Pharmaceutical perspectives of nucleic acid-based therapeutics / edited by Ram I. Mahato and Sung Wan Kim.

Format:

Book

Contributor:

Kim, Sung Wan.

Language:

English

Subjects (All):

Gene therapy.

Nucleic acids--Therapeutic use.

Nucleic acids.

Genetic Therapy.

Nucleic Acids--therapeutic use.

Medical Subjects:

Genetic Therapy.

Nucleic Acids--therapeutic use.

Physical Description:

xxix, 521 pages, 8 unnumbered pages of plates : illustrations (some color) ; 25 cm

Place of Publication:

London ; New York : Taylor & Francis, 2002.

Contents:

1 Basic components of gene expression plasmids / Jun-Ichi Miyazaki 1

2 Inducible gene expression strategies in gene therapy / Eugene W. Gerner, Natalia A. Ignatenko, Kimberly E. Fultz 15

3 Modulation of gene expression by antisense oligonucleotides / Ruiwen Zhang, Hui Wang 33

4 Ribozymes as therapeutic agents and genetic tools / Alessandra Poggi, Alessandro Michienzi, John J. Rossi 54

5 Peptide nucleic acids (PNA) binding-mediated target gene transcription / Gan Wang, Xiaoxin Xu 73

6 Aptamers for controlling gene expression / Jean-Jacques Toulme, Eric Dausse, Fanny Santamaria, Bernard Rayner 89

7 Enzymes acting on DNA breaks and its relevance in nucleic acid-based therapy / Masahiko S. Satoh, Tetsu M.C. Yung 121

8 Compaction and condensation of DNA / Kenichi Yoshikawa, Yuko Yoshikawa 136

9 Structure, dispersion stability and dynamics of DNA and polycation complexes / Alexander V. Kabanov, Tatiana K. Bronich 164

10 Structure and structure-activity correlations of cationic lipid/DNA complexes: supramolecular assembly and gene delivery / Cyrus R. Safinya, Alison J. Lin, Nelle L. Slack, Ilya Koltover 190

11 Cellular uptake, metabolic stability and nuclear translocation of nucleic acids / Delphine Lechardeur, Gergely L. Lukacs 210

12 Nucleocytoplasmic trafficking / David A. Dean 229

13 Optimizing RNA export for transgene expression / Ileana Popa, Thomas J. Hope 261

14 Naked plasmid DNA delivery of a therapeutic protein / Holly M. Horton, Suezanne E. Parker 285

15 Cationic lipid-based gene delivery / Gerardo Byk 302

16 Peptide-based gene delivery systems / Patrick Midoux, Chantal Pichon 334

17 Cationic and non-condensing polymer-based gene delivery / Heidi L. Holtorf, Antonios G. Mikos 367

18 Device-mediated gene delivery / Alexander L. Rakhmilevich, Georg Widera 388

19 Basic pharmacokinetics of oligonucleotides and genes / Makiya Nishikawa, Yoshinobu Takakura, Fumiyoshi Yamashita, Mitsuru Hashida 409

20 Interstitial transport of macromolecules: implication for nucleic acid delivery in solid tumors / Sarah McGuire, David Zaharoff, Fan Yuan 434

21 Hepatic delivery of nucleic acids using hydrodynamics-based procedure / Dexi Liu, Guisheng Zhang 455

22 Role of CpG motifs in immunostimulation and gene expression / Paul J. Payette, Heather L. Davis, Arthur M. Krieg 469

23 Local cardiovascular gene therapy / Mikko P. Turunen, Mikko O. Hiltunen, Seppo Yla-Herttuala 487

24 Gene therapy for cardiovascular disease / David A. Bull, Stephen H. Bailey, Lei Yu, David G. Affleck, Sung Wan Kim 499

25 Gene therapy for the prevention of autoimmune diabetes / Kyung Soo Ko, Minhyung Lee, Sung Wan Kim 508.

Notes:

Includes bibliographical references and index.

ISBN:

041528385X

OCLC:

49395129