and related disorders / edited by Henry J. Kaminski.

Format:

Book

Contributor:

Kaminski, Henry J.

Series:

Current clinical neurology

Language:

English

Subjects (All):

Myasthenia gravis.

Neuromuscular diseases.

Myoneural junction.

Myasthenia Gravis--physiopathology.

Myasthenia Gravis--therapy.

Neuromuscular Junction Diseases--diagnosis.

Neuromuscular Junction Diseases--physiopathology.

Medical Subjects:

Myasthenia Gravis--physiopathology.

Myasthenia Gravis--therapy.

Neuromuscular Junction Diseases--diagnosis.

Neuromuscular Junction Diseases--physiopathology.

Physical Description:

x, 396 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2003]

Summary:

Myasthenia gravis, the best understood autoimmune disorder, serves as a model not only for study of the pathogenesis and treatment of all autoimmune diseases, but also for understanding synaptic function. In Myasthenia Gravis and Related Disorders, Henry J. Kaminski, MD, and an international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromyotonia and Lambert-Eaton syndrome. For the clinician, the book offers a rich portrait of the wide range of signs and symptoms that make these diseases difficult to diagnose. Replete with beautiful illustrations that carry the discussion well beyond the typical textbook, the authors review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatment strategies now emerging. For the basic scientist, the text illuminates neuromuscular structure and function (the site of autoimmune pathology) and describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis).

Authoritative and insightful, Myasthenia Gravis and Related Disorders follows this difficult illness from molecule to patient adaptation to illness, translating sophisticated evidence-based medicine into approaches directly useful in the doctor's office for effective patient diagnosis and treatment.

Contents:

1 Neuromuscular Junction Physiology and Pathophysiology / Robert L. Ruff 1

2 Acetylcholine Receptor Structure / Jon M. Lindstrom 15

3 Immunopathogenesis of Myasthenia Gravis / Bianca M. Conti-Fine, Brenda Diethelm-Okita, Norma Ostlie, Wei Wang, Monica Milani 53

4 Clinical Presentation and Epidemiology of Myasthenia Gravis / Jan B.M. Kuks, Hans J.G.H Oosterhuis 93

5 Ocular Myasthenia / Robert B. Daroff 115

6 Thymoma-Associated Myasthenia Gravis / Alexander Marx, Philipp Stroebel 129

7 Electrodiagnosis of Neuromuscular Junction Disorders / Bashar Katirji 149

8 Specific Antibodies in the Diagnosis and Management of Autoimmune Disorders of Neuromuscular Transmission and Related Diseases / Mark A. Agius, David P. Richman, Angela Vincent 177

9 Treatment of Myasthenia Gravis / Henry J. Kaminski 197

10 Neurocritical Care of Myasthenia Gravis Crisis / Jose Americo M. Fernandes Filho, Jose I. Suarez 223

11 Thymectomy / Alfred Jaretzki III 235

12 Lambert-Eaton Syndrome / C. Michel Harper, Vanda A. Lennon 269

13 Acquired Neuromyotonia / Ian Hart, Angela Vincent 293

14 Congenital Myasthenic Syndromes / Suraj A. Muley, Christopher M. Gomez 309

15 Toxic Neuromuscular Transmission Disorders / James F. Howard, Jr. 327

16 Psychological and Social Consequences of Myasthenia Gravis / Robert H. Paul, James M. Gilchrist 355

Appendix Myasthenia Gravis Foundation of America Recommendations for Clinical Research Standards 373.

Notes:

Includes bibliographical references and index.

ISBN:

1588290581

OCLC:

49322430